Surface modification of contact lenses using adsorption of ethylene oxide branched copolymers

2012 ◽  
Vol 127 (5) ◽  
pp. 3657-3662 ◽  
Author(s):  
Ikuko Toki ◽  
Masanori Komatsu ◽  
Yoshio Shimizu ◽  
Yusuke Hara
2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Zahida Ademović ◽  
Snježana Marić ◽  
Peter Kingshott ◽  
Zoran Iličković

Contact lenses suffer from two limitations: low oxygen permeability and deposition of protein and lipids. In order to prevent bioadhesion, surface must be completely inert to all biological reactions. To achieve this, surface properties must be tailored. Also, to improve comfort, surface must be highly wettable and lubricous. In this paper the surface of silicone contact lenses was modified by plasma induced copolymerization of acrylic acid. A wettable surface was generated and in addition carboxyl groups that were created on the surface provided an ideal reactive platform for subsequent grafting of polyethylene glycol. Each surface modification step was analysed by XPS and contact angle measurements. Lysozyme adsorption on modified silicone contact lenses was analysed by surface-MALDI-ToF-MS and XPS. After incubation with lysozyme, surface-MALDI-TOF-MS and XPS analysis showed a reduction of adsorbed lysozyme on hydrogel modified contact lenses. Surface modification of silicone with PEG is a method for reduction of protein adsorption on contact lenses.


1989 ◽  
Vol 12 (6) ◽  
pp. 390-394 ◽  
Author(s):  
E. Brinkman ◽  
A. Poot ◽  
T. Beugeling ◽  
L. Van Der Does ◽  
A. Bantjes

Pellethane 2363 80A catheters were modified with poly(ethylene oxide) in order to improve their blood compatibility. Contact angle measurements showed that Pellethane 2363 80A surfaces had increased wettability after this modification. The results of in vitro blood compatibility tests showed that surface modification with poly(ethylene oxide) resulted in a five-fold reduction of platelet deposition. Activation of coagulation was not affected.


2018 ◽  
Vol 296 (4) ◽  
pp. 637-645 ◽  
Author(s):  
Brandon T. DiTullio ◽  
Cassandra J. Wright ◽  
Patricia Hayes ◽  
Paul J. Molino ◽  
Timothy W. Hanks

2013 ◽  
Vol 36 ◽  
pp. e26-e27
Author(s):  
Christopher Loose ◽  
Alonzo Cook ◽  
Jun Li ◽  
Matthew Skinner ◽  
Zheng Zhang

2018 ◽  
Vol 20 (6) ◽  
pp. 1700963
Author(s):  
Yousef Alqurashi ◽  
Magdalena Bajgrowicz-Cieslak ◽  
Muhammad Umair Hassan ◽  
Ali K. Yetisen ◽  
Haider Butt

2008 ◽  
Vol 19 (12) ◽  
pp. 125306 ◽  
Author(s):  
Frédéric Brétagnol ◽  
Lucel Sirghi ◽  
Stéphane Mornet ◽  
Takao Sasaki ◽  
Douglas Gilliland ◽  
...  

2012 ◽  
Vol 35 ◽  
pp. e9
Author(s):  
Alonzo D. Cook ◽  
Jun Li ◽  
Matt Skinner ◽  
Karen Schultz ◽  
Chris Loose ◽  
...  

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