Synthesis, spectroscopic, theoretical and biological evaluation of novel Schiff base complexes of divalent transition metals

2021 ◽  
Author(s):  
Kiran Singh ◽  
Preeti Siwach
Keyword(s):  
Schiff Base ◽  
Transition Metals ◽  
Biological Evaluation ◽  
Schiff Base Complexes

2-[18F]Fluorophenylalanine: Synthesis by Nucleophilic 18F-Fluorination and Preliminary Biological Evaluation

Synthesis ◽  
2019 ◽  
Vol 51 (03) ◽  
pp. 664-676 ◽  
Author(s):  
Bernd Neumaier ◽  
Daniel Modemann ◽  
Boris Zlatopolskiy ◽  
Elizaveta Urusova ◽  
Johannes Zischler ◽  
...  
Keyword(s):  
Amino Acids ◽  
Schiff Base ◽  
Biological Evaluation ◽  
Schiff Base Complexes ◽  
Biological Study ◽  
Automated Synthesis ◽  
Pet Tracer ◽  
Iodonium Salt ◽  
Acidic Conditions

2-[18F]Fluorophenylalanine (2-[18F]FPhe), a promising PET tracer for imaging of cerebral infarction and tumors, was efficiently prepared from an easily accessible iodonium salt precursor using Cu-mediated radiofluorination under ‘low base’ or ‘minimalist’ conditions. Whereas significant racemization was initially observed if the ‘minimalist’ protocol was applied for radiolabeling, it was completely suppressed by the careful adjustment of 18F– preprocessing. The initial biological study revealed a higher uptake of 2-[18F]FPhe in different tumor cells in comparison to that of [18F]FET. In contrast to 4-[18F]FPhe, which suffered from rapid defluorination in vivo, 2-[18F]FPhe demonstrated a sufficient in vivo stability. Conclusively, 2-[18F]FPhe is a promising PET probe that is now readily available using Cu-mediated radiofluorination under ‘minimalist’ or ‘low base’ conditions. The simplicity of the translation of the proposed procedures to automated synthesis modules allows a broad biological evaluation of 2-[18F]FPhe. Notably, a novel protocol for the preparation of N-Boc protected amino acids from the respective Ni-Schiff base complexes was developed that avoided application of strongly acidic conditions.

Tetradentate Schiff Base Complexes of Transition Metals for Antimicrobial Activity

2020 ◽  
Vol 45 (6) ◽  
pp. 4683-4695
Author(s):  
Jagadeesan Saranya ◽  
Suyambulingam Jone Kirubavathy ◽  
Subramanian Chitra ◽  
Abdelkader Zarrouk ◽  
Kulkarni Kalpana ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
Transition Metals ◽  
Schiff Base Complexes ◽  
Tetradentate Schiff Base ◽  
Complexes Of Transition Metals

scholarly journals Synthesis and Characterization of Schiff Base Complexes of o-Vanillin and Anthranilic Acid and Their Biological Evaluation

2018 ◽  
Vol 30 (9) ◽  
pp. 1989-1993 ◽  
Author(s):  
Rajeev Pradhan ◽  
Sumit Kumar Sinha ◽  
Punam Verma ◽  
Sunny Kumar ◽  
Shivadhar Sharma
Keyword(s):  
Schiff Base ◽  
Anthranilic Acid ◽  
Biological Evaluation ◽  
Schiff Base Complexes ◽  
Synthesis And Characterization
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