Thermotropic properties of ferrocene derivatives bearing a cholesteryl unit: structure-properties correlations

2005 ◽  
Vol 19 (9) ◽  
pp. 1022-1037 ◽  
Author(s):  
Daniela Apreutesei ◽  
Gabriela Lisa ◽  
Hiroki Akutsu ◽  
Nicolae Hurduc ◽  
Shin'ichi Nakatsuji ◽  
...  
Keyword(s):  
Ferrocene Derivatives ◽  
Unit Structure ◽  
Thermotropic Properties ◽  
Structure Properties

Influence of Chemical Structure on Processing and Thermotropic Properties of Poly(siloxane-azomethine)s

2007 ◽  
Vol 19 (5-6) ◽  
pp. 541-552 ◽  
Author(s):  
Carmen Racles ◽  
Vasile Cozan ◽  
Istvan Sajo
Keyword(s):  
Chemical Structure ◽  
Condensation Reaction ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Aromatic Diamines ◽  
Redistribution Reaction ◽  
Insoluble Polymers ◽  
Mesomorphic Properties ◽  
Thermotropic Properties ◽  
Structure Properties

A disiloxane dialdehyde was obtained from bis (chloromethyl)disiloxane and p-hydroxybenzal-dehyde and it was used in an equilibration (redistribution) reaction to synthesize an oligomeric dialdehyde. By solution polycondensation, starting from bis(formyl-p-phenoxymethyl)tetramethyldisiloxane and different organic diamines, poly(azomethine)s were obtained. In the case of aromatic diamines with high rigidity, which gave insoluble polymers, different approaches were tested in order to improve the solubility: the use of the dialdehyde having longer siloxane chain, or of a siloxane diamine in a copoly-condensation reaction. The polymers’ structures were confirmed by IR and 1H NMR spectroscopy and by elemental analysis. The structure-properties relationship was studied in terms of solubility, thermal and thermotropic behavior. Most of the obtained poly(azomethine)s has mesomorphic properties, which were studied by polarized optical microscopy (POM), differential scanning calorimetry (DSC) and X-ray diffraction. The influence of aromatic diamines’ chemical structure on the processability of the siloxane-organic poly(azomethine)s was emphasized.

Trace nanoanalysis

1994 ◽  
Vol 52 ◽  
pp. 940-941
Author(s):  
D. E. Newbury ◽  
R. D. Leapman
Keyword(s):  
High Performance ◽  
Secondary Ion Mass Spectrometry ◽  
Detection Efficiency ◽  
Volume Element ◽  
And Performance ◽  
Trace Constituents ◽  
Secondary Ion ◽  
Concentration Levels ◽  
Structure Properties

Trace constituents, which can be very loosely defined as those present at concentration levels below 1 percent, often exert influence on structure, properties, and performance far greater than what might be estimated from their proportion alone. Defining the role of trace constituents in the microstructure, or indeed even determining their location, makes great demands on the available array of microanalytical tools. These demands become increasingly more challenging as the dimensions of the volume element to be probed become smaller. For example, a cubic volume element of silicon with an edge dimension of 1 micrometer contains approximately 5×1010 atoms. High performance secondary ion mass spectrometry (SIMS) can be used to measure trace constituents to levels of hundreds of parts per billion from such a volume element (e. g., detection of at least 100 atoms to give 10% reproducibility with an overall detection efficiency of 1%, considering ionization, transmission, and counting).

Advancing the use of Voronoi–Dirichlet polyhedra to describe interactions in organic molecular crystal structures by the example of galunisertib polymorphs

CrystEngComm ◽  
2021 ◽  
Author(s):  
Viktor N. Serezhkin ◽  
Anton V. Savchenkov
Keyword(s):  
Crystal Structures ◽  
Molecular Crystal ◽  
Noncovalent Interactions ◽  
Organic Molecular Crystal ◽  
Universal Approach ◽  
Structure Properties

The universal approach for studying structure/properties relationships shows that every polymorph of galunisertib is characterized with unique noncovalent interactions.

Synthetic Zeolites- Structure Properties and Application Area

2012 ◽  
Vol 3 (6) ◽  
pp. 78-80 ◽  
Author(s):  
Richa Gangele ◽  
◽  
Priya Pawaiya ◽  
Yogesh Pandey
Keyword(s):  
Application Area ◽  
Synthetic Zeolites ◽  
Structure Properties

NEW COMPLEXES OF 2-(1H-1, 2, 4-TRIAZOL-3-YL) PYRIDINE WITH Co(II), Cd(II), Rh(III), IONS: SYNTHESIS, STRUCTURE, PROPERTIES AND POTENTIAL APPLICATIONS

2015 ◽  
Vol 14 (2) ◽  
pp. 389-397
Author(s):  
Corneliu S. Stan ◽  
Petronela Horlescu ◽  
Daniel Sutiman ◽  
Carmen Mita ◽  
Cristian Peptu ◽  
...  
Keyword(s):  
Potential Applications ◽  
Structure Properties

New Ferrocene Compounds as Selective Cyclooxygenase (COX-2) Inhibitors: Design, Synthesis, Cytotoxicity and Enzyme-inhibitory Activity

2018 ◽  
Vol 18 (2) ◽  
pp. 295-301 ◽  
Author(s):  
Shabnam Farzaneh ◽  
Elnaz Zeinalzadeh ◽  
Bahram Daraei ◽  
Soraya Shahhosseini ◽  
Afshin Zarghi
Keyword(s):  
Cell Lines ◽  
Inhibitory Activity ◽  
Fibroblast Cell ◽  
Breast Cancer Cell Lines ◽  
Ferrocene Derivatives ◽  
Cox 2 ◽  
Cytotoxicity Effects ◽  
Cox 2 Inhibitors ◽  
Mcf 7

