Taxol-loaded nanoparticles with methoxy poly(ethylene glycol)-b-poly(ε-caprolactone) as a novel additive in the outer aqueous phase

2011 ◽  
Vol 121 (4) ◽  
pp. 2386-2393 ◽  
Author(s):  
Yanting Zhang ◽  
Jingwen Hou ◽  
Changyun Qian ◽  
Lei Song ◽  
Shengrong Guo
1992 ◽  
Vol 609 (1-2) ◽  
pp. 219-227 ◽  
Author(s):  
Harry Walter ◽  
Frank D. Raymond ◽  
Derek Fisher

1991 ◽  
Vol 542 ◽  
pp. 397-411 ◽  
Author(s):  
Harry Walter ◽  
Eugene J. Krob ◽  
Louie Wollenberger

2004 ◽  
Vol 12 (5) ◽  
pp. 528-533 ◽  
Author(s):  
Kyoung Taek Kim ◽  
Im Hae Lee ◽  
Chiyoung Park ◽  
Yumi Song ◽  
Chulhee Kim

Nanomaterials ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 410 ◽  
Author(s):  
Byunghoon Kang ◽  
Jaewoo Lim ◽  
Hye-young Son ◽  
Yuna Choi ◽  
Taejoon Kang ◽  
...  

We designed a high-sensitivity magnetic resonance imaging contrast agent that could be used to diagnose diseases. First, magnetic nanocrystals were synthesized by a thermal decomposition method on an organic solvent to obtain a high magnetism and methoxy poly(ethylene glycol)-poly(lactic acid) as an amphiphilic polymer using the ring-opening polymerization method to stably disperse the magnetic nanocrystals in an aqueous phase. Subsequently, the magnetic nanoclusters simultaneously self-assembled with methoxy poly(ethylene glycol)-poly(lactic acid) using the nano-emulsion method to form magnetic nanoclusters. Because their shape was similar to a raspberry, they were named PEGylated magnetic nano-assemblies. The PEGylated magnetic nano-assemblies were dispersed stably in the aqueous phase with a uniform size of approximately 65–70 nm for an extended period (0 days: 68.8 ± 5.1 nm, 33 days: 69.2 ± 2.0 nm, and 44 days: 63.2 ± 5.6). They exhibited both enough of a magnetic resonance (MR) contrast effect and biocompatibility. In an in vivo study, the PEGylated magnetic nano-assemblies provided a high contrast effect for magnetic resonance images for a long time after one treatment, thereby improving the diagnostic visibility of the disease site.


1984 ◽  
Vol 30 (3) ◽  
pp. 441-443 ◽  
Author(s):  
J M Van Alstine ◽  
D E Brooks

Abstract Erythrocytes from multiple sclerosis patients differ significantly (p less than 0.005) from those from controls with regard to hydrophobic affinity partition in two-polymer aqueous-phase systems containing dextran, poly(ethylene glycol) and poly (ethylene glycol)-fatty acid esters. The most likely source of the abnormality is the cell membrane.


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