Synthesis of fluorescent methoxy poly(ethylene glycol)-b-Poly(ethyl cyanoacrylate)-2-(N-carbazolyl) ethyl methacrylate copolymer via living oxyanion-initiated polymerization

2011 ◽  
Vol 123 (6) ◽  
pp. 3575-3579 ◽  
Author(s):  
Xiaona Lin ◽  
Liandong Deng ◽  
Anjie Dong
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Ethyl Methacrylate ◽  
Ethyl Cyanoacrylate ◽  
Poly Ethylene ◽  
Methacrylate Copolymer

The Influences of Monomer Structure and Solvent on the Radical Copolymerization of Tertiary Amine and PEGylated Methacrylates

2021 ◽  
Author(s):  
Priscila Quiñonez-Angulo ◽  
Robin Hutchinson ◽  
Angel Licea-Claverie ◽  
Enrique Saldivar ◽  
Ivan Zapata-Gonzalez
Keyword(s):  
Ethylene Glycol ◽  
Methyl Ether ◽  
Tertiary Amine ◽  
Radical Copolymerization ◽  
Poly Ethylene Glycol ◽  
Ethyl Methacrylate ◽  
Monomer Structure ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

Tertiary Amine Methacrylates (TAMAs), such as 2-(N,N-diethylamino)ethyl methacrylate (DEAEMA) and 2-(N,N-dimethylamino)ethyl methacrylate (DMAEMA), and PEGylated (macro)monomers, such as 2-ethoxyethyl methacrylate (EEMA1) and poly(ethylene glycol) methyl ether methacrylates with 9 and...

scholarly journals Hybrid Mesoporous Silica Nanoparticles Grafted with 2-(tert-butylamino)ethyl Methacrylate-b-poly(ethylene Glycol) Methyl Ether Methacrylate Diblock Brushes as Drug Nanocarrier

Molecules ◽  
2020 ◽  
Vol 25 (1) ◽  
pp. 195 ◽  
Author(s):  
Abdullah M Alswieleh ◽  
Abeer M Beagan ◽  
Bayan M Alsheheri ◽  
Khalid M Alotaibi ◽  
Mansour D Alharthi ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Ethylene Glycol ◽  
Silica Nanoparticles ◽  
Methyl Ether ◽  
Diblock Copolymer ◽  
Mesoporous Silica Nanoparticles ◽  
Poly Ethylene Glycol ◽  
Ethyl Methacrylate ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

This paper introduces the synthesis of well-defined 2-(tert-butylamino)ethyl methacrylate-b-poly(ethylene glycol) methyl ether methacrylate diblock copolymer, which has been grafted onto mesoporous silica nanoparticles (PTBAEMA-b-PEGMEMA-MSNs) via atom transfer radical polymerization (ATRP). The ATRP initiators were first attached to the MSN surfaces, followed by the ATRP of 2-(tert-butylamino)ethyl methacrylate (PTBAEMA). CuBr2/bipy and ascorbic acid were employed as the catalyst and reducing agent, respectively, to grow a second polymer, poly(ethylene glycol) methyl ether methacrylate (PEGMEMA). The surface structures of these fabricated nanomaterials were then analyzed using Fourier Transform Infrared (FTIR) spectroscopy. The results of Thermogravimetric Analysis (TGA) show that ATRP could provide a high surface grafting density for polymers. Dynamic Light Scattering (DLS) was conducted to investigate the pH-responsive behavior of the diblock copolymer chains on the nanoparticle surface. In addition, multifunctional pH-sensitive PTBAEMA-b-PEGMEMA-MSNs were loaded with doxycycline (Doxy) to study their capacities and long-circulation time.

