Drug release from electrospun fibers of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) grafted with poly(N-vinylpyrrolidone)

2011 ◽  
Vol 124 (3) ◽  
pp. 1919-1928 ◽  
Author(s):  
Wei Wang ◽  
Jianda Cao ◽  
Ping Lan ◽  
Wen Wu
Keyword(s):  
Drug Release ◽  
Electrospun Fibers

Understanding drug release from PCL/gelatin electrospun blends

2016 ◽  
Vol 31 (6) ◽  
pp. 933-949 ◽  
Author(s):  
Hrishikesh R Munj ◽  
John J Lannutti ◽  
David L Tomasko
Keyword(s):  
Drug Release ◽  
Biomedical Applications ◽  
Drug Loading ◽  
Release Mechanism ◽  
Electrospun Fibers ◽  
Electrospun Scaffolds ◽  
Bioactive Properties ◽  
Complex Process ◽  
Rhodamine B Dye ◽  
Polymer Erosion

Electrospinning is one of the efficient processes to fabricate polymeric fibrous scaffolds for several biomedical applications. Several studies have published to demonstrate drug release from electrospun scaffolds. Blends of natural and synthetic electrospun fibers provide excellent platform to combine mechanical and bioactive properties. Drug release from polymer blends is a complex process. Drug release from polymer can be dominated by one or more of following mechanisms: polymer erosion, relaxation, and degradation. In this study, electrospun polycaprolactone (PCL)–gelatin blends are investigated to understand release mechanism of Rhodamine B dye. Also, this article summarizes the effect of high-pressure carbon dioxide on drug loading and release from PCL–gelatin fibers. Results indicate that release media diffusion is a dominant mechanism for PCL–gelatin electrospun fibers. Thickness of electrospun mat becomes critical for blends with gelatin. As gelatin is highly soluble in water and has tendency of gelation, it affects diffusion of release media in and out of scaffold. This article is a key step forward in understanding release from electrospun blends.

Tumor-Triggered Controlled Drug Release from Electrospun Fibers Using Inorganic Caps for Inhibiting Cancer Relapse

Small ◽  
2015 ◽  
Vol 11 (34) ◽  
pp. 4284-4291 ◽  
Author(s):  
Xin Zhao ◽  
Ziming Yuan ◽  
Lara Yildirimer ◽  
Jingwen Zhao ◽  
Zhi Yuan William Lin ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Electrospun Fibers ◽  
Cancer Relapse

scholarly journals Drug Delivery: Tumor-Triggered Controlled Drug Release from Electrospun Fibers Using Inorganic Caps for Inhibiting Cancer Relapse (Small 34/2015)

Small ◽  
2015 ◽  
Vol 11 (34) ◽  
pp. 4221-4221 ◽  
Author(s):  
Xin Zhao ◽  
Ziming Yuan ◽  
Lara Yildirimer ◽  
Jingwen Zhao ◽  
Zhi Yuan William Lin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Electrospun Fibers ◽  
Cancer Relapse

scholarly journals Effects of Electrode Reversal on the Distribution of Naproxen in the Electrospun Cellulose Acetate Nanofibers

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Zhuang Li ◽  
Hongliang Kang ◽  
Ning Che ◽  
Zhijing Liu ◽  
Pingping Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Hydrogen Bonds ◽  
Cellulose Acetate ◽  
Release Rate ◽  
Molecular Level ◽  
Electrospun Fibers ◽  
Release Rates ◽  
Hybrid Nanofibers ◽  
Morphology And Structure ◽  
Electrode Polarity

Naproxen (NAP)/cellulose acetate hybrid nanofibers were prepared by positive and reversed emitting electrodes electrospinning setups. The morphology and structure of the resultant nanofibers were characterized, and the NAP release behaviors were investigated. It was found that NAP dispersed in the CA matrix in molecular level, and no aggregation and dimers of NAP were found in the resultant NAP/CA hybrid nanofibers due to the formation of hydrogen bonds between NAP and CA. The nanofibers obtained by reversed emitting electrode electrospinning setup have a thicker diameter and a faster NAP release rate compared with those obtained by positive emitting electrode electrospinning setup. The faster drug release of NAP from nanofibers prepared by reversed emitting electrode electrospinning is due to the fact that the concentration of NAP molecules near the surface of the nanofibers is relatively higher than that of the nanofibers prepared by positive emitting electrode electrospinning setup. The effects of the electrode polarity on the distribution of drugs in nanofibers can be used to prepare hybrid electrospun fibers of different drug release rates, which may found applications in biomedical materials.

Ofloxacin Loaded Electrospun Fibers for Ocular Drug Delivery: Effect of Formulation Variables on Fiber Morphology and Drug Release

2016 ◽  
Vol 13 (3) ◽  
pp. 433-443 ◽  
Author(s):  
Ayşegül Karataş ◽  
Aslihan Hilal Algan ◽  
Nursel Pekel-Bayramgil ◽  
Fatih Turhan ◽  
Nurten Altanlar
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Ocular Drug Delivery ◽  
Electrospun Fibers ◽  
Fiber Morphology ◽  
Formulation Variables

Long-term drug release from electrospun fibers for in vivo inflammation prevention in the prevention of peritendinous adhesions

2013 ◽  
Vol 9 (7) ◽  
pp. 7381-7388 ◽  
Author(s):  
Changmin Hu ◽  
Shen Liu ◽  
Yang Zhang ◽  
Bin Li ◽  
Huilin Yang ◽  
...  
Keyword(s):  
Drug Release ◽  
Electrospun Fibers ◽  
In Vivo Inflammation

scholarly journals A Meta-Analysis of Wearable Contact Lenses for Medical Applications: Role of Electrospun Fiber for Drug Delivery

Polymers ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 185
Author(s):  
Hamed Hosseinian ◽  
Samira Hosseini ◽  
Sergio O. Martinez-Chapa ◽  
Mazhar Sher
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Contact Lenses ◽  
Electrospun Fiber ◽  
Drug Loading ◽  
High Surface ◽  
Medical Applications ◽  
Electrospun Fibers ◽  
Fiber Types

In recent years, wearable contact lenses for medical applications have attracted significant attention, as they enable continuous real-time recording of physiological information via active and noninvasive measurements. These devices play a vital role in continuous monitoring of intraocular pressure (IOP), noninvasive glucose monitoring in diabetes patients, drug delivery for the treatment of ocular illnesses, and colorblindness treatment. In specific, this class of medical devices is rapidly advancing in the area of drug loading and ocular drug release through incorporation of electrospun fibers. The electrospun fiber matrices offer a high surface area, controlled morphology, wettability, biocompatibility, and tunable porosity, which are highly desirable for controlled drug release. This article provides an overview of the advances of contact lens devices in medical applications with a focus on four main applications of these soft wearable devices: (i) IOP measurement and monitoring, (ii) glucose detection, (iii) ocular drug delivery, and (iv) colorblindness treatment. For each category and application, significant challenges and shortcomings of the current devices are thoroughly discussed, and new areas of opportunity are suggested. We also emphasize the role of electrospun fibers, their fabrication methods along with their characteristics, and the integration of diverse fiber types within the structure of the wearable contact lenses for efficient drug loading, in addition to controlled and sustained drug release. This review article also presents relevant statistics on the evolution of medical contact lenses over the last two decades, their strengths, and the future avenues for making the essential transition from clinical trials to real-world applications.

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