Self-assembling amphiphilic PEGylated block copolymers obtained through RAFT polymerization for drug-delivery applications

2015 ◽  
Vol 133 (11) ◽  
pp. n/a-n/a ◽  
Author(s):  
Claudio Colombo ◽  
Simone Gatti ◽  
Raffaele Ferrari ◽  
Tommaso Casalini ◽  
Danilo Cuccato ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Raft Polymerization ◽  
Self Assembling ◽  
Drug Delivery Applications

scholarly journals Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5147
Author(s):  
Wanting Hou ◽  
Ruiqi Liu ◽  
Siwei Bi ◽  
Qian He ◽  
Haibo Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Delivery System ◽  
Delivery System ◽  
Raft Polymerization ◽  
Amphiphilic Block Copolymers ◽  
Medical Applications ◽  
Drug Molecules ◽  
Reversible Addition ◽  
Raft Agent

Due to a strong retardation effect of o-nitrobenzyl ester on polymerization, it is still a great challenge to prepare amphiphilic block copolymers for polymersomes with a o-nitrobenzyl ester-based hydrophobic block. Herein, we present one such solution to prepare amphiphilic block copolymers with pure poly (o-nitrobenzyl acrylate) (PNBA) as the hydrophobic block and poly (N,N’-dimethylacrylamide) (PDMA) as the hydrophilic block using bulk reversible addition-fragmentation chain transfer (RAFT) polymerization of o-nitrobenzyl acrylate using a PDMA macro-RAFT agent. The developed amphiphilic block copolymers have a suitable hydrophobic/hydrophilic ratio and can self-assemble into photoresponsive polymersomes for co-loading hydrophobic and hydrophilic cargos into hydrophobic membranes and aqueous compartments of the polymersomes. The polymersomes demonstrate a clear photo-responsive characteristic. Exposure to light irradiation at 365 nm can trigger a photocleavage reaction of o-nitrobenzyl groups, which results in dissociation of the polymersomes with simultaneous co-release of hydrophilic and hydrophobic cargoes on demand. Therefore, these polymersomes have great potential as a smart drug delivery nanocarrier for controllable loading and releasing of hydrophilic and hydrophobic drug molecules. Moreover, taking advantage of the conditional releasing of hydrophilic and hydrophobic drugs, the drug delivery system has potential use in medical applications such as cancer therapy.

scholarly journals Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

Polymers ◽  
2011 ◽  
Vol 3 (2) ◽  
pp. 779-811 ◽  
Author(s):  
Giulia Bonacucina ◽  
Marco Cespi ◽  
Giovanna Mencarelli ◽  
Gianfabio Giorgioni ◽  
Giovanni Filippo Palmieri
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Self Assembling

Synthesis of Functional Core, Star Polymers via RAFT Polymerization for Drug Delivery Applications

2012 ◽  
Vol 33 (9) ◽  
pp. 760-766 ◽  
Author(s):  
Jinna Liu ◽  
Hien Duong ◽  
Michael R. Whittaker ◽  
Thomas P. Davis ◽  
Cyrille Boyer
Keyword(s):  
Drug Delivery ◽  
Raft Polymerization ◽  
Star Polymers ◽  
Drug Delivery Applications

Star-Shaped Block Copolymers by Copper-Catalyzed Azide-Alkyne Cycloaddition for Potential Drug Delivery Applications

2012 ◽  
Vol 213 (20) ◽  
pp. 2146-2156 ◽  
Author(s):  
Christian von der Ehe ◽  
Kristian Kempe ◽  
Marius Bauer ◽  
Anja Baumgaertel ◽  
Martin D. Hager ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Potential Drug ◽  
Drug Delivery Applications

Synthesis of click-reactive HPMA copolymers using RAFT polymerization for drug delivery applications

2013 ◽  
Vol 51 (23) ◽  
pp. 5091-5099 ◽  
Author(s):  
Morten F. Ebbesen ◽  
David H. Schaffert ◽  
Michael L. Crowley ◽  
David Oupický ◽  
Kenneth A. Howard
Keyword(s):  
Drug Delivery ◽  
Raft Polymerization ◽  
Hpma Copolymers ◽  
Drug Delivery Applications
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