Halloysite nanotubes as particulate emulsifier: Preparation of biocompatible drug-carrying PLGA microspheres based on pickering emulsion

2012 ◽  
Vol 125 (S1) ◽  
pp. E358-E368 ◽  
Author(s):  
Zengjiang Wei ◽  
Chaoyang Wang ◽  
Hao Liu ◽  
Shengwen Zou ◽  
Zhen Tong
2015 ◽  
Vol 216 (7) ◽  
pp. 714-720 ◽  
Author(s):  
Yang Hu ◽  
Shengwen Zou ◽  
Yu Yang ◽  
Zhen Tong ◽  
Chaoyang Wang

2019 ◽  
Vol 2 (5) ◽  
pp. 3169-3176 ◽  
Author(s):  
Giuseppe Cavallaro ◽  
Stefana Milioto ◽  
Läysän Nigamatzyanova ◽  
Farida Akhatova ◽  
Rawil Fakhrullin ◽  
...  

RSC Advances ◽  
2014 ◽  
Vol 4 (45) ◽  
pp. 23797-23806 ◽  
Author(s):  
Yunlei Zhang ◽  
Jianming Pan ◽  
Yongsheng Yan ◽  
Weidong Shi ◽  
Longbao Yu

Based on halloysite nanotubes (HNTs), precipitation polymerization and Pickering emulsion polymerization were firstly adopted to synthesize two composites i.e. HNTs–polystyrene(PSt)–polydivinylbenzene(DVB)(i) and HNTs–PSt–PDVB(ii), respectively.


2003 ◽  
Vol 20 (5) ◽  
pp. 569-579 ◽  
Author(s):  
S.-A. Seo ◽  
G. Khang ◽  
J. M. Rhee ◽  
J. Kim ◽  
H. B. Lee

Author(s):  
Sofia Negro ◽  
Liudmilla Boeva ◽  
Karla Slowing ◽  
Ana Fernandez-Carballido ◽  
Luis Garcia-García ◽  
...  
Keyword(s):  

Author(s):  
Anjali Pandya ◽  
Rajani Athawale ◽  
Durga Puro ◽  
Geeta Bhagwat

Background: The research work involves development of PLGA biodegradable microspheres loaded with dexamethasome for intraocular delivery. Objective: To design and evaluate long acting PLGA microspheres for ocular delivery of dexamethasone. Method: Present formulation involves the development of long acting dexamethasone loaded microspheres composed of a biodegradable controlled release polymer, Poly(D, L- lactide-co-glycolide) (PLGA), for the treatment of posterior segment eye disorders intravitreally. PLGA with monomer ratio of 50:50 of lactic acid to glycolic acid was used to achieve a drug release up to 45 days. Quality by Design approach was utilized for designing the experiments. Single emulsion solvent evaporation technique along with high pressure homogenization was used to facilitate formation of microspheres. Results: Particle size evaluation, drug content and drug entrapment efficiency were determined for the microspheres. Particle size and morphology was observed using Field Emission Gun-Scanning Electron Microscopy (FEG-SEM) and microspheres were in the size range of 1-5 μm. Assessment of drug release was done using in vitro studies and transretinal permeation was observed by ex vivo studies using goat retinal tissues. Conclusion: Considering the dire need for prolonged therapeutic effect in diseases of the posterior eye, an intravitreal long acting formulation was designed. Use of biodegradable polymer with biocompatible degradation products was a rational approach to achieve this aim. Outcome from present research shows that developed microspheres would provide a long acting drug profile and reduce the frequency of administration thereby improving patient compliance.


2020 ◽  
Author(s):  
Nabil Hayeemasae ◽  
Kannika Sahakaro ◽  
Hanafi Ismail

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