Clozapine recognition via molecularly imprinted polymers; bulk polymerization versus precipitation method

2011 ◽  
Vol 121 (6) ◽  
pp. 3590-3595 ◽  
Author(s):  
Seyed Ahmad Mohajeri ◽  
Gholamreza Karimi ◽  
Javad Aghamohammadian ◽  
Mehdi Rajabnia Khansari
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Bulk Polymerization ◽  
Precipitation Method ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

scholarly journals Molecularly Imprinted Polymers for Gossypol via Sol–Gel, Bulk, and Surface Layer Imprinting—A Comparative Study

Polymers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 602 ◽  
Author(s):  
Lulu Wang ◽  
Keke Zhi ◽  
Yagang Zhang ◽  
Yanxia Liu ◽  
Letao Zhang ◽  
...  
Keyword(s):  
Surface Layer ◽  
Adsorption Capacity ◽  
Adsorption Kinetics ◽  
Molecularly Imprinted Polymers ◽  
Sol Gel ◽  
Freundlich Isotherm ◽  
Bulk Polymerization ◽  
Order Kinetic ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Three gossypol molecularly imprinted polymers (MIPs) were prepared by bulk polymerization (MIP1), surface layer imprinting using silica gel as the support (MIP2), and the sol-gel process (MIP3). The as-prepared MIPs were characterized by SEM and nitrogen adsorption−desorption techniques to study the morphology structure. The adsorption experiments exhibited that MIP1 had adsorption capacity as high as 564 mg·g−1. The MIP2 showed faster adsorption kinetics than MIP1 and MIP3. The adsorption equilibrium could be reached for gossypol in 40 min. A selectivity study showed that the adsorption capacity of MIPs for gossypol was about 1.9 times higher than that of the structurally-similar analogs ellagic acid and 6.6 times higher than that of the quercetin. It was found that the pseudo-second-order kinetic model and the Freundlich isotherm model were more applicable for the adsorption kinetics and adsorption isotherm of gossypol binding onto the MIP1 and MIP2, respectively. Results suggested that among those three, the MIP2 was a desirable sorbent for rapid adsorption and MIP1 was suitable for selective recognition of gossypol.

scholarly journals Enhancement of Electrochemical Detection of Gluten with Surface Modification Based on Molecularly Imprinted Polymers Combined with Superparamagnetic Iron Oxide Nanoparticles

Polymers ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 91
Author(s):  
Dalawan Limthin ◽  
Piyawan Leepheng ◽  
Annop Klamchuen ◽  
Darinee Phromyothin
Keyword(s):  
Surface Modification ◽  
Electrochemical Detection ◽  
Molecularly Imprinted Polymers ◽  
Electrochemical Impedance ◽  
Superparamagnetic Iron Oxide ◽  
Precipitation Method ◽  
Simple Method ◽  
Molecularly Imprinted ◽  
Plate Electrode ◽  
Imprinted Polymers

Novel molecularly imprinted polymers (MIPs) represent a selectively recognized technique for electrochemical detection design. This rapid and simple method prepared via chemical synthesis consists of a monomer crosslinked with an initiator, whereas low sensitivity remains a drawback. Nanomaterials can improve charge transfer for MIP surface modification in order to overcome this problem. SPIONs have semiconductor and superparamagnetic properties that can enhance carrier mobility, causing high sensitivity of electrochemical detection. In this work, surface modification was achieved with a combination of MIP and SPIONs for gluten detection. The SPIONs were synthesized via the chemical co-precipitation method and mixed with MIPs by polymerizing gluten and methyl methacrylate (MMA), presented as a template and a monomer. Magnetic MIP (MMIP) was modified on a carbon-plate electrode. The morphology of modified electrode surfaces was determined by scanning electron microscopy–energy-dispersive X-ray spectrometry. The performance of the MMIP electrode was confirmed by cyclic voltammetry, amperometry, and electrochemical impedance spectroscopy. The MMIP electrode for gluten detection shows a dynamic linear range of 5–50 ppm, with a correlation coefficient of 0.994 and a low detection limit of 1.50 ppm, which is less than the U.S. Food and Drug Administration requirements (20 ppm); moreover, it exhibits excellent selectivity, sensitivity, stability, and reproducibility.

scholarly journals IDENTIFICATION OF DRIVING FORCES FOR THE RECOGNITION PROCESSES ON MOLECULARLY IMPRINTED POLYMERS

2013 ◽  
Vol 12 (2) ◽  
pp. 63-69 ◽  
Author(s):  
Natalia Denderz ◽  
Jozef Lehotay
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Driving Forces ◽  
Bulk Polymerization ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Imprinted Polymers ◽  
Retention Factors ◽  
Mobile Phases ◽  
Almost All ◽  
Derivatives Of

