Stereological assessment of age-related changes in lipid droplet surface area and vascular volume in rat interscapular brown adipose tissue

1988 ◽  
Vol 220 (4) ◽  
pp. 357-363 ◽  
Author(s):  
Joseph O. Nnodim
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Surface Area ◽  
Lipid Droplet ◽  
Droplet Surface ◽  
Interscapular Brown Adipose Tissue ◽  
Vascular Volume ◽  
Age Related ◽  
Brown Adipose ◽  
Age Related Changes

Impact of UCP1 and β3AR gene polymorphisms on age-related changes in brown adipose tissue and adiposity in humans

2012 ◽  
Vol 37 (7) ◽  
pp. 993-998 ◽  
Author(s):  
T Yoneshiro ◽  
T Ogawa ◽  
N Okamoto ◽  
M Matsushita ◽  
S Aita ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Gene Polymorphisms ◽  
Age Related ◽  
Brown Adipose ◽  
Age Related Changes

scholarly journals Glucose transporter expression and glucose utilization in skeletal muscle and brown adipose tissue during starvation and re-feeding

1992 ◽  
Vol 282 (1) ◽  
pp. 231-235 ◽  
Author(s):  
D M Smith ◽  
S R Bloom ◽  
M C Sugden ◽  
M J Holness
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Tibialis Anterior ◽  
Glucose Transporter ◽  
Glucose Utilization ◽  
Interscapular Brown Adipose Tissue ◽  
Glut 4 ◽  
Mrna Concentration ◽  
Brown Adipose ◽  
Transporter Expression

Starvation (48 h) decreased the concentration of mRNA of the insulin-responsive glucose transporter isoform (GLUT 4) in interscapular brown adipose tissue (IBAT) (56%) and tibialis anterior (10%). Despite dramatic [7-fold (tibialis anterior) and 40-fold (IBAT)] increases in glucose utilization after 2 and 4 h of chow re-feeding, no significant changes in GLUT 4 mRNA concentration were observed in these tissues over this re-feeding period. The results exclude changes in GLUT 4 mRNA concentration in mediating the responses of glucose transport in these tissues to acute re-feeding after prolonged starvation.

scholarly journals Changes in β1- and β2-adrenergic receptor mRNA levels in brown adipose tissue and heart of hypothyroid rats

1991 ◽  
Vol 277 (3) ◽  
pp. 625-629 ◽  
Author(s):  
J P Revelli ◽  
R Pescini ◽  
P Muzzin ◽  
J Seydoux ◽  
M G Fitzgerald ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Adrenergic Receptor ◽  
State Level ◽  
Total Density ◽  
Mrna Levels ◽  
Interscapular Brown Adipose Tissue ◽  
Brown Adipose ◽  
Displacement Experiments ◽  
Beta 2

The aim of the present work was to study the effect of hypothyroidism on the expression of the beta-adrenergic receptor (beta-AR) in interscapular brown adipose tissue and heart. The total density of plasma membrane beta-AR per tissue is decreased by 44% in hypothyroid rat interscapular brown adipose tissue and by 55% in hypothyroid rat heart compared with euthyroid controls. The effects of hypothyroidism on the density of both beta 1- and beta 2-AR subtypes were also determined in competition displacement experiments. The densities of beta 1- and beta 2-AR per tissue are decreased by 50% and 48% respectively in interscapular brown adipose tissue and by 52% and 54% in the heart. Northern blot analysis of poly(A)+ RNA from hypothyroid rat interscapular brown adipose tissue demonstrated that the levels of beta 1- and beta 2-AR mRNA per tissue are decreased by 73% and 58% respectively, whereas in hypothyroid heart, only the beta 1-AR mRNA is decreased, by 43%. The effect of hypothyroidism on the beta 1-AR mRNA is significantly more marked in the interscapular brown adipose tissue than in the heart. These results indicate that beta-AR mRNA levels are differentially regulated in rat interscapular brown adipose tissue and heart, and suggest that the decrease in beta-AR number in interscapular brown adipose tissue and heart of hypothyroid animals may in part be explained by a decreased steady-state level of beta-AR mRNA.

