Porcine enamel matrix derivative enhances trabecular bone regeneration during wound healing of injured rat femur

2001 ◽  
Vol 264 (4) ◽  
pp. 438-446 ◽  
Author(s):  
Fumi Kawana ◽  
Yoshiko Sawae ◽  
Takako Sahara ◽  
Shinpei Tanaka ◽  
Kazuhiro Debari ◽  
...  
Keyword(s):  
Wound Healing ◽  
Bone Regeneration ◽  
Trabecular Bone ◽  
Rat Femur ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Matrix Derivative

scholarly journals Guided bone regeneration using enamel matrix derivative for implant treatments: Case series

2019 ◽  
Vol 39 (1-2) ◽  
pp. 53-61
Author(s):  
Yoshiyuki Wada ◽  
Masazumi Yoshitani ◽  
Motomasa Itabashi ◽  
Harunori Yoshimura ◽  
Itaru Mikami
Keyword(s):  
Bone Regeneration ◽  
Case Series ◽  
Guided Bone Regeneration ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Matrix Derivative

scholarly journals Angiogenic Marker Alterations Following Enamel Matrix Derivative Treatment: A Human Study

2012 ◽  
Vol 2 (1) ◽  
pp. 8
Author(s):  
Onur Özçelik ◽  
Gülşah Seydaoğlu ◽  
Murat Cömert ◽  
Eftal Yılmaz ◽  
M. Cenk Haytaç
Keyword(s):  
Wound Healing ◽  
Inflammatory Infiltrate ◽  
Soft Tissues ◽  
Human Study ◽  
Gingival Tissue ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
And Control ◽  
Angiogenic Marker ◽  
Matrix Derivative

Aim: The aim of this immunohistochemical study was to assess the expression of angiogenic markers (vascular endothelial growth factor (VEGF) and microvessel density (MVD) in enamel matrix derivative (EMD) treated retromolar soft tissues to gain further insights into the biological mechanisms involved in wound healing and EMD treatment. Methodology: In twenty healthy volunteers, gingival biopsies were obtained from the distal wedge operations of test (EMD-applied) and control sites. EMD was applied into the test sites during the operation. At the 15th post-operative day, the sample sites were re-entered and gingival tissue samples were obtained from both test and control sites. A total of 80 samples for each sites were analyzed by immunohistochemistry for inflammatory infiltrate, expression of VEGF and MVD. Results: Despite similar post-operative inflammatory infiltrate, it was found that EMD- applied sites had statistically higher VEGF-A and VEGF-C expression and MVD compared to the controls on the 15th day. (p <0.0001 for each) Conclusions: This study supports that EMD has an angiogenic potential. The findings of this immunohistochemical analysis may help to gain insight into the angiogenic effects of EMD during the early phases of wound healing.  How to cite this article: Özçelik O, Seydaoğlu G, Cömert M, Yılmaz E, Haytaç MC. Angiogenic Marker Alterations Following Enamel Matrix Derivative Treatment: A Human Study. Int Dent Res 2012;2:8-16. Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

Proline-Rich Peptide Mimics Effects of Enamel Matrix Derivative on Rat Oral Mucosa Incisional Wound Healing

2015 ◽  
Vol 86 (12) ◽  
pp. 1386-1395 ◽  
Author(s):  
Oscar Villa ◽  
Johan C. Wohlfahrt ◽  
Ibrahimu Mdla ◽  
Christiane Petzold ◽  
Janne E. Reseland ◽  
...  
Keyword(s):  
Wound Healing ◽  
Oral Mucosa ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Peptide Mimics ◽  
Proline Rich Peptide ◽  
Matrix Derivative

Effect of Enamel Matrix Derivative on Periodontal Wound Healing and Regeneration in an Osteoporotic Model

2014 ◽  
Vol 85 (11) ◽  
pp. 1603-1611 ◽  
Author(s):  
Richard J. Miron ◽  
Lingfei Wei ◽  
Shuang Yang ◽  
Oana M. Caluseru ◽  
Anton Sculean ◽  
...  
Keyword(s):  
Wound Healing ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Periodontal Wound Healing ◽  
Matrix Derivative

scholarly journals The Applications of Enamel Matrix Derivative in Implant Dentistry: A Narrative Review

Materials ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 3045
Author(s):  
Alice Alberti ◽  
Luca Francetti ◽  
Silvio Taschieri ◽  
Stefano Corbella
Keyword(s):  
Clinical Trials ◽  
Bone Regeneration ◽  
Randomized Clinical Trials ◽  
Periodontal Regeneration ◽  
Case Series ◽  
Titanium Implants ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Implant Placement ◽  
Matrix Derivative

Enamel matrix derivative (EMD) has been successfully used for periodontal regeneration in intrabony defects. Recently, its use for peri-implant bone regeneration has also been hypothesized. The aim of this paper is to review preclinical and clinical studies investigating the use of EMD in correspondence with titanium implants, alone or as an adjunct to other biomaterials. Clinical trials and case series with more than five cases were included. Seven in vitro studies evaluated the effect of EMD, placed on titanium surfaces: An increase in proliferation and viability of osteoblasts was observed in all but two studies. An increase in TGF-β1 and osteocalcin production, alkaline phosphatase activity, and angiogenesis was also reported. Nine animal studies investigated the use of EMD at implant placement or for bone regeneration of peri-implant bone defects, and some of them reported a significant increase in bone formation or bone-to-implant contact. In four of eleven clinical trials on humans, EMD was successfully used at implant placement. The other seven evaluated the use of EMD in protocols for the treatment of peri-implantitis. In conclusion, the results of EMD seem promising, but further randomized clinical trials are needed to evaluate its efficacy.

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