scholarly journals Optimized production of a high‐performance hybrid biomaterial: biomineralized spider silk for bone tissue engineering

2019 ◽  
Vol 137 (22) ◽  
pp. 48739 ◽  
Author(s):  
Alessandra Dellaquila ◽  
Gabriele Greco ◽  
Elisabetta Campodoni ◽  
Mauro Mazzocchi ◽  
Barbara Mazzolai ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
High Performance ◽  
Spider Silk

scholarly journals Spider silk-bone sialoprotein fusion proteins for bone tissue engineering

Soft Matter ◽  
2011 ◽  
Vol 7 (10) ◽  
pp. 4964 ◽  
Author(s):  
Sílvia Gomes ◽  
Isabel B. Leonor ◽  
João F. Mano ◽  
Rui L. Reis ◽  
David L. Kaplan
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Fusion Proteins ◽  
Spider Silk ◽  
Bone Sialoprotein

scholarly journals High performance additive manufactured scaffolds for bone tissue engineering application

Soft Matter ◽  
2011 ◽  
Vol 7 (18) ◽  
pp. 8013 ◽  
Author(s):  
M. Tarik Arafat ◽  
Christopher X. F. Lam ◽  
Andrew K. Ekaputra ◽  
Siew Yee Wong ◽  
Chaobin He ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
High Performance ◽  
Engineering Application ◽  
Tissue Engineering Application ◽  
Bone Tissue Engineering Application

High-performance porous PLLA-based scaffolds for bone tissue engineering: Preparation, characterization, and in vitro and in vivo evaluation

Polymer ◽  
2019 ◽  
Vol 180 ◽  
pp. 121707 ◽  
Author(s):  
Jiajun Ju ◽  
Xiangfang Peng ◽  
Keqing Huang ◽  
Lengwan Li ◽  
Xianhu Liu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
High Performance ◽  
In Vivo Evaluation

scholarly journals Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering

Materials ◽  
2016 ◽  
Vol 9 (7) ◽  
pp. 560 ◽  
Author(s):  
John Hardy ◽  
Jose Torres-Rendon ◽  
Aldo Leal-Egaña ◽  
Andreas Walther ◽  
Helmut Schlaad ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Composite Materials ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Spider Silk ◽  
Silk Protein ◽  
Spider Silk Protein

Application of graphene oxide-based hydrogels in bone tissue engineering

2021 ◽  
Vol 16 ◽  
Author(s):  
Kuang Zhihui ◽  
Ni Licheng ◽  
Xu Jianxiang ◽  
Xiao Shining ◽  
Zhou Chenwei ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Mechanical Strength ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Defect ◽  
High Performance ◽  
Essential Role ◽  
Defect Healing ◽  
Bone Defect Healing

: This paper provides a review on the applications of some graphene oxide-based hydrogels in bone tissue engineering. Hydrogels used in bone tissue engineering usually require suitable biocompatibility, porosity, and mechanical strength. By adding GO, under the original hydrogel condition, the various indexes of the composite hydrogel can reach more suitable conditions for inducing bone defect healing. This article also introduces some high-performance graphene oxide-based hydrogels, which are likely to play an essential role in bone tissue engineering in the future.

High-Performance Hydroxyapatite Scaffolds for Bone Tissue Engineering Applications

2011 ◽  
Vol 9 (3) ◽  
pp. 507-516 ◽  
Author(s):  
Francesca Gervaso ◽  
Francesca Scalera ◽  
Sanosh Kunjalukkal Padmanabhan ◽  
Alessandro Sannino ◽  
Antonio Licciulli
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
High Performance ◽  
Engineering Applications

HYDROXYAPATITE, ALGINATE, AND CHITOSAN FOR BONE SCAFFOLDS: SPECTROSCOPY STUDY

2016 ◽  
Vol 19 (2) ◽  
pp. 93-100
Author(s):  
Lalita El Milla
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Functional Groups ◽  
Bone Growth ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Tissue Engineering Scaffolds ◽  
Hydroxyapatite Powder ◽  
Materials Used

Scaffolds is three dimensional structure that serves as a framework for bone growth. Natural materials are often used in synthesis of bone tissue engineering scaffolds with respect to compliance with the content of the human body. Among the materials used to make scafffold was hydroxyapatite, alginate and chitosan. Hydroxyapatite powder obtained by mixing phosphoric acid and calcium hydroxide, alginate powders extracted from brown algae and chitosan powder acetylated from crab. The purpose of this study was to examine the functional groups of hydroxyapatite, alginate and chitosan. The method used in this study was laboratory experimental using Fourier Transform Infrared (FTIR) spectroscopy for hydroxyapatite, alginate and chitosan powders. The results indicated the presence of functional groups PO43-, O-H and CO32- in hydroxyapatite. In alginate there were O-H, C=O, COOH and C-O-C functional groups, whereas in chitosan there were O-H, N-H, C=O, C-N, and C-O-C. It was concluded that the third material containing functional groups as found in humans that correspond to the scaffolds material in bone tissue engineering.

PLGA+HA/βTCP scaffold incorporating simvastatin: a promising biomaterial for bone tissue engineering

2020 ◽  
Author(s):  
Mariane Beatriz Sordi ◽  
Ariadne Cristiane Cabral da Cruz ◽  
Águedo Aragones ◽  
Mabel Mariela Rodríguez Cordeiro ◽  
Ricardo de Souza Magini
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Thermal Analyses ◽  
Chemical Properties ◽  
Biological Properties ◽  
Scanning Calorimetry ◽  
Evaporation Technique ◽  
Porosity Analysis ◽  
Biphasic Ceramic

The aim of this study was to synthesize, characterize, and evaluate degradation and biocompatibility of poly(lactic-co-glycolic acid) + hydroxyapatite / β-tricalcium phosphate (PLGA+HA/βTCP) scaffolds incorporating simvastatin (SIM) to verify if this biomaterial might be promising for bone tissue engineering. Samples were obtained by the solvent evaporation technique. Biphasic ceramic particles (70% HA, 30% βTCP) were added to PLGA in a ratio of 1:1. Samples with SIM received 1% (m:m) of this medication. Scaffolds were synthesized in a cylindric-shape and sterilized by ethylene oxide. For degradation analysis, samples were immersed in PBS at 37 °C under constant stirring for 7, 14, 21, and 28 days. Non-degraded samples were taken as reference. Mass variation, scanning electron microscopy, porosity analysis, Fourier transform infrared spectroscopy, differential scanning calorimetry, and thermogravimetry were performed to evaluate physico-chemical properties. Wettability and cytotoxicity tests were conducted to evaluate the biocompatibility. Microscopic images revealed the presence of macro, meso, and micropores in the polymer structure with HA/βTCP particles homogeneously dispersed. Chemical and thermal analyses presented very similar results for both PLGA+HA/βTCP and PLGA+HA/βTCP+SIM. The incorporation of simvastatin improved the hydrophilicity of scaffolds. Additionally, PLGA+HA/βTCP and PLGA+HA/βTCP+SIM scaffolds were biocompatible for osteoblasts and mesenchymal stem cells. In summary, PLGA+HA/βTCP scaffolds incorporating simvastatin presented adequate structural, chemical, thermal, and biological properties for bone tissue engineering.

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