Cell replication of mesenchymal elements in adult tissues. I. The replication and migration of mesenchymal cells in the adult rabbit dermis

1971 ◽  
Vol 169 (3) ◽  
pp. 593-611 ◽  
Author(s):  
Gordon I. Kaye ◽  
Linda F. Siegel ◽  
Robert R. Pascal
Keyword(s):  
Mesenchymal Cells ◽  
Adult Rabbit ◽  
Cell Replication ◽  
Adult Tissues ◽  
And Migration

scholarly journals Mesenchymal Cells Hold the Key to Immune Cell Recruitment to and Migration within Melanoma

2013 ◽  
Vol 133 (9) ◽  
pp. 2138-2140
Author(s):  
Kimberley A. Beaumont ◽  
Marcia A. Munoz ◽  
Wolfgang Weninger
Keyword(s):  
Immune Cell ◽  
Mesenchymal Cells ◽  
Cell Recruitment ◽  
And Migration ◽  
Immune Cell Recruitment

scholarly journals Keratinocyte Growth Factor Expression in the Mesenchymal Cells of Human Amnion*

1997 ◽  
Vol 82 (10) ◽  
pp. 3319-3323 ◽  
Author(s):  
M. Linette Casey ◽  
Paul C. MacDonald
Keyword(s):  
Growth Factor ◽  
Epithelial Cells ◽  
Transforming Growth Factor ◽  
Keratinocyte Growth Factor ◽  
Transforming Growth Factor Β ◽  
Mesenchymal Cells ◽  
Cell Replication ◽  
Human Amnion ◽  
Tetradecanoyl Phorbol Acetate ◽  
Amnion Epithelial Cells

Abstract Amnion epithelial and mesenchymal cells were separated by differential protease treatment, and the separated cells were maintained in monolayer culture. Keratinocyte growth factor (KGF) messenger RNA (mRNA) was readily detected by Northern analysis of amnion mesenchymal cell total RNA (10 μg) but not in amnion epithelial cells. Treatment of the amnion mesenchymal cells in serum-free medium with tetradecanoyl phorbol acetate (1 nm) caused an increase in the level of KGF mRNA. Forskolin treatment also caused an increase in KGF mRNA but not to the levels attained with tetradecanoyl phorbol acetate treatment. Dexamethasone (1 nm) treatment of these cells effected a reduction in the level of KGF mRNA. Prolonged maintenance of mesenchymal cells in serum-free medium also was associated with an increase in the level of KGF mRNA. Treatment with a variety of other agents, viz., interleukin (IL)-1, IL-6 plus or minus IL-6 soluble receptor, IL-11, oncostatin M , epidermal growth factor (EGF), and transforming growth factor-β did not modify the level of KGF mRNA. Treatment of amnion epithelial cells with KGF caused an increase in the rate of [3H]thymidine incorporation, but the rate of cell replication induced by KGF was less than that induced by treatment with EGF. Transforming growth factor-β treatment inhibited basal and EGF- and KGF-stimulated amnion epithelial cell replication. The findings of this study are indicative that KGF is expressed in human amnion mesenchymal cells, and that KGF may act on the epithelial cells of this tissue.

scholarly journals Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis

1994 ◽  
Vol 107 (12) ◽  
pp. 3569-3577 ◽  
Author(s):  
P.A. Hall ◽  
P.J. Coates ◽  
B. Ansari ◽  
D. Hopwood
Keyword(s):  
Gastrointestinal Tract ◽  
Epithelial Cells ◽  
Cell Loss ◽  
Cell Number ◽  
Cellular Migration ◽  
Central Feature ◽  
Apoptotic Bodies ◽  
Migration Routes ◽  
Adult Tissues ◽  
And Migration

The regulation of cell number in adult tissues is determined by the balance of cell production and cell loss. In the gastrointestinal tract, where there are well defined zones of proliferation and migration of both epithelial cells and associated fibroblasts, it is widely held that cell loss occurs by shedding into the gut lumen. Since the evidence for this is not compelling, we investigated the distribution and amount of apoptosis in the normal mammalian gut. In the stomach, small intestine and colon of rodents and man, there is a small number of apoptotic bodies in the epithelium and in the immediate sub-epithelial connective tissue. Engulfment by adjacent epithelial cells and sub-epithelial macrophages accounts for the removal of apoptotic bodies. Apoptotic bodies are not randomly distributed but are found towards the distal end of the known cellular migration routes of both epithelial and mesenchymal cells. Furthermore, consideration of the absolute numbers of apoptotic bodies, their rapid clearance and the dimensions of the small intestinal villi and colonic crypts indicates that the cell loss in the normal murine intestine can largely be explained on the basis of the observed apoptosis. Despite being inconspicuous in histological material, apoptosis probably accounts for the bulk of cell loss in the gut and is a central feature of the regulation of cell number in adult tissues.

Modulation of cellular polarization and migration by ephrin/Eph signal-mediated boundary formation

2017 ◽  
Vol 9 (12) ◽  
pp. 934-946
Author(s):  
Sahar Javaherian ◽  
Elisa D’Arcangelo ◽  
Benjamin Slater ◽  
Camila Londono ◽  
Bin Xu ◽  
...  
Keyword(s):  
Embryo Development ◽  
Boundary Formation ◽  
Adult Tissues ◽  
Cell Organization ◽  
And Migration ◽  
Cellular Polarization

Compartment boundaries are essential for ensuring proper cell organization during embryo development and in adult tissues, yet the mechanisms underlying boundary establishment are not completely understood.

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