A novel phenolic compounds delivery system: Oral films with extract from camu‐camu industrial residue

2022 ◽  
pp. 52092
Author(s):  
Carla Alves Monaco Lourenço ◽  
Vitor Augusto Garcia ◽  
Josiane Gonçalves Borges ◽  
Cristiana Maria Pedroso Yoshida ◽  
Fernanda Maria Vanin ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Delivery System ◽  
Industrial Residue ◽  
Oral Films

scholarly journals Extraction of phenolic compounds from Iraqi Coriandrum Sativum L. and loaded on copolymeric hydrogels and examine there as drug delivery system and antioxidant

2021 ◽  
Vol 2063 (1) ◽  
pp. 012001
Author(s):  
Ula Ali Sadoun ◽  
Zainab Shakir Al-Ali ◽  
Athir Mahmood Haddad
Keyword(s):  
Drug Delivery ◽  
Phenolic Compounds ◽  
Drug Delivery System ◽  
Delivery System ◽  
Coriandrum Sativum ◽  
Total Flavonoids ◽  
Distilled Water ◽  
Total Phenols ◽  
Phenolic Extract ◽  
Phenolic Extracts

Abstract The phenolic extracts for leaves and stems (L+S) parts and leaves (L) part of Iraqi Coriandrum Sativum L. and their total phenols, total tannins and total flavonoids are described. Three copolymeric hydrogels prepared and loaded with phenolic extract 4 (U1-U3). The HPLC results show three phenolic compounds, while the GC-Mass results show one phenolic compound and four non-phenolic compounds. Gained results showed that there are significant (P < 0.05) variations in total phenols (9.822 ± 0.634−4.015 ± 0.118 mg GAE/g DW), total flavonoids (8.112 ± 0.115−2.811 ± 0.371 mg QE/g DW) and total condensed tannin (4.245 ± 0.276−1.135 ± 0.091 mg QE/g DW) contents for all phenolic extracts. The swelling rate for (U1-U3) in distilled water, the SGF, and the SIF was estimated. The maximum swelling was observed in copolymeric hydrogels at pH 6.9 in distilled water. The IC50 values of radical scavenging activity of the phenolic extracts 4, 8 and phenolic extract 4 released from copolymeric hydrogels (U1-U3) show varied significantly (P < 0.05). Our results indicated that Iraqi Coriandrum Sativum L. could constitute a rich and novel source of natural antioxidants. When it loaded on, copolymeric hydrogels could be used as a drug delivery system.

Açaí seeds: An unexplored agro-industrial residue as a potential source of lipids, fibers, and antioxidant phenolic compounds

2021 ◽  
Vol 161 ◽  
pp. 113204
Author(s):  
Priscilla Siqueira Melo ◽  
Miriam Mabel Selani ◽  
Regina Helena Gonçalves ◽  
Jennifer de Oliveira Paulino ◽  
Adna Prado Massarioli ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Potential Source ◽  
Industrial Residue

scholarly journals Reduction of antinutrients and maintenance of bioactive compounds in flour from agro-industrial residue of acerola (Malpighia emarginata D.C.)

2020 ◽  
Vol 9 (9) ◽  
pp. e980998054
Author(s):  
Viviane Martins Barros ◽  
Jane de Jesus da Silveira Moreira ◽  
Maria Terezinha Santos Leite Neta ◽  
Tatiana Pacheco Nunes ◽  
Evelyn Horanyi Silva Costa Vasvary ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Volatile Compounds ◽  
Bioactive Compounds ◽  
Physicochemical Characterization ◽  
Significant Loss ◽  
Alternative Source ◽  
Malpighia Emarginata ◽  
Industrial Residue ◽  
Drying Conditions ◽  
The Impact

