Monosodium glutamate induced lesions of the arcuate nucleus. I. Endocrine deficiency and ultrastructure of the median eminence

1976 ◽  
Vol 186 (2) ◽  
pp. 185-196 ◽  
Author(s):  
M. A. Holzwarth-Mcbride ◽  
E. M. Hurst ◽  
K. M. Knigge
Keyword(s):  
Median Eminence ◽  
Arcuate Nucleus ◽  
Monosodium Glutamate

Corticoliberin and somatoliberin activity in the pituitary stalk median eminence of rats after neonatal treatment with monosodium glutamate

1982 ◽  
Vol 93 (2) ◽  
pp. 239-245 ◽  
Author(s):  
Zsuzsanna Ács ◽  
F. A. Antoni ◽  
G. B. Makara
Keyword(s):  
Median Eminence ◽  
Arcuate Nucleus ◽  
Monosodium Glutamate ◽  
Plasma Corticosterone ◽  
Pituitary Stalk ◽  
Corticosterone Concentration ◽  
Medial Basal Hypothalamus ◽  
Neonatal Treatment ◽  
Neurotoxic Lesions ◽  
Plasma Gh

Neurotoxic lesions of the arcuate nucleus by neonatal treatment with monosodium glutamate (MSG) resulted in a decrease of plasma GH levels without affecting plasma corticosterone concentration. The corticoliberin activity of the pituitary stalk median eminence (SME) in MSG-treated animals was similar to that of litter-mate controls. Growth hormone releasing (somatoliberin) activity of the SME, tested after placing an anterolateral cut around the medial basal hypothalamus, was significantly lower in MSG-treated than in control animals. It was concluded that a substantial proportion of the somatoliberin neurones are found in the arcuate nucleus.

Ultrastructural Localization of Acetylcholinesterase in the Arcuate Nucleus and Median Eminence of the Rat

1977 ◽  
Vol 35 ◽  
pp. 440-441
Author(s):  
K.A. Carson ◽  
C.B. Nemeroff ◽  
M.S. Rone ◽  
J.S. Kizer ◽  
J.S. Hanker
Keyword(s):  
Choline Acetyltransferase ◽  
Median Eminence ◽  
Arcuate Nucleus ◽  
Cholinergic Neurons ◽  
Ultrastructural Localization ◽  
Male Rats ◽  
Neonatal Rats ◽  
Good Marker ◽  
Chemical Studies ◽  
High Doses

Biochemical, physiological, pharmacological, and more recently enzyme histo- chemical data have indicated that cholinergic circuits exist in the hypothalamus. Ultrastructural correlates of these pathways such as acetylcholinesterase (AchE) positive neurons in the arcuate nucleus (ARC) and stained terminals in the median eminence (ME) have yet to be described. Initial studies in our laboratories utilizing chemical lesioning and microdissection techniques coupled with microchemical and light microscopic enzyme histo- chemical studies suggested the existence of cholinergic neurons in the ARC which project to the ME (1). Furthermore, in adult male rats with Halasz deafferentations (hypothalamic islands composed primarily of the isolated ARC and the ME) choline acetyltransferase (ChAc) activity, a good marker for cholinergic neurons, was not significantly reduced in the ME and was only somewhat reduced in the ARC (2). Treatment of neonatal rats with high doses of monosodium 1-glutamate (MSG) results in a lesion largely restricted to the neurons of the ARC.

Distribution of β-Endorphin Immunoreactivity in the Arcuate Nucleus and Median Eminence of Postpartum Anestrus and Luteal Phase Cows

1992 ◽  
Vol 56 (3) ◽  
pp. 436-444 ◽  
Author(s):  
L. Steven Leshin ◽  
Laurie A. Rund ◽  
Robert R. Kraeling ◽  
Joe W. Crim ◽  
Terry E. Kiser
Keyword(s):  
Median Eminence ◽  
Luteal Phase ◽  
Arcuate Nucleus
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