Enhancing capacity for freshwater conservation at the genetic level: a demonstration using three stream macroinvertebrates

2016 ◽  
Vol 27 (2) ◽  
pp. 452-461 ◽  
Author(s):  
Hannah C. Macdonald ◽  
Steve J. Ormerod ◽  
Michael W. Bruford
Keyword(s):  
Freshwater Conservation ◽  
Stream Macroinvertebrates ◽  
Genetic Level

The Relationship Between Personality and Self-Report Abilities

2011 ◽  
Vol 32 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Julie Aitken Schermer ◽  
Andrew M. Johnson ◽  
Philip A. Vernon ◽  
Kerry L. Jang
Keyword(s):  
Interpersonal Relationships ◽  
Self Report ◽  
Personality Factors ◽  
Personality Factor ◽  
Factor Scores ◽  
Environmental Correlations ◽  
Ability Factor ◽  
Genetic Level ◽  
The Relationship ◽  
Common Environmental Factor

The relationship between self-report abilities and personality was examined at both the phenotypic (zero-order) level as well as at the genetic and environmental levels. Twins and siblings (N = 516) completed self-report ability and personality questionnaires. A factor analysis of the ability questions revealed 10 factors, including politics, interpersonal relationships, practical tasks, intellectual pursuits, academic skills, entrepreneur/business, domestic skills, vocal abilities, and creativity. Five personality factors were examined, including extraversion, conscientiousness, dependence, aggression, and openness. At the phenotypic level, the correlations between the ability factor scores and personality factor scores ranged from 0 to .60 (between political abilities and extraversion). The relationship between the two areas at the genetic level was found to range between –.01 and .60; the environmental correlations ranged from –.01 to .48. The results suggest that some of the self-report ability scores are related to self-report personality, and that some of these observed relationships may have a common genetic basis while others are from a common environmental factor.

The First Half of the Twentieth Century

2018 ◽  
Author(s):  
Alexander Gillespie
Keyword(s):  
Habitat Management ◽  
Social Economic ◽  
Chemical Pollution ◽  
Freshwater Conservation ◽  
The Great Depression ◽  
Negative Results ◽  
The Social ◽  
The World ◽  
The One ◽  
The Welfare State

The years between 1900 and 1945 were very difficult for humanity. In this period, not only were there two world wars to survive but also some of the worst parts of the social, economic, and environmental challenges of sustainable development all began to make themselves felt. The one area in which progress was made was in the social context, in which the rights of workers and the welfare state expanded. The idea of ‘development’, especially for the developing world, also evolved in this period. In the economic arena, the world went up, and then crashed in the Great Depression, producing negative results that were unprecedented. In environmental terms, positive templates were created for some habitat management, some wildlife law, and parts of freshwater conservation. Where there was not so much success was with regard to air and chemical pollution.

Shared genetic architecture across psychiatric disorders

2021 ◽  
pp. 1-7
Author(s):  
Andrew D. Grotzinger
Keyword(s):  
Risk Factors ◽  
Psychiatric Disorders ◽  
Genetic Correlations ◽  
Fine Grained ◽  
Level Data ◽  
Symptom Level ◽  
Genetic Level ◽  
Genetic Signal ◽  
Family Based ◽  
Shared Genetic

Abstract Psychiatric disorders overlap substantially at the genetic level, with family-based methods long pointing toward transdiagnostic risk pathways. Psychiatric genomics has progressed rapidly in the last decade, shedding light on the biological makeup of cross-disorder risk at multiple levels of analysis. Over a hundred genetic variants have been identified that affect multiple disorders, with many more to be uncovered as sample sizes continue to grow. Cross-disorder mechanistic studies build on these findings to cluster transdiagnostic variants into meaningful categories, including in what tissues or when in development these variants are expressed. At the upper-most level, methods have been developed to estimate the overall shared genetic signal across pairs of traits (i.e. single-nucleotide polymorphism-based genetic correlations) and subsequently model these relationships to identify overarching, genomic risk factors. These factors can subsequently be associated with external traits (e.g. functional imaging phenotypes) to begin to understand the makeup of these transdiagnostic risk factors. As psychiatric genomic efforts continue to expand, we can begin to gain even greater insight by including more fine-grained phenotypes (i.e. symptom-level data) and explicitly considering the environment. The culmination of these efforts will help to inform bottom-up revisions of our current nosology.

scholarly journals Altering the Stereoselectivity of Whole-Cell Biotransformations via the Physicochemical Parameters Impacting the Processes

Catalysts ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 781
Author(s):  
Agnieszka Raczyńska ◽  
Joanna Jadczyk ◽  
Małgorzata Brzezińska-Rodak
Keyword(s):  
Culture Conditions ◽  
Biologically Active ◽  
Enantiomerically Pure ◽  
Whole Cells ◽  
Chiral Compounds ◽  
Physicochemical Factors ◽  
Pure Compounds ◽  
Genetic Level ◽  
Prochiral Ketones ◽  
Optically Pure

