Functionalizable composite nanoparticles as a dual magnetic resonance imaging/computed tomography contrast agent for medical imaging

2019 ◽  
Vol 136 (19) ◽  
pp. 47571 ◽  
Author(s):  
Patrick Illert ◽  
Björn Wängler ◽  
Carmen Wängler ◽  
Frank Zöllner ◽  
Tanja Uhrig ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Magnetic Resonance ◽  
Medical Imaging ◽  
Contrast Agent ◽  
Composite Nanoparticles ◽  
Resonance Imaging

scholarly journals Colloidally Stable P(DMA-AGME)-Ale-Coated Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ Nanoparticles as a Multimodal Contrast Agent for Down- and Upconversion Luminescence, Magnetic Resonance Imaging, and Computed Tomography

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 230
Author(s):  
Oleksandr Shapoval ◽  
Viktoriia Oleksa ◽  
Miroslav Šlouf ◽  
Volodymyr Lobaz ◽  
Olga Trhlíková ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Upconversion Luminescence ◽  
In Vitro Toxicity ◽  
Resonance Imaging ◽  
Medical Disorders ◽  
Wide Range ◽  
T1 And T2

Multimodal imaging, integrating several modalities including down- and up-conversion luminescence, T1- and T2(T2*)-weighted MRI, and CT contrasting in one system, is very promising for improved diagnosis of severe medical disorders. To reach the goal, it is necessary to develop suitable nanoparticles that are highly colloidally stable in biologically relevant media. Here, hydrophilic poly(N,N-dimethylacrylamide-N-acryloylglycine methyl ester)-alendronate-[P(DMA-AGME)-Ale]-coated Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ nanoparticles were synthesized by a coprecipitation method in ethylene glycol (EG) followed by coating with the polymer. The particles were tho-roughly characterized by a dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), X-ray energy dispersive spectroscopy (EDAX), selected area electron diffraction (SAED), elemental ana-lysis and fluorescence spectroscopy. Aqueous particle dispersions exhibited excellent colloidal stability in water and physiological buffers. In vitro toxicity assessments suggested no or only mild toxicity of the surface-engineered Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ particles in a wide range of concentrations. Internalization of the particles by several types of cells, including HeLa, HF, HepG2, and INS, was confirmed by a down- and up-conversion confocal microscopy. Newly developed particles thus proved to be an efficient contrast agent for fluorescence imaging, T1- and T2(T2*)-weighted magnetic resonance imaging (MRI), and computed tomography (CT).

scholarly journals Investigation of the potential of using TiO2 nanoparticles as a contrast agent in computed tomography and magnetic resonance imaging

2019 ◽  
Vol 10 (8) ◽  
pp. 3143-3148 ◽  
Author(s):  
Hiroaki Akasaka ◽  
Naritoshi Mukumoto ◽  
Masao Nakayama ◽  
Tianyuan Wang ◽  
Ryuichi Yada ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Tio2 Nanoparticles ◽  
Resonance Imaging

Multimodal Contrast Agent for Combined Computed Tomography and Magnetic Resonance Imaging Applications

2006 ◽  
Vol 41 (3) ◽  
pp. 339-348 ◽  
Author(s):  
Jinzi Zheng ◽  
Gregory Perkins ◽  
Anna Kirilova ◽  
Christine Allen ◽  
David A. Jaffray
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Resonance Imaging
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