Water-soluble star polymers with a phthalocyanine as the core and poly(ethylene glycol) chains as branches

2012 ◽  
Vol 126 (4) ◽  
pp. 1359-1368 ◽  
Author(s):  
Placido Mineo ◽  
Rossana Alicata ◽  
Norberto Micali ◽  
Valentina Villari ◽  
Emilio Scamporrino
Keyword(s):  
Ethylene Glycol ◽  
Star Polymers ◽  
Water Soluble ◽  
Poly Ethylene Glycol ◽  
The Core ◽  
Poly Ethylene

scholarly journals Drug Carriers With Star Polymer Structures

2018 ◽  
pp. S293-S303 ◽  
Author(s):  
L. KOTRCHOVÁ ◽  
L. KOSTKA ◽  
T. ETRYCH
Keyword(s):  
Ethylene Glycol ◽  
Drug Carriers ◽  
Water Soluble ◽  
Star Polymer ◽  
Poly Ethylene Glycol ◽  
The Core ◽  
Polyamidoamine Dendrimers ◽  
Hydroxypropyl Methacrylamide ◽  
Poly Ethylene ◽  
Synthetic Approaches

In this review we summarize several synthetic approaches to the advanced synthesis of star-like polymer-based drug carriers. Moreover, their application as nanomedicines for therapy or the diagnosis of neoplastic diseases and their biodistribution are reviewed in detail. From a broad spectrum of star-like systems, we focus only on fully water-soluble systems, mainly based on poly(ethylene glycol) or N-(2-hydroxypropyl)methacrylamide polymer and copolymer arms and polyamidoamine dendrimers serving as the core of the star-like systems.

Peptide-Based Star Polymers as Potential siRNA Carriers

2014 ◽  
Vol 67 (4) ◽  
pp. 592 ◽  
Author(s):  
Shu Jie Lam ◽  
Adrian Sulistio ◽  
Katharina Ladewig ◽  
Edgar H. H. Wong ◽  
Anton Blencowe ◽  
...  
Keyword(s):  
Ring Opening ◽  
Star Polymers ◽  
Pamam Dendrimers ◽  
Water Soluble ◽  
Poly Ethylene Glycol ◽  
The Core ◽  
Poly Ethylene ◽  
Interfering Rna ◽  
Carbodiimide Coupling

16- and 32-arm star polymers were synthesised using poly(amido amine) (PAMAM) dendrimers as multifunctional initiators for the ring-opening polymerisation (ROP) of ϵ-Z-l-lysine N-carboxyanhydride (Lys NCA) via the core-first approach. The resulting star polymers were subsequently post-functionalised with poly(ethylene glycol) (PEG) via carbodiimide coupling, potentially improving the biodistribution of the stars in vivo. De-protection of the carboxybenzyl (Cbz)-protected star arms yielded water-soluble cationic poly(l-lysine) (PLL) star polymers with hydrodynamic radii ranging from 2.0 to 3.3 nm. Successful complexation of the PLL star polymers with double-stranded oligodeoxynucleotides (ODNs)—a mimic for small interfering RNA (siRNA)—was achieved at a nitrogen-to-phosphate (N/P) ratio of 5. Cell viability studies using HEK293T cells indicated the ‘safe’ concentration for these polymers is within a suitable window for the delivery of siRNA therapeutics.

Water-soluble polyesters from long chain alkylesters of citric acid and poly(ethylene glycol)

2007 ◽  
Vol 43 (4) ◽  
pp. 1288-1301 ◽  
Author(s):  
Fabienne Barroso-Bujans ◽  
Ricardo Martínez ◽  
Mehrdad Yazdani-Pedram ◽  
Pedro Ortiz ◽  
Holger Frey
Keyword(s):  
Citric Acid ◽  
Ethylene Glycol ◽  
Water Soluble ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Long Chain
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