Synthesis and self-assembling behaviors of biotinylated pluronic/poly(lactic acid) biocompatible block copolymers in aqueous solutions

2010 ◽  
Vol 115 (3) ◽  
pp. 1573-1580 ◽  
Author(s):  
Zi Ling Li ◽  
Xiang Yuan Xiong ◽  
Yu Ping Li ◽  
Yan Chun Gong ◽  
Xing Xing Gui ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Block Copolymers ◽  
Aqueous Solutions ◽  
Poly Lactic Acid ◽  
Self Assembling

Effect of Block Length and Stereocomplexation on the Thermally Processable Poly(ε-caprolactone) and Poly(Lactic acid) Block Copolymers for Biomedical Applications

2019 ◽  
Vol 1 (12) ◽  
pp. 3354-3365
Author(s):  
Neha Mulchandani ◽  
Arvind Gupta ◽  
Kazunari Masutani ◽  
Sachin Kumar ◽  
Shinichi Sakurai ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Block Copolymers ◽  
Biomedical Applications ◽  
Block Length ◽  
Poly Lactic Acid

Supertough Poly(lactic acid) and Sustainable Elastomer Blends Compatibilized by PLLA-b-PMMA Block Copolymers as Effective A-b-C-Type Compatibilizers

2020 ◽  
Vol 59 (31) ◽  
pp. 13956-13968
Author(s):  
Hai Jiang ◽  
Yingli Ding ◽  
Juyang Liu ◽  
Arun Alagarsamy ◽  
Li Pan ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Block Copolymers ◽  
Poly Lactic Acid

scholarly journals Synthesis of Poly(lactic acid)-block-poly(N,N-dimethylaminoethyl methacrylate) Copolymers with Controllable Block Structures via Reversible Addition Fragmentation Polymerization from Aminolyzed Poly(lactic acid)

2018 ◽  
Vol 2018 ◽  
pp. 1-9
Author(s):  
Wenwen Yu ◽  
Lijing Zhu ◽  
Jiangao Shi ◽  
Cunting Zhao
Keyword(s):  
Lactic Acid ◽  
Block Copolymers ◽  
Raft Polymerization ◽  
Poly Lactic Acid ◽  
Pseudo First Order Reaction ◽  
Oh Groups ◽  
Dimethylaminoethyl Methacrylate ◽  
Reversible Addition ◽  
Raft Agent ◽  
Different Temperatures

Poly(lactic acid)-block-poly(N,N-dimethylaminoethyl methacrylate) (PLA-PDMAEMA) copolymers were synthesized from aminolyzed PLA via reversible addition fragmentation (RAFT) polymerization. PLA undergoes aminolytic degradation with ethylenediamine (EDA). The kinetics of the aminolysis reaction of PLA at different temperatures and EDA concentrations was investigated in detail. The molar masses of products rapidly decreased in the initial stage at low aminolytic degree. Meanwhile, reactive –NH2 and –OH groups were introduced to the end of shorter PLA chains and used as sites to further immobilize the RAFT agent. PLA-PDMAEMA block copolymers were synthesized. A pseudo-first-order reaction kinetics was observed for the RAFT polymerization of PDMAEMA at a low conversion. By controlling the aminolysis reaction of PLA and RAFT polymerization degree of DMAEMA, the length distributions of the PLA and PDMAEMA blocks can be controlled. This method can be extended to more systems to obtain block copolymers with controllable block structure.

Iron Tris(bipyridine)-Centered Poly(ethylene glycol)-Poly(lactic acid) Star Block Copolymers

2008 ◽  
Vol 41 (23) ◽  
pp. 9397-9405 ◽  
Author(s):  
Gina L. Fiore ◽  
Jessica L. Klinkenberg ◽  
Cassandra L. Fraser
Keyword(s):  
Lactic Acid ◽  
Block Copolymers ◽  
Ethylene Glycol ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Star Block Copolymers ◽  
Poly Ethylene

Vesicles from Pluronic/poly(lactic acid) block copolymers as new carriers for oral insulin delivery

2007 ◽  
Vol 120 (1-2) ◽  
pp. 11-17 ◽  
Author(s):  
Xiang Yuan Xiong ◽  
Yu Ping Li ◽  
Zi Ling Li ◽  
Chun Li Zhou ◽  
Kam Chiu Tam ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Block Copolymers ◽  
Insulin Delivery ◽  
Poly Lactic Acid ◽  
Oral Insulin

scholarly journals Paclitaxel Magnetic Core–Shell Nanoparticles Based on Poly(lactic acid) Semitelechelic Novel Block Copolymers for Combined Hyperthermia and Chemotherapy Treatment of Cancer

Pharmaceutics ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 213 ◽  
Author(s):  
Evi Christodoulou ◽  
Maria Nerantzaki ◽  
Stavroula Nanaki ◽  
Panagiotis Barmpalexis ◽  
Kleoniki Giannousi ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Lactic Acid ◽  
Block Copolymers ◽  
Polymeric Nanoparticles ◽  
Average Particle Size ◽  
In Vitro Release ◽  
Poly Lactic Acid ◽  
Average Particle ◽  
Chemotherapy Treatment ◽  
Cytotoxicity Studies

Magnetic hybrid inorganic/organic nanocarriers are promising alternatives for targeted cancer treatment. The present study evaluates the preparation of manganese ferrite magnetic nanoparticles (MnFe2O4 MNPs) encapsulated within Paclitaxel (PTX) loaded thioether-containing ω-hydroxyacid-co-poly(d,l-lactic acid) (TEHA-co-PDLLA) polymeric nanoparticles, for the combined hyperthermia and chemotherapy treatment of cancer. Initially, TEHA-co-PDLLA semitelechelic block copolymers were synthesized and characterized by 1H-NMR, FTIR, DSC, and XRD. FTIR analysis showed the formation of an ester bond between the two compounds, while DSC and XRD analysis showed that the prepared copolymers were amorphous. MnFe2O4 MNPs of relatively small crystallite size (12 nm) and moderate saturation magnetization (64 emu·g−1) were solvothermally synthesized in the sole presence of octadecylamine (ODA). PTX was amorphously dispersed within the polymeric matrix using emulsification/solvent evaporation method. Scanning electron microscopy along with energy-dispersive X-ray spectroscopy and transmission electron microscopy showed that the MnFe2O4 nanoparticles were effectively encapsulated within the drug-loaded polymeric nanoparticles. Dynamic light scattering measurements showed that the prepared nanoparticles had an average particle size of less than 160 nm with satisfactory yield and encapsulation efficiency. Diphasic PTX in vitro release over 18 days was observed while PTX dissolution rate was mainly controlled by the TEHA content. Finally, hyperthermia measurements and cytotoxicity studies were performed to evaluate the magnetic response, as well as the anticancer activity and the biocompatibility of the prepared nanocarriers.

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