scholarly journals Stimulatory, but not anxiogenic, doses of caffeine act centrally to activate interscapular brown adipose tissue thermogenesis in anesthetized male rats

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
L. Van Schaik ◽  
C. Kettle ◽  
R. Green ◽  
W. Sievers ◽  
M. W. Hale ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Basolateral Amygdala ◽  
Free Breathing ◽  
Male Rats ◽  
Central Administration ◽  
Hypothalamic Area ◽  
Interscapular Brown Adipose Tissue ◽  
Brown Adipose ◽  
Brown Adipose Tissue Thermogenesis

AbstractThe role of central orexin in the sympathetic control of interscapular brown adipose tissue (iBAT) thermogenesis has been established in rodents. Stimulatory doses of caffeine activate orexin positive neurons in the lateral hypothalamus, a region of the brain implicated in stimulating BAT thermogenesis. This study tests the hypothesis that central administration of caffeine is sufficient to activate BAT. Low doses of caffeine administered either systemically (intravenous [IV]; 10 mg/kg) and centrally (intracerebroventricular [ICV]; 5–10 μg) increases BAT thermogenesis, in anaesthetised (1.5 g/kg urethane, IV) free breathing male rats. Cardiovascular function was monitored via an indwelling intra-arterial cannula and exhibited no response to the caffeine. Core temperature did not significantly differ after administration of caffeine via either route of administration. Caffeine administered both IV and ICV increased neuronal activity, as measured by c-Fos-immunoreactivity within subregions of the hypothalamic area, previously implicated in regulating BAT thermogenesis. Significantly, there appears to be no neural anxiety response to the low dose of caffeine as indicated by no change in activity in the basolateral amygdala. Having measured the physiological correlate of thermogenesis (heat production) we have not measured indirect molecular correlates of BAT activation. Nevertheless, our results demonstrate that caffeine, at stimulatory doses, acting via the central nervous system can increase thermogenesis, without adverse cardio-dynamic impact.

Organization of sympathetic innervation of interscapular brown adipose tissue in the mouse

2021 ◽  
Author(s):  
Clara Huesing ◽  
Rui Zhang ◽  
Sanjeev Gummadi ◽  
Nathan Lee ◽  
Emily Qualls‐Creekmore ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Sympathetic Innervation ◽  
Interscapular Brown Adipose Tissue ◽  
Brown Adipose

scholarly journals Corrigendum: Cvijic G, Lakic I, Vujovic P, Jasnic N, Djurasevic S, Dronjak-Cucakovic S, Djordjevic J. Single and combined effects of acute and chronic non-thermal stressors on rat interscapular brown adipose tissue metabolic activity. Arch biol sci. 2013;65(3):919-27 DOI:10.2298/ABS1303919C

2015 ◽  
Vol 67 (4) ◽  
pp. 1431-1431
Author(s):  
E Editorial
Keyword(s):  
Biological Sciences ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Metabolic Activity ◽  
Combined Effects ◽  
Interscapular Brown Adipose Tissue ◽  
Brown Adipose ◽  
New Findings ◽  
Partial Overlap ◽  
Font Color

The Editor-in-Chief has been informed that the results in Fig. 2A in the article: Single and combined effects of acute and chronic non-thermal stressors on rat interscapular brown adipose tissue metabolic activity, published in the Archives of Biological Sciences in 2013, Vol. 65, Issue 3, partially overlap with the results in Fig. 2, published in the article: Lakic I, Drenca T, Djordjevic J, Vujovic P, Jasnic N, Djurasevic S, Dronjak-Cucakovic S, Cvijic G. Arch Biol Sci. 2011;63(3):589-96, DOI:10.2298/ABS1103589L. After inspection of these articles and illustrations, and after discussion with the corresponding author of both articles, it was revealed that this is a case of partial overlap, i.e. of the authors presenting new findings that contain a comparatively small amount of previously published information. By publishing this corrigendum the journal is providing appropriate cross-referencing to the earlier work. <br><br><font color="red"><b> Link to the corrected article <u><a href="http://dx.doi.org/10.2298/ABS1303919C">10.2298/ABS1303919C</a></b></u>

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