Lipase‐mediated synthesis of neopentyl glycol diester using a combination of reduced and standard pressure

2021 ◽  
Author(s):  
Ji Won Kim ◽  
Byung Hee Kim ◽  
Yangha Kim ◽  
Moon‐Won Lee ◽  
Dong Joong Im ◽  
...  
Keyword(s):  
Neopentyl Glycol ◽  
Standard Pressure

scholarly journals Effects of 18F-fluorinated neopentyl glycol side-chain on the biological characteristics of stilbene amyloid-β PET ligands

2021 ◽  
Vol 94-95 ◽  
pp. 38-45
Author(s):  
Tetsuro Tago ◽  
Jun Toyohara ◽  
Ryo Fujimaki ◽  
Maho Tatsuta ◽  
Ruichong Song ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Biological Characteristics ◽  
Side Chain ◽  
Neopentyl Glycol

scholarly journals Effects of low versus standard pressure pneumoperitoneum on renal syndecan-1 shedding and VEGF receptor-2 expression in living-donor nephrectomy: a randomized controlled study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Dita Aditianingsih ◽  
Chaidir Arif Mochtar ◽  
Aida Lydia ◽  
Nuryati Chairani Siregar ◽  
Nur Ita Margyaningsih ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Low Pressure ◽  
Donor Nephrectomy ◽  
Intraabdominal Pressure ◽  
Vascular Endothelial ◽  
Pressure Group ◽  
Peritubular Capillary ◽  
Living Donor Nephrectomy ◽  
Standard Pressure ◽  
Renal Tubular

Abstract Background Laparoscopic nephrectomy is a preferred technique for living kidney donation. However, positive-pressure pneumoperitoneum may have an unfavorable effect on the remaining kidney and other distant organs due to inflamed vascular endothelium and renal tubular cell injury in response to increased systemic inflammation. Early detection of vascular endothelial and renal tubular response is needed to prevent further kidney injury due to increased intraabdominal pressure induced by pneumoperitoneum. Transperitoneal laparoscopic living donor nephrectomy represented a human model of mild increasing intraabdominal pressure. This study aimed to assess the effect of increased intraabdominal pressure on vascular endothelium and renal tubular cells by comparing the effects of low and standard pressure pneumoperitoneum on vascular endothelial growth factor receptor-2 (VEGFR-2) expression and the shedding of syndecan-1 as the early markers to a systemic inflammation. Methods We conducted a prospective randomized study on 44 patients undergoing laparoscopic donor nephrectomy. Subjects were assigned to standard (12 mmHg) or low pressure (8 mmHg) groups. Baseline, intraoperative, and postoperative plasma interleukin-6, syndecan-1, and sVEGFR-2 were quantified by ELISA. Syndecan-1 and VEGFR-2 expression were assessed immunohistochemically in renal cortex tissue. Renal tubule and peritubular capillary ultrastructures were examined using electron microscopy. Perioperative hemodynamic changes, end-tidal CO2, serum creatinine, blood urea nitrogen, and urinary KIM-1 were recorded. Results The low pressure group showed lower intra- and postoperative heart rate, intraoperative plasma IL-6, sVEGFR-2 levels and plasma syndecan-1 than standard pressure group. Proximal tubule syndecan-1 expression was higher in the low pressure group. Proximal-distal tubules and peritubular capillary endothelium VEGFR-2 expression were lower in low pressure group. The low pressure group showed renal tubule and peritubular capillary ultrastructure with intact cell membranes, clear cell boundaries, and intact brush borders, while standard pressure group showed swollen nuclei, tenuous cell membrane, distant boundaries, vacuolizations, and detached brush borders. Conclusion The low pressure pneumoperitoneum attenuated the inflammatory response and resulted in reduction of syndecan-1 shedding and VEGFR-2 expression as the renal tubular and vascular endothelial proinflammatory markers to injury due to a systemic inflammation in laparoscopic nephrectomy. Trial registration ClinicalTrials.gov NCT:03219398, prospectively registered on July 17th, 2017.

scholarly journals Effect of standard pressure angle on the fatigue strength of nitrided gears.

1987 ◽  
Vol 53 (492) ◽  
pp. 1844-1851
Author(s):  
Akira YOSHIDA ◽  
Komei FUJITA ◽  
Kiichi MIYANISHI ◽  
Kenji HIGASHI ◽  
Yuji OHUE ◽  
...  
Keyword(s):  
Fatigue Strength ◽  
Pressure Angle ◽  
Standard Pressure
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