Study on poly(D,L-lactic) microspheres embedded in calcium alginate hydrogel beads as dual drug delivery systems

2012 ◽  
Vol 129 (2) ◽  
pp. 767-772 ◽  
Author(s):  
Dagen Zhong ◽  
Zonghua Liu ◽  
Shasha Xie ◽  
Wei Zhang ◽  
Yuanming Zhang ◽  
...  
2019 ◽  
Vol 7 (3) ◽  
pp. 103134 ◽  
Author(s):  
Sudeshna Saha ◽  
Manisha Venkatesh ◽  
Hirakendu Basu ◽  
Mehzabin Vivek Pimple ◽  
Rakesh Kumar Singhal

2016 ◽  
Vol 104 (12) ◽  
Author(s):  
Kangkana Sarkar ◽  
Susanta Lahiri ◽  
Kamalika Sen

AbstractPb is a promising radioisotope in the field of medical science as an imaging surrogate of


2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Brent Lanting ◽  
Joe Barfett

A calcium carbonate suspension, encapsulated within particles of calcium alginate hydrogel, is proposed as a drug delivery device susceptible to ultrasound disruption. Spheres approximately 1mm in diameter were prepared by the coaxial airflow method from mixtures of 1% sodium alginate (m/v) and each of 50%, 75% and 100% calcium carbonate (m/v) in distilled water. This product was subjected to cycles of 85 Watt ultrasound in 1 second on/off bursts via a lab sonication system until fully disintegrated, a process requiring between 8 and 20 minutes depending upon initial calcium carbonate concentrations. The spheres subjected to vortex did not demonstrate any signs of mechanical degeneration after 30 minutes. Before use as a model implant, further work is required to develop a method of drying the particles to make them impermeable to drug diffusion before the time of their disruption with ultrasound.


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