Synthesis and Self-Assembly of Well-Defined pH-Responsive Block Glycopolymers

2015 ◽  
Vol 815 ◽  
pp. 359-366 ◽  
Author(s):  
Qing Yun Yu ◽  
Lu Bin Lin ◽  
Xue Yu Xing ◽  
Hai Liang Dong ◽  
Xiao Ze Jiang ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Self Assembly ◽  
Phenylboronic Acid ◽  
Proton Nuclear Magnetic Resonance ◽  
Similar Degree ◽  
Random Structure ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Ethyl Methacrylate ◽  
Poly Ethylene

Two pH-responsive block glycopolymers, poly (ethylene glycol)-b-Poly (2- (diethylamino) ethyl methacrylate-co-2-gluconamidoethyl methacrylate) (PEG113-b-P(DEA55-co-GAMA12)) and poly (ethylene glycol)-b-poly (2-(diethylamino) ethyl methacrylate)-b-poly (2-gluconamido ethyl methacrylate) (PEG113-b-PDEA55-b-PGAMA15), were synthesized via atom transfer radical polymerization (ATRP) by directly or successively polymerization of GAMA and DEA monomers using a PEG-based macroinitiator, respectively, without protecting group chemistry. Those block glycopolymers were confirmed by proton Nuclear Magnetic Resonance (1H NMR) and Gel Permeation Chromatography (GPC), and their self-assembly behaviors were characterized by Transmission Electron Microscopy (TEM), Dynamic Light Scattering (DLS) and Zeta-potential. The results show both synthetic block glycopolymers were dissolved molecularly in aqueous solution at acidic pH (such as pH 3), thus it can reversibly convert to be two-layer micelles comprising DEA and GAMA cores, PEG coronas with size of around 50 nm, or micelles comprising DEA cores, GAMA and PEG outer coronas with bigger size of 70 nm for PEG113-b- P(DEA55-co-GAMA12) and PEG113-b-PDEA55-b-PGAMA15), respectively, at basic condition. Both glycopolymers have the micellization process at middle pH (pH 6-8), but possess different isoelectric points (pIs) (at pH 8.0 and 7.8) for their pH responsive block of PEG113-b-P(DEA55-co-GAMA12) and PEG113-b-PDEA55-b-PGAMA15 with DEA-co-GAMA random structure or DEA chain only, respectively. This study not only reveals the self-assembly of pH responsive block glycopolymers with different architectures by fixing similar degree polymerization (DP) of their blocks, but also provides a tool to investigate pH induced dynamic covalent interaction between glycopolymers and phenylboronic acid derivatives or a light for designing novel drug delivery carriers.

Sulfonated poly(ethylene glycol) containing methacrylate copolymer surfaces; preparation, characterization andin vitro biocompatibility

2004 ◽  
Vol 12 (4) ◽  
pp. 342-351 ◽  
Author(s):  
Ki Dong Park ◽  
Hyung Dal Park ◽  
Hee Jung Lee ◽  
Yong Ha Kim ◽  
Tooru Ooya ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Methacrylate Copolymer ◽  
Sulfonated Poly

Synthesis and thermo-responsive self-assembly behavior of amphiphilic copolymer β-CD–(PCL–P(MEO2MA-co-PEGMA))21 for the controlled intracellular delivery of doxorubicin

RSC Advances ◽  
2016 ◽  
Vol 6 (56) ◽  
pp. 50993-51004 ◽  
Author(s):  
Beibei Lu ◽  
Lei Li ◽  
Lulu Wei ◽  
Xuhong Guo ◽  
Jun Hou ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Self Assembly ◽  
Intracellular Delivery ◽  
Amphiphilic Copolymer ◽  
Poly Ethylene Glycol ◽  
Glycol Methacrylate ◽  
Ethyl Methacrylate ◽  
Assembly Behavior ◽  
Poly Ethylene

Well-defined amphiphilic β-cyclodextrin star-shaped copolymers with poly(ε-caprolactone)–poly(2-(2-methoxyethoxy)ethyl methacrylate)-co-poly(ethylene glycol)methacrylate) (β-CD–(PCL–P(MEO2MA-co-PEGMA))21 were synthesized via (ROP) and (ATRP).

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