Heparin-coated poly(hydroxyethyl methacrylate/albumin) hydrogel networks:In vitro hemocompatibility evaluation for vascular biomaterials

2008 ◽  
Vol 109 (2) ◽  
pp. 749-757 ◽  
Author(s):  
Gülay Bayramoğlu ◽  
Meltem Yılmaz ◽  
Ertan Batislam ◽  
M. Yakup Arıca
Keyword(s):  
Hydroxyethyl Methacrylate ◽  
Vascular Biomaterials

Surface Modification by Nanobiomaterials for Vascular Tissue Engineering Applications

2020 ◽  
Vol 27 (10) ◽  
pp. 1634-1646 ◽  
Author(s):  
Huey-Shan Hung ◽  
Shan-hui Hsu
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Thrombus Formation ◽  
Vascular Grafts ◽  
Vascular Tissue Engineering ◽  
Great Success ◽  
Natural Polymers ◽  
Vascular Biomaterials

Treatment of cardiovascular disease has achieved great success using artificial implants, particularly synthetic-polymer made grafts. However, thrombus formation and restenosis are the current clinical problems need to be conquered. New biomaterials, modifying the surface of synthetic vascular grafts, have been created to improve long-term patency for the better hemocompatibility. The vascular biomaterials can be fabricated from synthetic or natural polymers for vascular tissue engineering. Stem cells can be seeded by different techniques into tissue-engineered vascular grafts in vitro and implanted in vivo to repair the vascular tissues. To overcome the thrombogenesis and promote the endothelialization effect, vascular biomaterials employing nanotopography are more bio-mimic to the native tissue made and have been engineered by various approaches such as prepared as a simple surface coating on the vascular biomaterials. It has now become an important and interesting field to find novel approaches to better endothelization of vascular biomaterials. In this article, we focus to review the techniques with better potential improving endothelization and summarize for vascular biomaterial application. This review article will enable the development of biomaterials with a high degree of originality, innovative research on novel techniques for surface fabrication for vascular biomaterials application.

Patterned Poly(2-hydroxyethyl methacrylate) Brushes on Silicon Surfaces Behave as “Tentacles” To Capture Ferritin from Aqueous Solution

2009 ◽  
Vol 1 (7) ◽  
pp. 1525-1532 ◽  
Author(s):  
Jem-Kun Chen ◽  
Zong-Yan Chen ◽  
Han-Ching Lin ◽  
Po-Da Hong ◽  
Feng-Chih Chang
Keyword(s):  
Aqueous Solution ◽  
Silicon Surfaces ◽  
Hydroxyethyl Methacrylate

scholarly journals Effect of 2-hydroxyethyl methacrylate on Streptococcus spp. biofilms

2011 ◽  
Vol 52 (3) ◽  
pp. 193-200 ◽  
Author(s):  
S. D’Ercole ◽  
M. Di Giulio ◽  
R. Grande ◽  
E. Di Campli ◽  
S. Di Bartolomeo ◽  
...  
Keyword(s):  
Hydroxyethyl Methacrylate

scholarly journals Mucoadhesive Nanoparticles for Drug Delivery to the Anterior Eye

Nanomaterials ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 1400
Author(s):  
Nicole Mangiacotte ◽  
Graeme Prosperi-Porta ◽  
Lina Liu ◽  
Megan Dodd ◽  
Heather Sheardown
Keyword(s):  
Morphological Analysis ◽  
Phenylboronic Acid ◽  
Spherical Particles ◽  
Target Tissue ◽  
Hydroxyethyl Methacrylate ◽  
Potential Analysis ◽  
Transmission Electron ◽  
Nanoparticle System ◽  
Zeta Potential Analysis

While the use of topical drops for the delivery of drugs to the anterior of the eye is well accepted, it is far from efficient with as little as 5% of the drug instilled on the eye actually reaching the target tissue. The ability to prolong the residence time on the eye is desirable. Based on the acceptability of 2-hydroxyethyl methacrylate based polymers in contact lens applications, the current work focuses on the development of a poly(2-hydroxyethyl methacrylate (HEMA)) nanoparticle system. The particles were modified to allow for degradation and to permit mucoadhesion. Size and morphological analysis of the final polymer products showed that nano-sized, spherical particles were produced. FTIR spectra demonstrated that the nanoparticles comprised poly(HEMA) and that 3-(acrylamido)phenylboronic acid (3AAPBA), as a mucoadhesive, was successfully incorporated. Degradation of nanoparticles containing N,N′-bis(acryloyl)cystamine (BAC) after incubation with DL-dithiothreitol (DTT) was confirmed by a decrease in turbidity and through transmission electron microscopy (TEM). Nanoparticle mucoadhesion was shown through an in-vitro zeta potential analysis.

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