Microencapsulation of nanoparticles with enhanced drug loading for pH-sensitive oral drug delivery for the treatment of colon cancer

2012 ◽  
Vol 129 (2) ◽  
pp. 714-720 ◽  
Author(s):  
Yichao Wang ◽  
Puwang Li ◽  
Zheng Peng ◽  
Feng Hua She ◽  
Ling Xue Kong
Keyword(s):  
Drug Delivery ◽  
Colon Cancer ◽  
Oral Drug Delivery ◽  
Drug Loading ◽  
Ph Sensitive ◽  
Oral Drug

scholarly journals Development of Polymeric Nanoparticles ofGarcinia mangostanaXanthones in Eudragit RL100/RS100 for Anti-Colon Cancer Drug Delivery

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Abdalrahim F. A. Aisha ◽  
Amin Malik Shah Abdulmajid ◽  
Zhari Ismail ◽  
Salman A. Alrokayan ◽  
Khalid M. Abu-Salah
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Colon Cancer ◽  
Oral Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Drug Loading ◽  
Intracellular Delivery ◽  
Oral Drug ◽  
Cancer Drug ◽  
Freeze Dried

Xanthones are a group of oxygenated heterocyclic compounds with anticancer properties, but poor aqueous solubility and low oral bioavailability hinder their therapeutic application. This study sought to prepare a xanthones extract (81%  α-mangostin and 16%  γ-mangostin) in polymeric nanoparticles and to investigate its intracellular delivery and cytotoxicity toward colon cancer cells. The nanoparticles were prepared in Eudragit RL100 and Eudragit RS100 by the nanoprecipitation method at drug loading and entrapment efficiency of 20% and >95%, respectively. Freeze-drying of bulk nanoparticle solutions, using glucose or sucrose as cryoprotectants, allowed the collection of nanoparticles at >95% yield. Solubility of the xanthones extract was improved from 0.1 µg/mL to 1250 µg/mL. Transmission electron microscopy (TEM) and dynamic light scattering (DLS) of the freeze-dried final formulation showed the presence of cationic round nanoparticles, with particle size in the range of 32–130 nm. Scanning electron microscopy (SEM) showed the presence of nanospheres, and Fourier transform infrared (FTIR) spectroscopy indicated intermolecular interaction of xanthones with Eudragit polymers. Cellular uptake of nanoparticles was mediated via endocytosis and indicated intracellular delivery of xanthones associated with potent cytotoxicity (median inhibitory concentration26.3±0.22 µg/mL). Presented results suggest that cationic nanoparticles of xanthones may provide a novel oral drug delivery system for chemoprevention or treatment of intestinal and colon tumors.

Investigation of pH-sensitive galactopyranoside glycol hydrogels as effective vehicles for oral drug delivery

2014 ◽  
Vol 21 (4) ◽  
Author(s):  
Solmaz Zakhireh ◽  
Mehrdad Mahkam ◽  
Mehdi Yadollahi ◽  
Saeed Jafarirad
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Ph Sensitive ◽  
Oral Drug
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