Background: Due to the astonishing properties of ferrocene and its derivatives, it has a broad application in diverse areas. Numerous ferrocene derivatives demonstrated anti-proliferative activity. Also COX-2, as a key isoenzyme for production of prostaglandins, is frequently overexpressed in various cancers. It is now recognized that COX-2 over expression promotes tumorigenic functions which can be suppressed by COX-2 inhibitors, a phenomenon useful for the preventing of tumor progression. The combination of COX-2 inhibitors with other anti-cancer or cancer prevention drugs may reduce their side effects in future cancer prevention and treatment. Objective: Owing to high anticancer potential of ferrocene derivatives and considerable COX-2 inhibitory and cytotoxicity effects of our previously synthesized chalcones, we decided to incorporate the ferrocenyl moiety into appropriate COX-2 inhibitor chalcone based scaffold, to evaluate COX-2 inhibitory activity as well as anticancer activities. Methods: Chalcones were synthesized via clasien-schmidt condensation of methylsulfonyl aldehyde and acetyl ferrocene. Further different amines with solvent free and ultra sound condition were reacted with chalcones to have different 1-ferrocenyl-3-amino carbonyl compounds. Docking study was carried out with Auto Dock vina software. All the newly-synthesized compounds were evaluated for their cyclooxygenase-2 (COX-2) inhibitory activity using chemiluminescent enzyme assays as well as cytotoxicity activity against MCF-7 and T47D and fibroblast cell lines by MTT assay. Results: In vitro COX-1/COX-2 inhibition studies demonstrated that all compounds were selective inhibitors of the COX-2 isozyme with IC50 values in the highly potent 0.05-0.12 µM range, and COX-2 selectivity indexes (SI) in the 148.3-313.7 range. These results indicated that either potency or selectivity of COX-2 inhibitory activity was affected by the nature and size of the substituents on C-3 of propane-1-one. Also anti-proliferative and toxicity activities of synthesized compounds against breast cancer cell lines MCF-7 and T47D and fibroblast cell lines showed that the synthesized compounds had mild to moderate cytotoxicity against MCT7 and T47D breast cancer cell lines at 10 µM concentration. In vitro COX-1/COX-2 inhibition studies and anticancer activity against MCF-7, identified 1-ferrocenyl-3-(4-methylsulfonylphenyl) propen-1-one as a potent compound (IC50 COX-2 = 0.05 µM, MCF-7: % inhibition (at concentration of 10 µM) = 32.7%), and also 1-ferrocenyl-3- (propan-1-amine)-3-(4-methylsulfonylphenyl) propan-1-one showed the most selectivity on COX-2 inhibition (selectivity index= 313.7). Conclusion: A novel group of ferrocene compounds, possessing a methyl sulfonyl COX-2 pharmacophore were synthesized to investigate the effect of different substituents on selectivity and potency of COX-2 inhibitory activity and their cytotoxicity effects. This study indicates that 1-ferrocenyl-3-amino carbonyl compounds having ferrocene motif and methyl sulfonyl COX-2 pharmacophore is a suitable scaffold to design COX-2 inhibitors and anti-cancer agents.

Substituent effect on wave numbers of C=O valence vibrations in ferrocene derivatives

1983 ◽  
Vol 48 (6) ◽  
pp. 1635-1646 ◽  
Author(s):  
Alexander Perjéssy ◽  
Štefan Toma
Keyword(s):  
Linear Correlation ◽  
Substituent Effect ◽  
Empirical Relation ◽  
Ferrocene Derivatives ◽  
Wave Numbers ◽  
Complex Structural ◽  
Transmission Factors

Wave numbers of C=O valence vibrations of 83 ferrocene derivatives have been measured in tetrachloromethane. For a series of 154 compounds containing ferrocene skeleton linear correlation has been found between wave numbers of C=O vibration and X+(R) constants of structural fragments in the sense of modified and extended Seth-Paul-Van Duyse equation. Validity has been verified of the recently derived empirical relation for calculation of the X+(R) constants of complex structural fragments from values of constants of substituents and transmission factors for simple structural groupings. The transmission factors γ and π' for 1,3- and 1,1'-ferrocene system have been found to be well applicable to calculation of constants of structural fragments containing ferrocene skeleton.

Hydrophobic Ferrocene Derivatives as Potential Standards in Electrochemistry

1997 ◽  
Vol 62 (2) ◽  
pp. 185-198 ◽  
Author(s):  
Jaroslav Podlaha ◽  
Petr Štěpnička ◽  
Róbert Gyepes ◽  
Vladimír Mareček ◽  
Alexander Lhotský ◽  
...  
Keyword(s):  
Surface Tension ◽  
Cyclic Voltammetry ◽  
Redox Potential ◽  
Diffusion Coefficients ◽  
Carbon Electrodes ◽  
X Ray Diffraction ◽  
Ferrocene Derivatives ◽  
X Ray ◽  
Special Cases ◽  
As Solubility

Ferrocene (FcH) derivatives monosubstituted by palmitoyl (1), hexadecyl (2), 1-adamantoyl (3) or 1-adamantylmethyl (4) groups were sythesized and characterized by NMR, mass and 57Fe Mossbauer spectroscopy. The structure of 1-adamantoylferrocene was determined by single-crystal X-ray diffraction. Cyclic voltammetry on gold and glass-like carbon electrodes demonstrated that the compounds can serve as electrochemical standards for special cases since their ferrocene/ferricinium redox potential remains stable and reversible, while the properties such as solubility, diffusion coefficients and surface tension are strongly solvent-dependent.

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