Biodegradable hot melt adhesive based on partially saponified polyvinyl acetate/cellulose diacetate blend

2021 ◽  
pp. 50867
Author(s):  
Yong‐Ho Kim ◽  
Jin‐Hyok Ri ◽  
In‐Ho Pak ◽  
Yong‐Chol Ri ◽  
Ju‐Hyon Yu ◽  
...  
Keyword(s):  
Polyvinyl Acetate ◽  
Cellulose Diacetate ◽  
Hot Melt

scholarly journals Recovery of cellulose diacetate from cigarette butts and its use for formulation of hot melt adhesive

2021 ◽  
Author(s):  
Yong-Ho Kim ◽  
Kwang-Il To ◽  
Chol-Yi Om ◽  
Yong-Su Hwang ◽  
Myong-Il Jo ◽  
...  
Keyword(s):  
Cellulose Diacetate ◽  
Cigarette Butts ◽  
Hot Melt

scholarly journals Improving interface adhesion of magnetic particle modified EVA hot melt adhesive through introduction of a thermodynamically compatible component

RSC Advances ◽  
2017 ◽  
Vol 7 (58) ◽  
pp. 36382-36391 ◽  
Author(s):  
Xiaobin Lu ◽  
Hongguo Zhao ◽  
Chunhui Feng ◽  
Qian Chen ◽  
Zhao Zhang ◽  
...  
Keyword(s):  
Magnetic Particle ◽  
Polyvinyl Acetate ◽  
Interface Adhesion ◽  
Melt Adhesives ◽  
Hot Melt

Fe3O4 particles were surface coated with a layer of polyvinyl acetate (PVAc), which could improve their compatibility with EVA composite hot melt adhesives and then further induce EVA segments to orientate.

scholarly journals Processing of Polyvinyl Acetate Phthalate in Hot-Melt Extrusion—Preparation of Amorphous Solid Dispersions

Pharmaceutics ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 337 ◽  
Author(s):  
Marius Monschke ◽  
Kevin Kayser ◽  
Karl G. Wagner
Keyword(s):  
Polyvinyl Acetate ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Hot Melt Extrusion ◽  
Extrusion Process ◽  
Dissolution Time ◽  
Melt Extrusion ◽  
Amorphous Solid Dispersions ◽  
Ph Dependent ◽  
Hot Melt

The preparation of amorphous solid dispersions (ASDs) is a suitable approach to overcome solubility-limited absorption of poorly soluble drugs. In particular, pH-dependent soluble polymers have proven to be an excellently suitable carrier material for ASDs. Polyvinyl acetate phthalate (PVAP) is a polymer with a pH-dependent solubility, which is as yet not thoroughly characterized regarding its suitability for a hot-melt extrusion process. The objective of this study was to assess the processability of PVAP within a hot-melt extrusion process with the aim of preparing an ASD. Therefore, the influence of different process parameters (temperature, feed-rate) on the degree of degradation, solid-state and dissolution time of the neat polymer was studied. Subsequently, drug-containing ASDs with indomethacin (IND) and dipyridamole (DPD) were prepared, respectively, and analyzed regarding drug content, solid-state, non-sink dissolution performance and storage stability. PVAP was extrudable in combination with 10% (w/w) PEG 3000 as plasticizer. The dissolution time of PVAP was only slightly influenced by different process parameters. For IND no degradation occurred in combination with PVAP and single phased ASDs could be generated. The dissolution performance of the IND-PVAP ASD at pH 5.5 was superior and at pH 6.8 equivalent compared to commonly used polymers hydroxypropylmethylcellulose acetate succinate (HPMCAS) and Eudragit L100-55.

Technological Advancements in Oral Films

2019 ◽  
Vol 9 (01) ◽  
pp. 15-20
Author(s):  
B Pandey ◽  
A B Khan
Keyword(s):  
3D Printing ◽  
Historical Background ◽  
Poorly Soluble Drugs ◽  
Modern Approach ◽  
Poorly Soluble ◽  
Critical Process Parameters ◽  
Biopharmaceutical Properties ◽  
Oral Films ◽  
Hot Melt ◽  
Modern Technologies

The aim of the review was to explore the necessity, advantages and different techniques of oral films for enhancing solubility of poorly soluble drugs with an emphasis on the newer, state-of the art technologies, such as 3D printing and hot-melt extrusion (HME). The historical background of oral films is presented along with the regularly used techniques. The modern approach of quality-by-design (QbD) is unravelled, identifying appropriate critical process parameters (CPP) and applied to oral films. A section is devoted modern technologies such as 3D printing and HME of oral films. Oral films are innovative formulations by which poorly soluble drugs have been founds to give positive results in enhancing their solubility and dissolution characteristics. With modern sophisticated techniques, precise mass production of oral films has been given a thrust. Oral films have better patient compliance, improved biopharmaceutical properties, improved efficacy, and better safety. By applying QbD and implementation of modern technologies the newer generation of oral films are yielding promising results

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