This study was aimed at analyzing the reduction of antinutrients, preserving apparent phenolic compounds in acerola flour residue by employing drying techniques. The optimal drying conditions were then determined in the wet residue, analyzing antinutrient concentration and apparent phenolic compounds in the residue and subsequently in the acerola flour. The physicochemical characterization of the flour was carried out, determining its antioxidant activity, thereby assessing the impact of the drying process on the composition of volatile compounds. The optimal drying conditions were found for a temperature of 65ºC for 120 min, reducing water activity by 0.3 and moisture content by 13.89%, which are considered adequate conditions for flours. Carbohydrate content represented 68.72 g/100g, while proteins represented 12.55 g/100g of the centesimal composition of the flour. Significant reductions (p<0.5) of antinutrients were observed in saponins (35.9%), followed by phytates (32.8%) and condensed tannins (11.52%). Losses of 18.7% of apparent phenolic compounds were also observed. For volatile compounds, a significant loss of esters with a significant increase in alcohol content was noticed. Thermal processing reduced aroma complexity, but maintained important bioactive compounds, such as linalool and caryophyllene. In this regard, taking into account the results of the present study, the agro-industrial residue of acerola proved to be an alternative source of antioxidants with a reduced antinutritional impact and may be incorporated as an ingredient in the formulation of new food products. Moreover, this agro-industrial residue reduces the environmental impact caused by the fruit pulp processing industry.

1004: In-Vivo Transfection of the Rat Corpus Cavernosum Using a Non-Viral, Linear Polyethylenimine Gene Delivery System: A Novel Application

2006 ◽  
Vol 175 (4S) ◽  
pp. 323-324 ◽  
Author(s):  
Joseph Dall'era ◽  
Sweaty Koul ◽  
Jesse Mills ◽  
Jeremy Myers ◽  
Randall B. Meacham ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Corpus Cavernosum ◽  
Gene Delivery System ◽  
System A ◽  
In Vivo Transfection ◽  
Linear Polyethylenimine

First clinical experience with the Multi-LOC multiple stent delivery system for focal stenting in long femoro-popliteal lesions

VASA ◽  
2017 ◽  
Vol 46 (6) ◽  
pp. 452-461 ◽  
Author(s):  
Klaus Amendt ◽  
Ulrich Beschorner ◽  
Matthias Waliszewski ◽  
Martin Sigl ◽  
Ralf Langhoff ◽  
...  
Keyword(s):  
Observational Study ◽  
Clinical Experience ◽  
Delivery System ◽  
Target Lesion ◽  
Lesion Length ◽  
Elastic Recoil ◽  
Delivery Device ◽  
Clinical Assessments ◽  
Balloon Catheters ◽  
Considerable Length

Abstract. Background: The purpose of this observational study is to report the six-month clinical outcomes with a new multiple stent delivery system in patients with femoro-popliteal lesions. Patients and methods: The LOCOMOTIVE study is an observational multicentre study with a primary endpoint target lesion revascularization (TLR) rate at six months. Femoro-popliteal lesions were prepared with uncoated and/or paclitaxel-coated peripheral balloon catheters. When flow limiting dissections, elastic recoil or recoil due to calcification required stenting, up to six short stents per delivery device, each 13 mm in length, were implanted. Sonographic follow-ups and clinical assessments were scheduled at six months. Results: For this first analysis, a total of 75 patients 72.9 ± 9.2 years of age were enrolled. The majority of the 176 individually treated lesions were in the superficial femoral artery (76.2 %, 134/176) whereas the rate of TASC C/D amounted to 51.1 % (90/176). The total lesion length was 14.5 ± 9.0 cm with reference vessel diameters of 5.6 ± 0.7 mm. Overall 47 ± 18 % of lesion lengths could be saved from stenting. At six months, the patency was 90.7 % (68/75) and all-cause TLR rates were 5.3 % (4/75) in the overall cohort. Conclusions: The first clinical experience at six months suggests that the MSDS strategy was safe and effective to treat femoro-popliteal lesions of considerable length (14.5 ± 9.0 cm). Almost half of the lesion length could be saved from stenting while patency was high and TLR rates were acceptably low.

Combining a global health budget with a market-driven delivery system: Can it be done?

1993 ◽  
Vol 48 (3) ◽  
pp. 270-276 ◽  
Author(s):  
Jeff Bingaman ◽  
Robert G. Frank ◽  
Carrie L. Billy
Keyword(s):  
Global Health ◽  
Delivery System ◽  
Health Budget ◽  
Market Driven
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