Effects of some process parameters on the niflumic acid controlled release polymeric microspheres: Optimization using designs of experiments

2019 ◽  
Vol 14 (2) ◽  
pp. e2283 ◽  
Author(s):  
Nedjma Assas ◽  
Zineb Elbahri ◽  
Milad Baitiche ◽  
Ferhat Djerboua
Keyword(s):  
Controlled Release ◽  
Process Parameters ◽  
Niflumic Acid ◽  
Polymeric Microspheres ◽  
Designs Of Experiments

Development of controlled release inhalable polymeric microspheres for treatment of pulmonary hypertension

2013 ◽  
Vol 450 (1-2) ◽  
pp. 114-122 ◽  
Author(s):  
Aparna Saigal ◽  
Wai Kiong Ng ◽  
Reginald B.H. Tan ◽  
Sui Yung Chan
Keyword(s):  
Pulmonary Hypertension ◽  
Controlled Release ◽  
Polymeric Microspheres

Biodegradable polymeric microspheres of gelatin and carboxymethyl guar gum for controlled release of theophylline

2014 ◽  
Vol 71 (7) ◽  
pp. 1625-1643 ◽  
Author(s):  
Keerti V. Phadke ◽  
Lata S. Manjeshwar ◽  
Tejraj M. Aminabhavi
Keyword(s):  
Controlled Release ◽  
Guar Gum ◽  
Polymeric Microspheres

scholarly journals Microsponge as an Emerging Technique in Novel Drug Delivery System

2021 ◽  
Vol 11 (1) ◽  
pp. 171-182
Author(s):  
Payal D Borawake ◽  
Arumugam Kauslya ◽  
Jitendra V Shinde ◽  
Rajashree S Chavan
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Product Performance ◽  
Topical Drug Delivery ◽  
Polymeric Microspheres ◽  
Current Review ◽  
Improved Stability ◽  
Novel Drug

Numbers of developments are implemented in drug delivery system to achieve the goals of optimized efficacy, cost effectiveness of therapy. One of the latest, novel and highly evolving technologies is microsponge drug delivery system which gives controlled release and site specific delivery of active ingredients. They are highly cross linked, porous and polymeric microspheres with size range of 5-300µm. This system is emerging as valuable option for topical delivery of drugs due to characteristics like decreased side effects, improved stability, better formulation flexibility, superior product performance. It is having number of applications in oral, topical, ocular and biopharmaceuticals delivery. The current review describes microsponge technology and details of the formulation methods, evaluation, programmable release mechanisms and applications.   Keywords: Microsponges; Controlled release; Quasi emulsion solvent diffusion; Programmable drug release; Oral administration; Topical drug delivery.

Preparation of novel polymeric microspheres for controlled release of finasteride

2007 ◽  
Vol 342 (1-2) ◽  
pp. 82-86 ◽  
Author(s):  
Dongming Peng ◽  
Kelong Huang ◽  
Yanfei Liu ◽  
Suqin Liu
Keyword(s):  
Controlled Release ◽  
Polymeric Microspheres

scholarly journals Preparation and Optimization of Agrochemical 2,4-D Controlled Release Microparticles using Designs of Experiments

2018 ◽  
Vol 62 (1) ◽  
Author(s):  
Fatima Zohra BELMOKHTAR ◽  
Zineb ELBAHRI ◽  
Mohamed ELBAHRI
Keyword(s):  
Controlled Release ◽  
Large Range ◽  
Polymer Concentration ◽  
Methyl Cellulose ◽  
Interactive Effects ◽  
Evaporation Technique ◽  
Emulsification Solvent Evaporation ◽  
Designs Of Experiments ◽  
Initial Drug ◽  
Acetate Butyrate

In the present paper, factorial designs of experiments (DOE) were built in the aim of preparing new solid optimized controlled release microparticles charged with the herbicide 2,4-D and, also investigating the influence of some process and encapsulation variables. Composed from mixtures of ethylcellulose (EC) / hydroxy propyl methyl cellulose (HPMC), cellulose acetate butyrate butyryle (CAB) / HPMC and pure CAB as biodegradable polymeric matrices, the microparticles were prepared by emulsification-solvent evaporation technique. Then, the effect of some parameters such as the stirring speed of emulsification, initial drug concentration and polymer concentration were studied. Depending on the selected variables, a large range of microparticles’ size was obtained; from 25 to 208 µm of d<sub>10</sub> and the 2,4-D content reached 69%. Also, different release profiles accompanied with a burst effect were obtained. Finaly, by modelling using Minitab 16.1 software, the main and interactive effects of these variables on the microparticles’ chacteristics (size, drug entrapment and drug release) were evaluated.

scholarly journals Development and characterization of polymeric microspheres for controlled release protein loaded drug delivery system

2008 ◽  
Vol 70 (3) ◽  
pp. 303 ◽  
Author(s):  
S Ravi ◽  
KK Peh ◽  
Yusrida Darwis ◽  
BKrishna Murthy ◽  
TRaghu Raj Singh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polymeric Microspheres
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