The anatomy of a double pig, Syncephalus thoracopagus, with especial consideration of the genetic significance of the circulatory apparatus

1917 ◽  
Vol 12 (1) ◽  
pp. 177-191 ◽  
Author(s):  
Eben Carey
Genetics ◽  
1992 ◽  
Vol 131 (2) ◽  
pp. 461-469 ◽  
Author(s):  
F W Schnell ◽  
C C Cockerham

Abstract In this article we investigate multiplicative effects between genes in relation to heterosis. The extensive literature on heterosis due to multiplicative effects between characters is reviewed, as is earlier work on the genetic description of heterosis. A two-locus diallelic model of arbitrary gene action is used to derive linear parameters for two multiplicative models. With multiplicative action between loci, epistatic effects are nonlinear functions of one-locus effects and the mean. With completely multiplicative action, the mean and additive effects form similar restrictions for all the rest of the effects. Extensions to more than two loci are indicated. The linear parameters of various models are then used to describe heterosis, which is taken as the difference between respective averages of a cross (F1) and its two parent populations (P). The difference (F2 - P) is also discussed. Two parts of heterosis are distinguished: part I arising from dominance, and part II due to additive x additive (a x a)-epistasis. Heterosis with multiplicative action between loci implies multiplicative accumulation of heterosis present at individual loci in part I, in addition to multiplicative (a x a)-interaction in part II. Heterosis with completely multiplicative action can only be negative (i.e., the F1 values must be less than the midparent), but the difference (F2 - P) can be positive under certain conditions. Heterosis without dominance can arise from multiplicative as well as any other nonadditive action between loci, as is exemplified by diminishing return interaction. The discussion enlarges the scope in various directions: the genetic significance of multiplicative models is considered.(ABSTRACT TRUNCATED AT 250 WORDS)


Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1123
Author(s):  
Carole Ayoub Moubareck

Human milk represents a cornerstone for growth and development of infants, with extensive array of benefits. In addition to exceptionally nutritive and bioactive components, human milk encompasses a complex community of signature bacteria that helps establish infant gut microbiota, contributes to maturation of infant immune system, and competitively interferes with pathogens. Among bioactive constituents of milk, human milk oligosaccharides (HMOs) are particularly significant. These are non-digestible carbohydrates forming the third largest solid component in human milk. Valuable effects of HMOs include shaping intestinal microbiota, imparting antimicrobial effects, developing intestinal barrier, and modulating immune response. Moreover, recent investigations suggest correlations between HMOs and milk microbiota, with complex links possibly existing with environmental factors, genetics, geographical location, and other factors. In this review, and from a physiological and health implications perspective, milk benefits for newborns and mothers are highlighted. From a microbiological perspective, a focused insight into milk microbiota, including origins, diversity, benefits, and effect of maternal diet is presented. From a metabolic perspective, biochemical, physiological, and genetic significance of HMOs, and their probable relations to milk microbiota, are addressed. Ongoing research into mechanistic processes through which the rich biological assets of milk promote development, shaping of microbiota, and immunity is tackled.


1902 ◽  
Vol 2 (11-12) ◽  
pp. 631-671
Author(s):  
N. I. Notovshchikov

Ad. Schmidt (321) establishes a connection between the existence of small dilated cutaneous veins in the area of cardiac dullness and along the line of attachment of the diaphragm with some forms of cardiac neuroses.


1903 ◽  
Vol 3 (7-8) ◽  
pp. 407-414
Author(s):  
N. I. Kotovshchikov

The article provides an overview of the work on diagnostics, particular pathology of therapy and diseases of the circulatory apparatus for 1901.


1930 ◽  
Vol 76 (315) ◽  
pp. 632-640 ◽  
Author(s):  
Alexander George Gibson

Mental change in cardiac disease, though a rare complication, is a subject that can be properly and usefully discussed at a meeting of psychiatrists at which physicians are asked to take part. For while the physician may be able to assess accurately the physical defect in the circulatory apparatus, he is trained only in a rough-and-ready way to interpret different types of character, and the way in which they react to disease, and is liable to go astray in his interpretation of mental states. There is also this advantage—that in the present state of uncertainty as to the physical basis of mental disease we cannot look at the subject from too many points of view.


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