Guanine oxidation signal enhancement in single strand DNA with polyacrylonitrile/polyaniline (PAN/PAni) hybrid nanofibers

2017 ◽  
Vol 135 (3) ◽  
pp. 45567 ◽  
Author(s):  
Ezginur Cam ◽  
Nilay Aladag Tanik ◽  
Idris Cerkez ◽  
Elif Demirkan ◽  
Yakup Aykut
Keyword(s):  
Signal Enhancement ◽  
Single Strand ◽  
Guanine Oxidation ◽  
Hybrid Nanofibers

Structures of Artificially Designed RNA Nanoarchitectures at Near-Atomic Resolution

2020 ◽  
Author(s):  
Di Liu ◽  
Yaming Shao ◽  
Joseph A. Piccirilli ◽  
Yossi Weizmann
Keyword(s):  
Nucleic Acid ◽  
High Resolution ◽  
Single Strand ◽  
Atomic Resolution ◽  
Rna Motifs ◽  
X Ray ◽  
Structural Details ◽  
Rna Motif

<p>Though advances in nanotechnology have enabled the construction of synthetic nucleic acid based nanoarchitectures with ever-increasing complexity for various applications, high-resolution structures are lacking due to the difficulty of obtaining good diffracting crystals. Here we report the design of RNA nanostructures based on homooligomerizable tiles from an RNA single-strand for X-ray determination. Three structures are solved to near-atomic resolution: a 2D parallelogram, an unexpectedly formed 3D nanobracelet, and a 3D nanocage. Structural details of their constituent motifs—such as kissing loops, branched kissing-loops and T-junctions—that resemble natural RNA motifs and resisted X-ray determination are revealed. This work unveils the largely unexplored potential of crystallography in gaining high-resolution feedback for nanostructure design and suggests a novel route to investigate RNA motif structures by configuring them into nanoarchitectures.</p>

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