Synthesis and properties of biodegradable network poly(ether-urethane)s fromL-lysine triisocyanate and poly(alkylene glycol)s

2012 ◽  
Vol 126 (S2) ◽  
pp. E358-E364 ◽  
Author(s):  
Minoru Nagata ◽  
Akito Oi ◽  
Wataru Sakai ◽  
Naoto Tsutsumi
Keyword(s):  
Alkylene Glycol

scholarly journals Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid

2007 ◽  
Vol 61 (2) ◽  
pp. 83-89
Author(s):  
Maja Micic ◽  
Simonida Tomic ◽  
Jovanka Filipovic ◽  
Edin Suljovrujic
Keyword(s):  
Itaconic Acid ◽  
Biological Fluids ◽  
Radical Copolymerization ◽  
Hydroxyethyl Methacrylate ◽  
Ethanol Mixture ◽  
Good Biocompatibility ◽  
Poly Ethylene ◽  
Ph Range ◽  
Alkylene Glycol ◽  
Sensitive Behavior

New types of hydrogels were prepared by the radical copolymerization of 2-hydroxyethyl methacrylate, itaconic acid and four different poly(alkylene glycol) (meth)acrylate components (Bisomers) in a water/ethanol mixture as solvent. The polymers swell in water at 25?C to yield homogeneous transparent hydrogels. All the hydrogels displayed pH sensitive behavior in buffers of the pH range from 2.20 to 7.40, under conditions similar to those of biological fluids. The presence of these two comonomers, which were added to HEMA, increased the swelling degree of the hydrogels and gave gels with better elasticity. The hydrogels were thermally stable in the vicinity of the physiological temperature (37?C). The copolymer containing pure poly(ethylene glycol) acrylate units generally had the best properties. The tests performed on the hydrogels confirmed that they were neither hemolytic nor cytotoxic. The copolymer samples showed better cell viability and less hemolytic activity than the PHEMA sample, confirming the assumption that poly(alkylene glycols) improve the biocompatibility of hydrogels. Due to their swelling and mechanical characteristics, as well as the very good biocompatibility and bioadhesive properties, poly(Bisomer/HEMA/IA) hydrogels are promising for utilization in the field of biomedicals, especially for the controlled release of drugs.

ChemInform Abstract: REACTIONS OF ALKYLENE GLYCOL PHOSPHOROUS MONOISOCYANATES WITH TRIMETHYLPYRUVONITRILE

1979 ◽  
Vol 10 (36) ◽  
Author(s):  
I. V. KONOVALOVA ◽  
T. A. FASKHUTDINOVA ◽  
L. A. BURNAEVA ◽  
T. G. MONAKHOVA ◽  
A. N. PUDOVIK
Keyword(s):  
Alkylene Glycol

ChemInform Abstract: REACTION OF ALKYLENE GLYCOL CHLOROPHOSPHITES WITH DICHLOROMETHYL ALKYL ETHER

1978 ◽  
Vol 9 (36) ◽  
Author(s):  
L. N. KRUTSKII ◽  
L. V. KRUTSKAYA ◽  
O. L. GORYACHEV ◽  
T. V. ZYKOVA ◽  
V. S. TSIVUNIN
Keyword(s):  
Alkyl Ether ◽  
Alkylene Glycol

Reaction of oxetanes with the acid chlorides of alkylene glycol phosphites

1971 ◽  
Vol 20 (9) ◽  
pp. 1978-1980
Author(s):  
O. N. Nuretdinova ◽  
B. A. Arbuzov ◽  
L. Z. Nikonova
Keyword(s):  
Acid Chlorides ◽  
Alkylene Glycol

scholarly journals The Copolymerization of Alkylene Glycol Nitrate Acrylates and Methacrylates

1970 ◽  
Vol 43 (1) ◽  
pp. 208-211
Author(s):  
Masafumi Moriya ◽  
Tadataka Yamashita
Keyword(s):  
Alkylene Glycol
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