Application of Response Surface Methodology for the Optimization of β‐Carotene‐Loaded Nanostructured Lipid Carrier from Mixtures of Palm Stearin and Palm Olein

2019 ◽  
Vol 97 (2) ◽  
pp. 213-223 ◽  
Author(s):  
Miftakhur Rohmah ◽  
Sri Raharjo ◽  
Chusnul Hidayat ◽  
Ronny Martien
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Palm Olein ◽  
Palm Stearin ◽  
Nanostructured Lipid Carrier ◽  
Β Carotene

scholarly journals Application of Box Behnken Design and Response Surface Methodology for Optimization Sonication Conditions of Nanostructured Lipid Carrier from Mixtures of Palm Stearin and Palm Olein

2021 ◽  
pp. 522-528
Author(s):  
Akbartina Solikah
Keyword(s):  
Particle Size ◽  
Response Surface Methodology ◽  
Zeta Potential ◽  
Response Surface ◽  
Palm Olein ◽  
Palm Stearin ◽  
Nanostructured Lipid Carriers ◽  
Polydispersity Index ◽  
Nanostructured Lipid Carrier ◽  
Dependent Variables

The study aimed to determine the optimum conditions of the sonication in the manufacture of nanostructured lipid carriers (NLC). Nanostructured lipid carriers were developed using a mixture of palm stearin and palm olein, water, and tween as surfactants. Optimization was carried out to obtain nanostructured lipid carriers with a size below 200nm, zeta potential + 30 mV, and polydispersity index below 0.5. Optimization of NLC using response surface methodology and Box-Behnken experimental design. The independent variables were amplitude (A, kHz), pulse on pulse off (B, minute), and time of sonication (C, minute) each at three levels, while dependent variables were zeta potential (Y1, mV), particle size (Y2, nm), and polydispersity index (Y3). Measurement for dependent variables using the Zetasizer Nano ZS particle size analyzer utilized with Malvern software (Malvern, UK). The optimum formulation was obtained at a combination of amplitude (35 kHz), pulse on pulse off (pulse on 9 pulses off 3), and time of sonication (3 minutes 25 seconds ). This resulted in NLC having particle size 127.9 nm, polydispersity index 0.191, the zeta potential of -27.3 mV.

scholarly journals Development and Characterization of Poly-ε-caprolactone Nanocapsules Containing β-carotene Using the Nanoprecipitation Method and Optimized by Response Surface Methodology

2020 ◽  
Vol 63 ◽  
Author(s):  
Renata Calegari Lino ◽  
Sabrina Matos de Carvalho ◽  
Carolina Montanheiro Noronha ◽  
William Gustavo Sganzerla ◽  
Cleonice Gonçalves da Rosa ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Nanoprecipitation Method ◽  
Β Carotene

scholarly journals Synthesis of esterified solid fat from fractionated rapeseed oil and palm stearin modeling by response surface methodology

2012 ◽  
Vol 9 (2) ◽  
pp. 273-282
Author(s):  
MA Alim ◽  
MA Alim ◽  
P Wessman ◽  
PC Dutta
Keyword(s):  
Response Surface Methodology ◽  
Reaction Time ◽  
Response Surface ◽  
Rapeseed Oil ◽  
Total Sterol ◽  
Palm Stearin ◽  
The Other ◽  
Coefficient Of Determination ◽  
Solid Fat ◽  
Significant Term

The main purpose of the study was to produce esterified solid fat (ESF) from fractionated rapeseed oil and palm   stearin through lipase-catalyzed reaction. The response surface methodology (RSM) was applied for optimization of   three reaction factors such as substrate mole ratio, enzyme percent, and reaction time. The design was adequate   and reproducible due to satisfactory levels of coefficient of determination (R2, 0.98) for both cases and coefficient   variation (CV, 4.06 for SFC at 10 °C and 7.95 for SFC at 30 °C, respectively). The substrate mole ratio was the   significant term for affecting the response of SFC (P<0.05) rather than reaction time and enzyme percent. Based on   ridge analysis, the production of ESF with SFC 51.48 ±0.94 % at 10 ºC would be predicted by the combinations of   optimized 24.07 h reaction time, 10.66 % enzyme and 1: 1.52 substrate mole ratios. On the other hand, the SFC of   21.44±0.83 at 30 ºC would be predicted by the combinations of optimized 24.37 h reaction time, 10.23 % enzyme and   1: 1.5 substrate mole ratios. The ESF contained mainly of palmitic (45.1%), oleic (40.8%), linoleic (5.6%) and stearic   (4.5%) acids, respectively. The total sterol and tocopherol contents of ESF were 243.27 mg/100g and 19.26 mg/100 g,   respectively. Therefore, these results in this study suggested that RSM can be used to optimize the lipase-catalyzed   synthesis of ESF with suitable physical characteristics.   DOI: http://dx.doi.org/10.3329/jbau.v9i2.11040   J. Bangladesh Agril. Univ. 9(2): 273–282, 2011

Formulation optimization of dihydroartemisinin nanostructured lipid carrier using response surface methodology

2010 ◽  
Vol 197 (1-2) ◽  
pp. 120-128 ◽  
Author(s):  
Xiaoyun Zhang ◽  
Jianping Liu ◽  
Hua Qiao ◽  
Huan Liu ◽  
Jingman Ni ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Nanostructured Lipid Carrier ◽  
Formulation Optimization
Sign in / Sign up

Export Citation Format

Share Document