Dextrin crosslinked with poly(lactic acid): A novel hydrogel for controlled drug release application

2013 ◽  
Vol 131 (7) ◽  
pp. n/a-n/a ◽  
Author(s):  
Dipankar Das ◽  
Raghunath Das ◽  
Jayanta Mandal ◽  
Animesh Ghosh ◽  
Sagar Pal
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Poly Lactic Acid

scholarly journals Amorphous binary dispersions of chloramphenicol in enantiomeric pure and racemic poly-lactic acid: Morphology, molecular relaxations, and controlled drug release

2019 ◽  
Vol 568 ◽  
pp. 118565 ◽  
Author(s):  
Sofia Valenti ◽  
Angelica Diaz ◽  
Michela Romanini ◽  
Luis Javier del Valle ◽  
Jordi Puiggalí ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Poly Lactic Acid

Controlled drug release through regulated biodegradation of poly(lactic acid) using inorganic salts

2017 ◽  
Vol 104 ◽  
pp. 487-497 ◽  
Author(s):  
Sunil Kumar ◽  
Shikha Singh ◽  
Sudipta Senapati ◽  
Akhand Pratap Singh ◽  
Biswajit Ray ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Inorganic Salts ◽  
Poly Lactic Acid

Facile synthesis of amphiphilic chitosan-g-poly(lactic acid) derivatives and the study of their controlled drug release

2013 ◽  
Vol 130 (2) ◽  
pp. 908-915 ◽  
Author(s):  
Hong-Wei Lu ◽  
Hong He ◽  
Bin Zhang ◽  
Guo-Qiang Liu ◽  
Meng-Yao Li ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Poly Lactic Acid ◽  
Facile Synthesis

scholarly journals Drug Release from Electrospun Poly(Lactic Acid) Membranes and Their Cell Viability in Vitro Test

2012 ◽  
Vol 44 ◽  
pp. 866-868 ◽  
Author(s):  
A.P.S. Immich ◽  
M. Lis ◽  
L.H. Catalani ◽  
R.L. Boemo ◽  
J.A. Tornero
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Cell Viability ◽  
Poly Lactic Acid ◽  
In Vitro Test ◽  
Vitro Test

scholarly journals Preparation and Drug-Release Kinetics of Porous Poly(L-lactic acid)/Rifampicin Blend Particles

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Takashi Sasaki ◽  
Hiroaki Matsuura ◽  
Kazuki Tanaka
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Solution Concentration ◽  
Porous Polymer ◽  
High Porosity ◽  
Original Solution ◽  
Kinetics Of

Porous polymer spheres are promising materials as carriers for controlled drug release. As a new drug-carrier material, blend particles composed of poly(L-lactic acid) (PLLA) and rifampicin were developed using the freeze-drying technique. The blend particles exhibit high porosity with a specific surface area of 10–40 m2 g−1. Both the size and porosity of the particles depend on the concentration of the original solution and on the method of freezing. With respect to the latter, we used the drop method (pouring the original solution dropwise into liquid nitrogen) and the spray method (freezing a mist of the original solution). The release kinetics of rifampicin from the blend particles into water depends significantly on the morphology of the blend particles. The results show that the release rate can be controlled to a great extent by tuning the size and porosity of the blend particles, both of which are varied by parameters such as the solution concentration and the method of freezing.

Synthesis and Kinetic Studies on Controlled Release of 6-Thioguanine Entrapped Polyethylene Glycol-Co-Polylactic Acid Polymer Nanoparticles

2011 ◽  
Vol 9 (1) ◽  
Author(s):  
Sathishkumar Kannaiyan ◽  
T.G.Ashwin Narayanan ◽  
P.Karthick Sarathy ◽  
Nagarjun Sudhakar ◽  
Rama Krishnan
Keyword(s):  
Gold Nanoparticles ◽  
Lactic Acid ◽  
Polyethylene Glycol ◽  
Controlled Release ◽  
Drug Release ◽  
Kinetic Equations ◽  
Kinetic Studies ◽  
Poly Lactic Acid ◽  
Average Size

Poly lactic acid-polyethylene glycol (PLA-co-PEG) copolyester was synthesized from oligomer of L-lactic acid and poly ethylene glycol (PEG) using stannous octoate as catalyst. 6-Thioguanine containing Poly lactic acid-polyethylene glycol (PLA-co-PEG) nanocapsules were prepared in the presence and absence of gold nanoparticles via the W/O/W emulsification solvent-evaporation method. The morphologies of prepared nanocapsules changed substantially because of the presence of gold nanoparticles. From SEM and TEM measurements, the average size of the polymer nanocapsules and gold nanoparticles were found to be in range of 230-260 nm and 18-20 nm, respectively. In general the drug release was quicker in Phosphate buffer saline (pH 7.4) compared to 0.1M hydrochloric acid and this may be due to higher solubility, higher swelling and penetration properties of PLA-co-PEG in PBS compared to HCl. Polymer nanocapsules with gold show a prolonged controlled release with higher encapsulation efficiency (75%) compared to that of polymer nanocapsules (45%) in the absence of gold nanoparticles. It may be due to the more entrapping efficiency of gold and less diffusivity of drugs from the nanocapsules. Application of in vitro drug release data to various kinetic equations indicated Higuchi model, indicating a uniform distribution of thioguanine in the nanocapsules.

Degradation of and drug release from a novel 2,2-bis(2-oxazoline) linked poly(lactic acid) polymer

2002 ◽  
Vol 81 (3) ◽  
pp. 251-261 ◽  
Author(s):  
Tommy Tarvainen ◽  
Teija Karjalainen ◽  
Minna Malin ◽  
Satu Pohjolainen ◽  
Jukka Tuominen ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Poly Lactic Acid

Assessment of structural, biological and drug release properties of electro-sprayed poly lactic acid-dexamethasone coating for biomedical applications

2021 ◽  
Vol 11 (4) ◽  
pp. 393-406
Author(s):  
Mostafa Rahvar ◽  
Gholamreza Ahmadi Lakalayeh ◽  
Niloofar Nazeri ◽  
Bahereh T. Marouf ◽  
Mahdieh Shirzad ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Biomedical Applications ◽  
Poly Lactic Acid
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