Fabrication of tough, self‐recoverable, and electrically conductive hydrogels by in situ reduction of poly(acrylic acid) grafted graphene oxide in polyacrylamide hydrogel matrix

2019 ◽  
Vol 137 (23) ◽  
pp. 48781
Author(s):  
Bengang Li ◽  
Chao Wu ◽  
Chengyu Wang ◽  
Zhenyang Luo ◽  
Jianpeng Cao
Keyword(s):  
Graphene Oxide ◽  
Acrylic Acid ◽  
Polyacrylamide Hydrogel ◽  
In Situ Reduction ◽  
Electrically Conductive ◽  
Hydrogel Matrix ◽  
Conductive Hydrogels ◽  
Poly Acrylic Acid

Physicochemical properties of geopolymer composites with DFT calculations of in-situ reduction of graphene oxide

2021 ◽  
Author(s):  
Amun Amri ◽  
Ahmad Ainun Najib ◽  
Monita Olivia ◽  
Mohammednoor Altarawneh ◽  
Aman Syam ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Dft Calculations ◽  
Physicochemical Properties ◽  
In Situ Reduction ◽  
Geopolymer Composites

scholarly journals Graphene Oxide-Embedded Extracellular Matrix- Derived Hydrogel as a Multiresponsive Platform for 3D Bioprinting Applications

2021 ◽  
Vol 7 (3) ◽  
Author(s):  
Laura Rueda-Gensini ◽  
Julian A Serna ◽  
Javier Cifuentes ◽  
Juan C Cruz ◽  
Carolina Muñoz-Camargo
Keyword(s):  
Graphene Oxide ◽  
Mechanical Stability ◽  
Light Exposure ◽  
Structural Characteristics ◽  
Elastic Response ◽  
Cellular Interaction ◽  
3D Bioprinting ◽  
In Situ Reduction ◽  
Crosslinking Degree

Decellularized extracellular matrices (dECMs) have shown enormous potential for the biofabrication of tissues due to their biomimetic properties that promote enhanced cellular interaction and tissue regeneration. However, biofabrication schemes requiring electrostimulation pose an additional constraint due to the insulating properties of natural materials. Here, we propose a methacryloyl-modified decellularized small intestine submucosa (SISMA) hydrogel, embedded with graphene oxide (GO) nanosheets, for extrusion-based 3D bioprinting applications that require electrostimulation. Methacryloyl biochemicalmodification is performed to enhance the mechanical stability of dECM constructs by mediating photo-crosslinking reactions, and a multistep fabrication scheme is proposed to harness the bioactive and hydrophilic properties of GO and electroconductive properties of reduced GO. For this, GO was initially dispersed in SISMA hydrogels by exploiting its hydrophilicity and protein adsorption capabilities, and in situ reduction was subsequently performed to confer electroconductive abilities. SISMA-GO composite hydrogels were successfully prepared with enhanced structural characteristics, as shown by the higher crosslinking degree and increased elastic response upon blue-light exposure. Moreover, GO was homogeneously dispersed without affecting photocrosslinking reactions and hydrogel shear-thinning properties. Human adipose-derived mesenchymal stem cells were successfully bioprinted in SISMA-GO with high cell viability after 1 week and in situ reduction of GO during this period enhanced the electrical conductivity of these nanostructures. This work demonstrates the potential of SISMA-GO bioinks as bioactive and electroconductive scaffolds for electrostimulation applications in tissue engineering and regenerative medicine.

scholarly journals The Anomalous Influence of Polyelectrolyte Concentration on the Deposition and Nanostructure of Poly(ethyleneimine)/Poly(acrylic acid) Multilayers

Molecules ◽  
2019 ◽  
Vol 24 (11) ◽  
pp. 2141 ◽  
Author(s):  
Martin Müller
Keyword(s):  
Acrylic Acid ◽  
Attenuated Total Reflection ◽  
Silicon Substrates ◽  
Acid Base ◽  
Exponential Relationship ◽  
Individual Adsorption ◽  
The Individual ◽  
Poly Acrylic Acid

The deposition and nanostructure of polyelectrolyte (PEL) multilayers (PEMs) of branched poly(ethyleneimine)/poly(acrylic acid) (PEI/PAA) onto silicon substrates was studied in terms of the dependence of pH and the PEL concentration (cPEL) in the individual adsorption steps z. Both a commercial automatic dipping device and a homebuilt automatic stream coating device (flow cell) were used. Gravimetry, SFM, transmission (TRANS) and in situ attenuated total reflection (ATR) FTIR spectroscopy were used for the quantitative determination of the adsorbed amount, thickness, chemical composition and morphology of deposited PEMs, respectively. Firstly, the combination of pH = 10 for PEI and pH = 4 for PAA, where both PEL were predominantly in the neutral state, resulted in an extraordinarily high PEM deposition, while pH combinations, where one PEL component was charged, resulted in a significantly lower PEM deposition. This was attributed to both PEL conformation effects and acid/base interactions between basic PEI and acidic PAA. Secondly, for that pH combination an exponential relationship between PEM thickness and adsorption step z was found. Thirdly, based on the results of three independent methods, the course of the deposited amount of a PEM-10 (z = 10) versus cPEL in the range 0.001 to 0.015 M at pH = 10/4 was non-monotonous showing a pronounced maximum at cPEL = 0.005 M. Analogously, for cPEL = 0.005 M a maximum of roughness and structure size was found. Fourthly, related to that finding, in situ ATR-FTIR measurements gave evidence for the release of outermost located PEI upon PAA immersion (even step) and of outermost PAA upon PEI immersion (odd step) under formation of PEL complexes in solution. These studies help us to prepare PEL-based films with a defined thickness and morphology for interaction with biofluids in the biomedical and food fields.

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