Permeability and blood compatibility of nanoporous parylene film-coated polyethersulfone membrane under long-term blood diffusion

2013 ◽  
Vol 131 (6) ◽  
pp. n/a-n/a ◽  
Author(s):  
Gunawan Setia Prihandana ◽  
Hikaru Ito ◽  
Ippei Sanada ◽  
Yuya Nishinaka ◽  
Yoshihiko Kanno ◽  
...  
Keyword(s):  
Blood Compatibility ◽  
Polyethersulfone Membrane ◽  
Parylene Film

scholarly journals Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review

2021 ◽  
Vol 8 (12) ◽  
pp. 215
Author(s):  
Janna Kuchinka ◽  
Christian Willems ◽  
Dmitry V. Telyshev ◽  
Thomas Groth
Keyword(s):  
Blood Coagulation ◽  
Medical Devices ◽  
Heart Valves ◽  
Blood Compatibility ◽  
Blood Platelets ◽  
Bleeding Risk ◽  
Ventricular Assist Devices ◽  
Coagulation System ◽  
Material Surfaces

Hemocompatibility of biomaterials in contact with the blood of patients is a prerequisite for the short- and long-term applications of medical devices such as cardiovascular stents, artificial heart valves, ventricular assist devices, catheters, blood linings and extracorporeal devices such as artificial kidneys (hemodialysis), extracorporeal membrane oxygenation (ECMO) and cardiopulmonary bypass. Although lower blood compatibility of materials and devices can be handled with systemic anticoagulation, its side effects, such as an increased bleeding risk, make materials that have a better hemocompatibility highly desirable, particularly in long-term applications. This review provides a short overview on the basic mechanisms of blood coagulation including plasmatic coagulation and blood platelets, as well as the activation of the complement system. Furthermore, a survey on concepts for tailoring the blood response of biomaterials to improve the hemocompatibility of medical devices is given which covers different approaches that either inhibit interaction of material surfaces with blood components completely or control the response of the coagulation system, blood platelets and leukocytes.

Improved blood compatibility of polyethersulfone membrane with a hydrophilic and anionic surface

2012 ◽  
Vol 100 ◽  
pp. 116-125 ◽  
Author(s):  
Shengqiang Nie ◽  
Jimin Xue ◽  
Yi Lu ◽  
Yeqiu Liu ◽  
Dongsheng Wang ◽  
...  
Keyword(s):  
Blood Compatibility ◽  
Polyethersulfone Membrane ◽  
Anionic Surface

Synthesis of a novel biomedical poly(ester urethane) based on aliphatic uniform-size diisocyanate and the blood compatibility of PEG-grafted surfaces

2018 ◽  
Vol 32 (10) ◽  
pp. 1329-1342 ◽  
Author(s):  
Xiaolong Liu ◽  
Yiran Xia ◽  
Lulu Liu ◽  
Dongmei Zhang ◽  
Zhaosheng Hou
Keyword(s):  
Mechanical Properties ◽  
Platelet Adhesion ◽  
Blood Compatibility ◽  
Chain Extension ◽  
Soft Tissue Augmentation ◽  
Resonance Spectroscopy ◽  
Scanning Calorimetry ◽  
Uniform Size ◽  
Chemical Structures

The purpose of this study is to offer a novel kind of polyurethane with improved surface blood compatibility for long-term implant biomaterials. In this work, the aliphatic poly(ester-urethane) (PEU) with uniform-size hard segments was prepared and the PEU surface was grafted with hydrophilic poly(ethylene glycol) (PEG). The PEU was obtained by chain-extension of poly(ɛ-caprolactone) (PCL) with isocyanate-terminated urethane triblock. Free amino groups were introduced onto the surface of PEU film via aminolysis with hexamethylenediamine, and then the NH2-grafted PEU surfaces (PEU-NH2) were reacted with isocyanate-terminated monomethoxyl PEG (MPEG-NCO) to obtain the PEG-grafted PEU surfaces (PEU-PEG). Analysis by nuclear magnetic resonance spectroscopy, Fourier transform infrared spectroscopy, and gel permeation chromatography were performed to confirm the chemical structures of the chain extender, PCL, PEU, and PEU-PEG. Additionally, the influence of aminolysis on the physical-mechanical properties of PEU films was investigated. Two glass transition temperatures and a broad endothermic peak were observed in the differential scanning calorimetry curves of PEU, which demonstrated a microphase-separated and semicrystalline structure, respectively. The PEU-PEG film exhibited excellent mechanical properties with an ultimate stress of ∼39 MPa and an elongation at break of ∼1190%, which was slightly lower than that of PEU, indicating that the aminolysis has little influence on the tensile properties. Evaluation of the blood compatibility of the films by bovine serum albumin adsorption and the platelet adhesion test revealed that the PEG-grafted surface had improved resistance to protein adsorption and excellent resistance to platelet adhesion. In vitro degradation tests showed that the PEU-PEG film could maintain its mechanical properties for more than six months and only lost ∼25% weight after 18 months. Due to the excellent mechanical properties, good blood compatibility and slow degradability, this novel kind of polyurethane hold significant promise for long-term implant biomaterials, especially soft tissue augmentation and regeneration.

Construction of novel antiplatelet modified polyethersulfone membrane and study into its blood compatibility

2022 ◽  
pp. 112659
Author(s):  
Xiao Fu ◽  
Ting Lei ◽  
Shu-jun Li ◽  
Yan-feng Liu ◽  
Jie Peng ◽  
...  
Keyword(s):  
Blood Compatibility ◽  
Polyethersulfone Membrane

scholarly journals Numerical Simulation of LVAD Inflow Cannulas with Different Tip

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Guang-Mao Liu ◽  
Hai-Bo Chen ◽  
Fu-Liang Luo ◽  
Yan Zhang ◽  
Han-Song Sun ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Left Ventricle ◽  
Blood Compatibility ◽  
Flow Behavior ◽  
Low Velocity ◽  
Smooth Flow ◽  
Velocity Flow ◽  
Inflow Cannula ◽  
Major Factors

The tip structure of LVAD inflow cannula is one of major factors to lead adverse events such as thrombosis and suction leading to obstruction. In this research, four kinds of tips that had been used in inflow cannulas were selected and designed. The flow field of the four inflow cannulas inserted into the apex of left ventricle (LV) was numerically computed by computational fluid dynamics. The flow behavior was analyzed in order to compare the blood compatibility and suction in left ventricle and cannulas after the inflow cannulas with different tips were inserted to the apex of LV. The results showed that the cannula tip structure affected the LVAD performance. Among these four cannulas, the trumpet-tipped inflow cannula owned the best performance in smooth flow velocity distribution without backflow or low-velocity flow so that it was the best in blood compatibility. Nevertheless, the caged tipped cannula was the worst in blood compatibility. And the blunt-tipped and beveled tipped inflow cannulas may obstruct more easily than trumpet and caged tipped inflow cannulas because of their shape. The study indicated that the trumpet tip was the most preferable for the inflow cannula of long-term LVAD.

Blood compatibility of polyethersulfone membrane by blending a sulfated derivative of chitosan

2013 ◽  
Vol 95 (1) ◽  
pp. 64-71 ◽  
Author(s):  
Jimin Xue ◽  
Weifeng Zhao ◽  
Shengqiang Nie ◽  
Shudong Sun ◽  
Changsheng Zhao
Keyword(s):  
Blood Compatibility ◽  
Polyethersulfone Membrane ◽  
Sulfated Derivative
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