Analysis of cell populations of normal and injured mouse lens epithelium. II. Contribution of local and migrating cells to wound healing

1976 ◽  
Vol 186 (1) ◽  
pp. 115-120 ◽  
Author(s):  
Nancy S. Rafferty
Keyword(s):  
Wound Healing ◽  
Lens Epithelium ◽  
Cell Populations ◽  
Mouse Lens ◽  
Migrating Cells

scholarly journals A Hierarchy of Proliferative Cells Exists in Mouse Lens Epithelium: Implications for Lens Maintenance

2006 ◽  
Vol 47 (7) ◽  
pp. 2997 ◽  
Author(s):  
Mingyuan Zhou ◽  
Joshua Leiberman ◽  
Jing Xu ◽  
Robert M. Lavker
Keyword(s):  
Lens Epithelium ◽  
Mouse Lens

scholarly journals Deletion of GLUT1 in mouse lens epithelium leads to cataract formation

2018 ◽  
Vol 172 ◽  
pp. 45-53 ◽  
Author(s):  
Aditi Swarup ◽  
Brent A. Bell ◽  
Jianhai Du ◽  
John Y.S. Han ◽  
Jamie Soto ◽  
...  
Keyword(s):  
Lens Epithelium ◽  
Cataract Formation ◽  
Mouse Lens

scholarly journals CD44 expression is developmentally regulated in the mouse lens and increases in the lens epithelium after injury

2010 ◽  
Vol 79 (2) ◽  
pp. 111-119 ◽  
Author(s):  
Vivek D. Desai ◽  
Yan Wang ◽  
Vladimir N. Simirskii ◽  
Melinda K. Duncan
Keyword(s):  
Lens Epithelium ◽  
Developmentally Regulated ◽  
Cd44 Expression ◽  
Mouse Lens

scholarly journals Loss of osteopontin perturbs the epithelial-mesenchymal transition in an injured mouse lens epithelium

2007 ◽  
Vol 87 (2) ◽  
pp. 130-138 ◽  
Author(s):  
Shizuya Saika ◽  
Kumi Shirai ◽  
Osamu Yamanaka ◽  
Ken-ichi Miyazaki ◽  
Yuka Okada ◽  
...  
Keyword(s):  
Epithelial Mesenchymal Transition ◽  
Lens Epithelium ◽  
Mesenchymal Transition ◽  
Mouse Lens

The cytoarchitecture of normal mouse lens epithelium

1972 ◽  
Vol 173 (2) ◽  
pp. 225-228 ◽  
Author(s):  
Nancy S. Rafferty
Keyword(s):  
Normal Mouse ◽  
Lens Epithelium ◽  
Mouse Lens

The Viscoelastic Properties of Mouse Embryonic Salivary Glands

2013 ◽  
Author(s):  
Ryan A. Koppes ◽  
Andrew K. Mason ◽  
Sarah B. Peters ◽  
Shayoni Ray ◽  
Melinda Larsen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Viscoelastic Properties ◽  
Stromal Cell ◽  
Cell Populations ◽  
Degenerative Diseases ◽  
Normal Organ ◽  
Pathological Conditions ◽  
Physical Cues ◽  
Tensional Homeostasis ◽  
Surrounding Extracellular Matrix

Normal organ development, function, and repair are coordinated by interactions between the epithelium and the surrounding stromal cell populations. Cellular function and homeostasis are controlled by an array of chemical and physical cues originating from the cells themselves and from the surrounding extracellular matrix (ECM). Both the endogenous cell population and ECM modulate and rely on the maintenance of basal level of tension within the tissue as a cue for growth and differentiation [1]. Furthermore, the loss of this tensional homeostasis is synonymous with many pathological conditions including; cancer, wound healing, and degenerative diseases [2].

scholarly journals Effect of Hypoxia on Gene Expression in Cell Populations Involved in Wound Healing

2019 ◽  
Vol 2019 ◽  
pp. 1-20 ◽  
Author(s):  
Sarah D’Alessandro ◽  
Andrea Magnavacca ◽  
Federica Perego ◽  
Marco Fumagalli ◽  
Enrico Sangiovanni ◽  
...  
Keyword(s):  
Gene Expression ◽  
Wound Healing ◽  
Endothelial Cells ◽  
Current Knowledge ◽  
Expression Profiles ◽  
Healing Process ◽  
Critical Role ◽  
Dermal Fibroblasts ◽  
Cell Populations ◽  
Wound Healing Process

Wound healing is a complex process regulated by multiple signals and consisting of several phases known as haemostasis, inflammation, proliferation, and remodelling. Keratinocytes, endothelial cells, macrophages, and fibroblasts are the major cell populations involved in wound healing process. Hypoxia plays a critical role in this process since cells sense and respond to hypoxic conditions by changing gene expression. This study assessed the in vitro expression of 77 genes involved in angiogenesis, metabolism, cell growth, proliferation and apoptosis in human keratinocytes (HaCaT), microvascular endothelial cells (HMEC-1), differentiated macrophages (THP-1), and dermal fibroblasts (HDF). Results indicated that the gene expression profiles induced by hypoxia were cell-type specific. In HMEC-1 and differentiated THP-1, most of the genes modulated by hypoxia encode proteins involved in angiogenesis or belonging to cytokines and growth factors. In HaCaT and HDF, hypoxia mainly affected the expression of genes encoding proteins involved in cell metabolism. This work can help to enlarge the current knowledge about the mechanisms through which a hypoxic environment influences wound healing processes at the molecular level.

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