Thermally induced crystallization and enzymatic degradation studies of poly (L-lactic acid) films

2012 ◽  
Vol 127 (6) ◽  
pp. 4395-4401 ◽  
Author(s):  
Nadarajah Vasanthan ◽  
Hande Gezer
Keyword(s):  
Lactic Acid ◽  
Enzymatic Degradation ◽  
Thermally Induced ◽  
Degradation Studies ◽  
Induced Crystallization

scholarly journals Vapor-induced Crystallization in Alcoholic Sorption using Poly(lactic acid) Films

2018 ◽  
Vol 22 (2) ◽  
Author(s):  
Y. Moriizumi ◽  
K. Nagai
Keyword(s):  
Lactic Acid ◽  
Cluster Size ◽  
Poly Lactic Acid ◽  
Molecular Volume ◽  
High Increase ◽  
Thermally Induced ◽  
Alcohol Vapor ◽  
Pressure Region ◽  
High Pressure Region ◽  
Induced Crystallization

In this study, the sorption amount of alcohols (ethanol, 1-propanol, and 2-propanol) vapors on poly(lactic acid) (PLA) membrane was measured resulting in high increase in sorption. Sorption amount increases as the molecular volume of vapor decreases in the low-pressure region. The sorption amount of branched 2-propanol is lower than that of linear 1-propanol. In the high-pressure region, the PLA film tends to swell or plasticize as the cluster size increases, thereby increasing sorption. In addition, the alcohol vapor sorbed in the PLA film causes vapor-induced crystallization, which is in contrast to solvent- and thermally-induced crystallization, and forms an unknown crystal structure.

Enzymatic Degradation of Poly(l-Lactic Acid): Effects of UV Irradiation

2006 ◽  
Vol 14 (3) ◽  
pp. 239-248 ◽  
Author(s):  
Hideto Tsuji ◽  
Yoshihisa Echizen ◽  
Yoshiro Nishimura
Keyword(s):  
Lactic Acid ◽  
Uv Irradiation ◽  
Enzymatic Degradation

The influence of Fe3+ doping on thermally induced crystallization and phase evolution of amorphous calcium phosphate

CrystEngComm ◽  
2021 ◽  
Author(s):  
Diana Griesiute ◽  
Lauryna Sinusaite ◽  
Agne Kizalaite ◽  
Andris Antuzevics ◽  
Kestutis Mazeika ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Phase Evolution ◽  
Thermally Induced ◽  
Induced Crystallization

The present study investigates thermally induced crystallization and phase evolution of amorphous calcium phosphate (ACP) partially substituted with Fe3+ ions (M/P = 1.5 : 1). It was demonstrated that the...

Structure–property relation of porous poly (l-lactic acid) scaffolds fabricated using organic solvent mixtures and controlled cooling rates and its bio-compatibility with human adipose stem cells

2018 ◽  
Vol 33 (4) ◽  
pp. 397-415 ◽  
Author(s):  
Harish Chinnasami ◽  
Jeff Gimble ◽  
Ram V Devireddy
Keyword(s):  
Stem Cells ◽  
Cell Proliferation ◽  
Lactic Acid ◽  
Phase Separation ◽  
Mechanical Strength ◽  
Separation Method ◽  
Thermally Induced Phase Separation ◽  
Cooling Rates ◽  
Thermally Induced ◽  
Pore Sizes

Thermally induced phase separation method was used to make porous three-dimensional poly (l-lactic acid) scaffolds. The effect of imposed thermal profile during freezing of the poly (l-lactic acid) in dioxane solution on the scaffold was characterized by their micro-structure, porosity (%), pore sizes’ distribution, and mechanical strength. The porosity (%) decreased considerably with increasing concentrations of poly (l-lactic acid) in the solution, while a decreasing trend was observed with increasing cooling rates. The mechanical strength increases with increase in poly (l-lactic acid) concentration and also with increase in the cooling rate for both types of solvents. Therefore, mechanical strength was increased by higher cooling rates while the porosity (%) remained relatively consistent. Scaffolds made using higher concentrations of poly (l-lactic acid; 7% and 10% w/v) in solvent showed better mechanical strength which improved relatively with increasing cooling rates (1°C–40°C/min). This phenomenon of enhanced structural integrity with increasing cooling rates was more prominent in scaffolds made from higher initial poly (l-lactic acid) concentrations. Human adipose–derived stem cells were cultured on these scaffold (7% and 10% w/v) prepared by thermally induced phase separation at all cooling rates to measure the cell proliferation efficiency as a function of their micro-structural properties. Mean pore sizes played a crucial role in cell proliferation than percent porosity since all scaffolds were >88% porous. The viability percent of human adipose tissue–derived adult stem cells increased consistently with longer periods of culture. Thus, poly (l-lactic acid) scaffolds prepared by thermally controlled thermally induced phase separation method could be a prime candidate for making ex vivo tissue-engineered grafts for surgical implantation.

Preparation of levodopa-loaded crystalsomes through thermally induced crystallization reverses functional deficits in Parkinsonian mice

2019 ◽  
Vol 7 (4) ◽  
pp. 1623-1631 ◽  
Author(s):  
Xinyu Li ◽  
Qianqian Liu ◽  
Dashuai Zhu ◽  
Yongzhe Che ◽  
Xizeng Feng
Keyword(s):  
Pathological Features ◽  
Thermally Induced ◽  
Functional Deficits ◽  
Behavioral Impairments ◽  
Induced Crystallization

The prepared levodopa loaded crystalsomes are nanoscale crystals and controlling levodopa release which improving MPTP-induced behavioral impairments and pathological features of mice.

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