Guided tissue regeneration with use of β-TCP/chitosan composite membrane

2009 ◽  
Vol 112 (5) ◽  
pp. 3127-3134 ◽  
Author(s):  
Shyh Ming Kuo ◽  
Shwu Jen Chang ◽  
Gregory Cheng-Chie Niu ◽  
Cheng-Wen Lan ◽  
Wen Tai Cheng ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Composite Membrane ◽  
Guided Tissue Regeneration ◽  
Chitosan Composite

scholarly journals Preparation and Bioactivity Properties of a Novel Composite Membrane of Fructose Mediatedβ-Tricalcium Pyrophosphate/(Polyethylene Glycol/Chitosan) for Guided Tissue Regeneration

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Jian-Wen Wang ◽  
Min-Hsiung Hon ◽  
Yi-Ming Kuo ◽  
Mei-Hui Chung
Keyword(s):  
Mechanical Property ◽  
Tissue Regeneration ◽  
Composite Membrane ◽  
Degradation Rate ◽  
Composite Membranes ◽  
Guided Tissue Regeneration ◽  
Glycol Chitosan ◽  
Cell Compatibility ◽  
Suitable Material

A novel composite membrane ofβ-tricalcium pyrophosphate (β-TCP) and fructose- (F-) mediated chitosan/poly(ethylene glycol) (CS/PEG) was prepared by thermally induced phase separation technique. The prepared composite membranes were characterized using scanning electron microscopy (SEM) and X-ray diffraction (XRD). The mechanical property, swelling, degradation, and cytotoxicity of the composite membranes were evaluated in vitro with respect to its potential for use as biodegradable guided tissue regeneration (GTR) membrane. In vitro degradation tests showed the composite membrane with a controllable degradation rate when changing theβ-TCP content. The incorporation ofβ-TCP granules also caused a significant enhancement of tensile strength. Whenβ-TCP content is controlled to 50 wt%, homogeneous composite membranes with well mechanical property and enzymatic degradation rate can be obtained. Cytotoxicity assay demonstrates that the composite membranes were nontoxic and had very good cell compatibility. Most importantly, the release of calcium ions and glucosamine from the composite membranes was proved to increase the cell proliferation of NIH3T3. The results of this study have indicated that this novel F-β-TCP/CS/PEG composite can be a suitable material for GTR applications.

A three-layered nano-carbonated hydroxyapatite/collagen/PLGA composite membrane for guided tissue regeneration

Biomaterials ◽  
2005 ◽  
Vol 26 (36) ◽  
pp. 7564-7571 ◽  
Author(s):  
Susan Liao ◽  
Wei Wang ◽  
Motohiro Uo ◽  
Shoji Ohkawa ◽  
Tsukasa Akasaka ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Composite Membrane ◽  
Guided Tissue Regeneration ◽  
Carbonated Hydroxyapatite
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