The character of the wall of the smaller blood vessels in the bone marrow of the frog, with special reference to the question of erythrocyte origin

1927 ◽  
Vol 35 (3) ◽  
pp. 161-183 ◽  
Author(s):  
H. E. Jordan ◽  
J. P. Baker
Keyword(s):  
Bone Marrow ◽  
Special Reference ◽  
Blood Vessels

scholarly journals Flavonoid genistein protects bone marrow sinusoidal blood vessels from damage by methotrexate therapy in rats

2018 ◽  
Vol 234 (7) ◽  
pp. 11276-11286 ◽  
Author(s):  
Mohammadhossein Hassanshahi ◽  
Yu‐Wen Su ◽  
Samira Khabbazi ◽  
Chia‐Ming Fan ◽  
Ke‐Ming Chen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Blood Vessels ◽  
Methotrexate Therapy

The combined application of rat bone marrow mesenchymal stem cells and bioceramic materials in the regeneration of dental pulp-like tissues

2020 ◽  
Author(s):  
Ruixue Wen ◽  
Xin Wang ◽  
Yongchao Lu ◽  
Yi Du ◽  
Xijiao Yu
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Blood Vessels ◽  
Collagen Scaffold ◽  
Inflammatory Cells ◽  
Combined Application ◽  
Marrow Mesenchymal Stem Cells ◽  
Good Biocompatibility ◽  
Rat Bone

Abstract Background: To observe the effects of combined application of rat bone marrow mesenchymal stem cells (rBMSCs) and a bioceramic material on pulp-like tissue formation. Methods: Rat incisor root fragments without pulp tissues were prepared and filled with a collagen scaffold seeded with rBMSCs, while one side of the root segment was covered by a bioceramic material (iRoot BP). After culture for 12 h, the root fragments were implanted subcutaneously for 3 months. Hematoxylin and eosin (HE) staining was applied to observe biocompatibility and the formation of pulp-like tissues. Incisor root fragments were divided into three parts (BP1/3 , M1/3, and D1/3) to analyze the area and number of new vessels. Immunohistochemical staining of neuroendocrine marker PGP9.5, dentin sialophosphoprotein ( DSPP ), and vascular endothelial growth factor (VEGF) was applied to observe the formation of pulp-like tissues. Root fragments filled with the collagen scaffold only were used as a control. Results: Three months after implantation, root fragments were collected, which were surrounded by a transparent tissue membrane with a good blood supply. The root fragment cavity was filled with pink vascularized pulp-like tissue. According to HE results, iRoot BP had good biocompatibility with new pulp-like tissues and few infiltrating inflammatory cells. Increases in the number and area of new blood vessels were observed in BP1/3 compared with the other two parts. Expression of PGP9.5 and DSPP showed that the newly formed tissues were similar to normal pulp tissues. Conclusion: iRoot BP has good biocompatibility and increases the number and area of new blood vessels. The combined application of stem cells and bioceramic materials may be a better method for pulp revascularization .

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