Gelatin based pH-sensitive hydrogels for colon-specific oral drug delivery: Synthesis, characterization, and in vitro release study

2010 ◽  
Vol 118 (5) ◽  
pp. 2642-2649 ◽  
Author(s):  
Amany I. Raafat
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
In Vitro Release ◽  
Ph Sensitive ◽  
Oral Drug ◽  
Release Study ◽  
Vitro Release

scholarly journals EFFECT OF NATURAL AND SYNTHETIC POLYMERS ON THE PROPERTIES OF CANDESARTAN CILEXETIL MATRIX TABLET PREPARED BY DRY GRANULATION

2016 ◽  
Vol 9 (9) ◽  
pp. 161
Author(s):  
Omar Saeb Salih ◽  
Roaa Abdalhameed Nief
Keyword(s):  
Drug Delivery ◽  
Candesartan Cilexetil ◽  
Oral Drug Delivery ◽  
In Vitro Release ◽  
Oral Drug ◽  
Matrix Tablet ◽  
Sustained Release Formulation ◽  
Weight Variation ◽  
Vitro Release

ABSTRACTObjective: The objective of this study is to develop a controlled release matrix tablet of candesartan cilexetil to reduce the frequency of administration,enhance bioavailability and improve patient compliance; a once daily sustained release formulation of candesartan cilexetil is desirable.Methods: The prepared tablets from F1 to F24 were evaluated with different evaluation parameters like weight variation, drug content, friability,hardness, thickness and swelling ability. In vitro release for all formulas were studied depends on the type and amount of each polymer, i.e. (16 mg,32 mg and 48 mg) respectively beside to the combination effect of polymers on the release of the drug from the tablet.Results: In vitro release showed that formula 13 had the faster release (100% after 4 h) which contained acacia (1:1) and the lowest sustain releasewas showed for F7 (73% after 8 h) which contained HPMC K100M (1:1). Formula 1 was an 89 % release after 8 h which contain eudragit RS100; F4was a 100 % release after 5 h which contain Na CMC, F10 was a 100% after 8 h which contain xanthan gum and F16 was a 100 % release after 5 hwhich contain tragacanth polymer. Formula 9 had a lower release than F7 and F8 respectively. Formula 7 can be used for sustain oral drug delivery ofcandesartan cilexetil while Formula 13 can be used in contrary as fast release tablets for faster response.Conclusion: Controlled drug delivery system is promising for less dosing and higher patient compliance.Keywords: Angiotensin II receptor antagonist, Hypertension, Matrix system, Control release.

Effect of Surfactants on Characteristic and In Vitro Release of Meloxicam Loaded in Deformable Liposomes

2012 ◽  
Vol 506 ◽  
pp. 457-460
Author(s):  
Sureewan Duangjit ◽  
Praneet Opanasopit ◽  
Theerasak Rojanarata ◽  
Tanasait Ngawhirunpat
Keyword(s):  
Drug Delivery ◽  
In Vitro Release ◽  
Entrapment Efficiency ◽  
Sodium Cholate ◽  
Drug Delivery Carrier ◽  
Release Study ◽  
Water Insoluble Drug ◽  
Vitro Release ◽  
Potential Use

The aim of this study was to investigate the effect of surfactants on characteristic and in vitro release of liposomes containing meloxicam (MX), model of water insoluble drug. The potential use of deformable liposomes for drug delivery system was developed and investigated. The formulation composed of constant amount of phosphatidylcholine (PC) and MX and various amounts of cholesterol (Chol), sodium cholate (NaChol), sodium oleate (NaO) and stearylamine (SA) was formulated by reverse phase evaporation method. The vesicle size, zeta potential, morphology, entrapment efficiency, loading efficiency, stability andin vitrorelease study were evaluated. The result indicated that the entrapment efficiency andin vitrorelease study of vesicle formulations containing surfactants were significantly higher than the conventional liposome and MX suspension. The formulation of 10:2:2:5 PC/MX/Chol/NaO provided the maximum entrapment efficiency and drug release. Our research suggested that MX loaded in deformable liposomes containing surfactants can be potentially used as a drug delivery carrier for water insoluble drug.

Biodegradable and pH-Sensitive Hydrogels for Potential Colon-Specific Drug Delivery: Characterization and In Vitro Release Studies

2008 ◽  
Vol 9 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Maria Antonietta Casadei ◽  
Giovanna Pitarresi ◽  
Rossella Calabrese ◽  
Patrizia Paolicelli ◽  
Gaetano Giammona
Keyword(s):  
Drug Delivery ◽  
In Vitro Release ◽  
Ph Sensitive ◽  
Specific Drug ◽  
Release Studies ◽  
Colon Specific Drug Delivery ◽  
Vitro Release

scholarly journals Preparation and Evaluation of a Novel Oral Microemulsion Drug Delivery System for Enhancing the Bioavailability of Diltiazem

2021 ◽  
Vol 70 (2) ◽  
Author(s):  
Ranajit Nath ◽  
Ratul Bhowmik ◽  
Rajarshi Chakraborty ◽  
Sourav Datta ◽  
Apala Chakraborty
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Drug Delivery ◽  
In Vitro Release ◽  
Immediate Release ◽  
Oral Drug ◽  
Accelerated Stability ◽  
Oral Drug Delivery System

Diltiazem, a calcium ion cellular influx inhibitor is known for its limited and variable bioavailability. This study is intended to explore the benefits of microemulsion formulation as an oral drug delivery system for immediate release to improve the bioavailability and efficacy of Diltiazem. Methods: Oil in water microemulsion was prepared using the simple water titration method. The optimized formulation was evaluated for physicochemical parameters like viscosity, pH, conductivity, and accelerated stability studies. In vitro release, diltiazem microemulsion was investigated.

Sign in / Sign up

Export Citation Format

Share Document