Effect of different skin permeation enhancers on tack of a pressure sensitive adhesive

2005 ◽  
Vol 96 (4) ◽  
pp. 1287-1291 ◽  
Author(s):  
F. Lahootifard ◽  
S. Mojtaba Taghizadeh
Keyword(s):  
Skin Permeation ◽  
Permeation Enhancers ◽  
Pressure Sensitive Adhesive ◽  
Pressure Sensitive

Enhancement of Skin Permeation of a Hydrophilic Drug from Acryl-Based Pressure-Sensitive Adhesive Tape

2021 ◽  
Author(s):  
Takamasa Suzuki ◽  
Tomohiro Aoki ◽  
Masato Saito ◽  
Ichiro Hijikuro ◽  
Shoko Itakura ◽  
...  
Keyword(s):  
Skin Permeation ◽  
Adhesive Tape ◽  
Pressure Sensitive Adhesive ◽  
Pressure Sensitive ◽  
Hydrophilic Drug

scholarly journals Design, Development and Delivery of Rasagiline Mesylate from Monolithic Drug in Adhesive Matrix Patches

2020 ◽  
pp. 65-72
Author(s):  
Vipulbhai Mandli ◽  
Shailesh T. Prajapati
Keyword(s):  
Ex Vivo ◽  
Permeation Enhancers ◽  
Pressure Sensitive Adhesive ◽  
Uptake Study ◽  
Adhesion Testing ◽  
Pressure Sensitive ◽  
In Vitro Adhesion ◽  
Rasagiline Mesylate ◽  
Crystallization Study

The purpose of this research was to prepare and evaluate monolithic drug-in-adhesive type patches of Rasagiline Mesylate (RM) containing penetration enhancer and having seven day wear property. Preformulation studies like solubility in permeation enhancers, compatibility study, transmission study, uptake study and crystallization study of Rasagiline Mesylate in various pressure sensitive adhesive polymers were performed. Transdermal system was prepared by solvent casting method. The effects of various permeation enhancers (Propylene Glycol, Oleic Acid, Isopropyl Palmitate, and lauryl lactate) on the ex-vivo transcutaneous absorption of Rasagiline Mesylate through human cadaver skin were evaluated by modified Franz diffusion cell system. Ex-vivo transcutaneous absorption of prepared transdermal patch was performed using different concentration of Lauryl lactate (3%, 5%, and 7%). In-vitro Adhesion testing (Peel, tack shear etc.) was performed on different dry GSM (Grams per Square Meter) of patch like 80GSM, 100 GSM and 150 GSM. The final transdermal patches were tested for appearance, weight of matrix, thickness, % assay of drug content, in-vitro adhesion testing, cold flow study and ex-vivo skin permeation studies. Based on crystallization study and adhesion testing, Durotak-4098 (14% drug concentration) was selected as pressure sensitive adhesive. Patch containing Lauryl lactate showed highest cumulative permeation compared to other permeation enhancers. The patch containing 5% laurel lactate showed greater transdermal flux (2.36 µg/cm2 /hr). Patch with 150 dry GSM showing promising adhesion properties. Backing film Scotchpak 9723 and release liner Saint Gobain 8310 was selected based on transmission and uptake study of Rasagiline Mesylate. Stability study indicates that developed formulation remains stable. In conclusion, the present research confirms the practicability of developing Rasagiline Mesylate transdermal system.

Formulation and Evaluation of Isosorbide Dinitrate Acrylic Matrix Transdermal Patches

2011 ◽  
Vol 197-198 ◽  
pp. 1217-1220
Author(s):  
Ponwanit Jarenputtakrun ◽  
Praneet Opanasopit ◽  
Suwannee Panomsuk ◽  
Tanasait Ngawhirunpat
Keyword(s):  
Propylene Glycol ◽  
Isosorbide Dinitrate ◽  
Skin Permeation ◽  
Casting Method ◽  
Pressure Sensitive Adhesive ◽  
Transdermal Drug Delivery System ◽  
Pressure Sensitive Adhesives ◽  
Pressure Sensitive ◽  
Transdermal Patches

The aim of this study was to prepare and investigate the isosorbide dinitrate transdermal patches (IDPs) in the concentration of 40 mg/cm2. Acrylic pressure sensitive adhesives (PSA) were used to formulate IDPs. IDPs were prepared by casting method. The effect of content of PSA, and concentration of enhancer, propylene glycol, in the formulations were evaluated. IDPs were investigated for their thickness, weight/area ratio, adhesiveness and in vitro skin permeation. The higher the content of PSA in the formulation, the higher the thickness and the W/A ratio. Propylene glycol added in the formulation (2.5, 5, 10%) significantly enhanced the skin permeation of ISDN. The higher the content of PG, the higher the flux of ISDN through the skin. Our research suggests that isosorbide dinitrate loaded with 10% of propylene glycol in acrylic matrix pressure sensitive adhesive can be potentially used as a transdermal drug delivery system.

Transdermal drug delivery of fluvastatin sodium: Effect of permeation enhancers and pressure sensitive adhesive

2013 ◽  
Vol 6 (5) ◽  
pp. 573-578
Author(s):  
Chintankumar Jamanbhai Tank ◽  
Gourishankar Kalyanappa Kapse ◽  
Jayrajsinh Indrajitsinh Sarvaiya
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Permeation Enhancers ◽  
Pressure Sensitive Adhesive ◽  
Pressure Sensitive ◽  
Sodium Effect

Potential usefulness of solubility index for prediction of the skin permeation rate of 5-ISMN from pressure-sensitive adhesive tape

2001 ◽  
Vol 73 (2-3) ◽  
pp. 269-277 ◽  
Author(s):  
Kimihiro Sato ◽  
Naomi Mitsui ◽  
Tetsuya Hasegawa ◽  
Kenji Sugibayashi ◽  
Yasunori Morimoto
Keyword(s):  
Skin Permeation ◽  
Permeation Rate ◽  
Potential Usefulness ◽  
Adhesive Tape ◽  
Pressure Sensitive Adhesive ◽  
Pressure Sensitive

Passivation of pressure sensitive adhesive stickies by addition of acrylic fibers to OCC pulp before papermaking

TAPPI Journal ◽  
2016 ◽  
Vol 15 (10) ◽  
pp. 631-639
Author(s):  
MOHAMMAD HADI ARYAIE MONFARED ◽  
HOSSEIN RESALATI ◽  
ALI GHASEMIAN ◽  
MARTIN A. HUBBE
Keyword(s):  
Adverse Effects ◽  
Control Sample ◽  
Pressure Sensitive Adhesive ◽  
Acrylic Fiber ◽  
Burst Strength ◽  
Pressure Sensitive Adhesives ◽  
Pressure Sensitive ◽  
Tear Index ◽  
Breaking Length ◽  
Acrylic Fibers

This study investigated the addition of acrylic fiber to old corrugated container (OCC) pulp as a possible means of overcoming adverse effects of water-based pressure sensitive adhesives during manufacture of paper or paperboard. Such adhesives can constitute a main source of stickies, which hurt the efficiency of the papermaking process and make tacky spots in the product. The highest amount of acrylic fiber added to recycled pulps generally resulted in a 77% reduction in accepted pulp microstickies. The addition of acrylic fibers also increased pulp freeness, tear index, burst strength, and breaking length, though there was a reduction in screen yield. Hence, in addition to controlling the adverse effects of stickies, the addition of acrylic fibers resulted in the improvement of the mechanical properties of paper compared with a control sample.

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