The enantioselective synthesis of organic compounds is one of the great challenges in organic synthetic chemistry due to its importance for the acquisition of biologically active derivatives, e.g., pharmaceuticals, agrochemicals, and others. This is why biological systems are increasingly applied as tools for chiral compounds synthesis or modification. The use of whole cells of “wild-type” microorganisms is one possible approach, especially as some methods allow improving the conversion degrees and controlling the stereoselectivity of the reaction without the need to introduce changes at the genetic level. Simple manipulation of the culture conditions, the form of a biocatalyst, or the appropriate composition of the biotransformation medium makes it possible to obtain optically pure products in a cheap, safe, and environmentally friendly manner. This review contains selected examples of the influence of physicochemical factors on the stereochemistry of the biocatalytic preparation of enantiomerically pure compounds, which is undertaken through kinetically controlled separation of their racemic mixtures or reduction of prochiral ketones and has an effect on the final enantiomeric purity and enantioselectivity of the reaction.

scholarly journals Delayed diagnosis of Peutz–Jeghers syndrome due to pathological information loss or mistake in family/personal history

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Yu-Liang Jiang ◽  
Xiao-Dong Xu ◽  
Bai-Rong Li ◽  
En-Da Yu ◽  
Zi-Ye Zhao ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Novel Mutation ◽  
Delayed Diagnosis ◽  
Personal History ◽  
Pathological Examination ◽  
The Novel ◽  
Novel Mutations ◽  
The Family ◽  
Genetic Level ◽  
Peutz Jeghers Syndrome

Abstract Objective To report Peutz–Jeghers syndrome (PJS) cases with non-definitive clues in the family or personal history and finally diagnosed through pathological examination and STK11 gene mutation test. Clinical presentation and intervention PJS was suspected in 3 families with tortuous medical courses. Two of them had relatives departed due to polyposis or colon cancer without pathological results, and the other one had been diagnosed as hyperplastic polyposis before. Diagnosis of PJS was confirmed by endoscopy and repeated pathological examinations, and the STK11 mutation test finally confirmed the diagnosis at genetic level, during which 3 novel mutation were detected (536C > A, 373_374insA, 454_455insGGAGAAGCGTTTCCCAGTGTGCC). Conclusion Early diagnosis of PJS is important and may be based on a family history with selective features among family members, and the pathological information is the key. The novel mutations also expand the STK11 variant spectrum.

scholarly journals A comparative study on the indicative function of species and traits structure of stream macroinvertebrates to human disturbances

2021 ◽  
Vol 129 ◽  
pp. 107939
Author(s):  
Wanxiang Jiang ◽  
Baozhu Pan ◽  
Xiaoming Jiang ◽  
Peng Shi ◽  
Penghui Zhu ◽  
...  
Keyword(s):  
Comparative Study ◽  
Human Disturbances ◽  
Stream Macroinvertebrates

scholarly journals A novel nonsense variant of the AGXT identified in a Chinese family: special variant research in the Chinese reference genome

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Chang Bao Xu ◽  
Xu Dong Zhou ◽  
Hong En Xu ◽  
Yong Li Zhao ◽  
Xing Hua Zhao ◽  
...  
Keyword(s):  
High Throughput Sequencing ◽  
Reference Genome ◽  
Genetic Diagnosis ◽  
Primary Hyperoxaluria ◽  
Missense Variant ◽  
Population Heterogeneity ◽  
Chinese Family ◽  
Pathogenic Variants ◽  
Variation Database ◽  
Genetic Level

Abstract Background Primary hyperoxaluria(PH)is a rare autosomal recessive genetic disease that contains three subtypes (PH1, PH2 and PH3). Approximately 80% of PH patients has been reported as subtype PH1, this subtype of PH has been related to a higher risk of renal failure at any age. Several genetic studies indicate that the variants in gene AGXT are responsible for the occurrence of PH1. However, the population heterogeneity of the variants in AGXT makes the genetic diagnosis of PH1 more challenging as it is hard to locate each specific variant. It is valuable to have a complete spectrum of AGXT variants from different population for early diagnosis and clinical treatments of PH1. Case presentation In this study, We performed high-throughput sequencing and genetic analysis of a 6-year-old male PH1 patient from a Chinese family. Two variants (c.346G > A: p.Gly116Arg; c.864G > A: p.Trp288X) of the gene AGXT were identified. We found a nonsense variant (c.864G > A: p.Trp288X) that comes from the proband’s mother and has never been reported previously. The other missense variant (c.346G > A: p.Gly116Arg) was inherited from his father and has been found previously in a domain of aminotransferase, which plays an important role in the function of AGT protein. Furthermore, we searched 110 pathogenic variants of AGXT that have been reported worldwide in healthy local Chinese population, none of these pathogenic variants was detected in the local genomes. Conclusions Our research provides an important diagnosis basis for PH1 on the genetic level by updating the genotype of PH1 and also develops a better understanding of the variants in AGXT by broadening the variation database of AGXT according to the Chinese reference genome.

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