Abstract In this paper the thermodynamic analyses were used to calculate the contributions of entropic and enthalpic terms of the binding processes of selected derivatives of alkoxy-substituted phenylcarbamic acid (MEP) and phenolic acids (PAs) on the series of molecularly imprinted polymers (MIPs) and corresponding non-imprinted polymers (NIPs). All polymers were prepared by a bulk polymerization method with different porogens and functional monomers. The thermodynamic assessments were based on the quantification by HPLC measurements of the analytes tested in different mobile phases and at temperature range from 293 K to 333 K. The thermodynamic parameters were determined from the van’t Hoff plots - dependences between logarithms of the retention factors of studied analytes (ln k) and the inverse value of the temperature (1/T). Almost all data showed that enthalpic term was the dominating driving force for the investigated analytes.

scholarly journals Application of molecularly imprinted polymers for the separation and detection of aflatoxin

2020 ◽  
pp. 174751982098037
Author(s):  
Jian-Xiong He ◽  
Huan-Yu Pan ◽  
Li Xu ◽  
Ri-Yuan Tang
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Bulk Polymerization ◽  
Phase Extraction ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Molecular Imprinting Polymers ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Aflatoxins are extremely harmful carcinogens to humans and animals. In recent years, attention has been directed toward the application of molecular imprinting polymers for the separation and detection of aflatoxin. In this review, polymerization methods for the preparation of molecular imprinting polymers for aflatoxin detection, such as lump-bulk polymerization, spherical molecular imprinting polymer synthesis, surface-imprinted polymerization, and electropolymerization, are described. The applications of molecular imprinting polymers in solid-phase extraction, biosensors, and the surface-enhanced Raman detection of aflatoxin are also reviewed in this paper.

Synthesis of nicotinamide-imprinted polymers and their binding performances in organic and aqueous media

e-Polymers ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Pattarawarapan Mookda ◽  
Komkham Singha ◽  
Kareuhanon Weeranuch ◽  
Tayapiwatana Chatchai
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Binding Capacity ◽  
Aqueous Media ◽  
Bulk Polymerization ◽  
Molar Ratio ◽  
Imprinted Polymer ◽  
Isolation And Identification ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Imprinted Polymers

AbstractTo obtain molecularly imprinted polymers capable of selective rebinding with nicotinamide (NAM), NAM imprinted polymers were synthesized via bulk polymerization using various functional monomers and cross-linkers. The NAM recognition properties of these polymers were investigated in organic and aqueous solvents by equilibrium rebinding experiments. The results show that the imprinted polymer prepared using 1:4:4 molar ratio of NAM/MAA/TRIM in dichloromethane exhibited the greatest NAM binding capacity and selectivity. This polymer is potentially valuable for the analysis of NAM in complex matrices where selective isolation and identification are needed.

scholarly journals Synthesis, Characterization of Chlropheniramine maleate– Molecularly Imprinted Polymers and Their Application as Sensors for the Determination of the Drug in Some Pharmaceutical Preparations

2017 ◽  
Vol 30 (3) ◽  
pp. 44
Author(s):  
Marwa Raad ◽  
Khalaf Farris Alsamarrai ◽  
Yehya Kamal Al-Bayati
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Pharmaceutical Preparations ◽  
Bulk Polymerization ◽  
Selectivity Coefficient ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Polymer Electrodes ◽  
Ph Range

New chlropheniramine maleate (CPM) selective electrochemical membranes were prepared by using chlropheniramine maleate -molecularly imprinted polymers. MIP was prepared by bulk polymerization using 2-hydroxyethyl methacrylate (2-HEMA) as monomer, ethylene glycol dimethacrylate (EGDMA) as a cross-linker and a benzoyl peroxide (BPO) as an initiator at 600C.  Three CPM-MIP electrodes were constructed by using tri-tolyl Phosphate (ToCP), tris (2- ethyl hexyl) Phosphate (TEHP) and tributyl Phosphate (TBP) as plasticizers in PVC matrix.Electrode parameters including slopes, working concentrations ph. The interference effect in the presence of (Na+, Mg+2, Al+3, Glycine, Alanine, Arginine and Phenylalanine) was studied using the separated and mixed methods to determine the selectivity coefficient determination. NIP prepared by using the same composition of MIP molecularly imprinted polymer electrodes except the template (CPM). The slopes of CMPMIP are 21.00, 21.50 and 19.08 mV/ decade, linearity range for the electrodes around. (10-5 10-1) M, the stable at a pH range from 4.0 to 8.5 and lifetime ranged from 30 to 10 days. The suggested electrodes were successfully applied for the determine of CPM in some pharmaceutical preparations, which were given acceptable accuracy.

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