Multinuclear silver N ‐heterocyclic carbene complexes provoke potent anticancer activity via mitochondrial dysfunction and cell necrosis induction

2021 ◽  
Author(s):  
Weihong Zheng ◽  
Qing Zheng ◽  
Chao Chen ◽  
Hangxiang Wang
Keyword(s):  
Mitochondrial Dysfunction ◽  
Anticancer Activity ◽  
Cell Necrosis ◽  
Carbene Complexes

H2O2 enhances the anticancer activity of TMPyP4 by ROS-mediated mitochondrial dysfunction and DNA damage

2021 ◽  
Vol 38 (6) ◽  
Author(s):  
Jianqiang Chen ◽  
Xiangxiang Jin ◽  
Zhe Shen ◽  
Yanan Mei ◽  
Jufan Zhu ◽  
...  
Keyword(s):  
Dna Damage ◽  
Mitochondrial Dysfunction ◽  
Anticancer Activity

Synthesis, Structure, and Anticancer Activity of Symmetrical and Non-symmetrical Silver(I)-N-Heterocyclic Carbene Complexes

2020 ◽  
Vol 191 (3) ◽  
pp. 1171-1189 ◽  
Author(s):  
Muhammad Atif ◽  
Haq Nawaz Bhatti ◽  
Rosenani A. Haque ◽  
Muhammad Adnan Iqbal ◽  
Mohammad B. Ahamed Khadeer ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Carbene Complexes

Dietary zerumbone from shampoo ginger: new insights into its antioxidant and anticancer activity

2019 ◽  
Vol 10 (3) ◽  
pp. 1629-1642 ◽  
Author(s):  
A. Rosa ◽  
D. Caprioglio ◽  
R. Isola ◽  
M. Nieddu ◽  
G. Appendino ◽  
...  
Keyword(s):  
Mitochondrial Dysfunction ◽  
Lipid Profile ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Total Lipid ◽  
Lipid Droplets

The dietary sesquiterpene dienone zerumbone (ZER) selectively targets cancer cells, inducing mitochondrial dysfunction, apoptosis, modulation of the total lipid profile, and accumulation of cytosolic lipid droplets.

scholarly journals Synthesis and anticancer activity of silver(i)–N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine

2015 ◽  
Vol 44 (16) ◽  
pp. 7563-7569 ◽  
Author(s):  
Heba A. Mohamed ◽  
Benjamin R. M. Lake ◽  
Thomas Laing ◽  
Roger M. Phillips ◽  
Charlotte E. Willans
Keyword(s):  
Anticancer Activity ◽  
Carbene Complexes

Silver–N-heterocyclic carbene complexes derived from natural xanthine products have been prepared. Chemosensitivity studies indicate a correlation between cytotoxicity, ligand sterics and hydrophilicity.

Anthracenyl Functionalization of Half-Sandwich Carbene Complexes: In Vitro Anticancer Activity and Reactions with Biomolecules

2021 ◽  
Vol 60 (19) ◽  
pp. 14636-14644
Author(s):  
Betty Y. T. Lee ◽  
Matthew P. Sullivan ◽  
Ena Yano ◽  
Kelvin K. H. Tong ◽  
Muhammad Hanif ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Carbene Complexes ◽  
Half Sandwich

Synthesis, X-ray structures, spectroscopic analysis and anticancer activity of novel gold(I) carbene complexes

2014 ◽  
Vol 765 ◽  
pp. 68-79 ◽  
Author(s):  
Muhammad Altaf ◽  
M. Monim-ul-Mehboob ◽  
Adam A.A. Seliman ◽  
Anvarhusein A. Isab ◽  
Vikram Dhuna ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Spectroscopic Analysis ◽  
Carbene Complexes ◽  
X Ray

scholarly journals The (+)-Brevipolide H Displays Anticancer Activity against Human Castration-Resistant Prostate Cancer: The Role of Oxidative Stress and Akt/mTOR/p70S6K-Dependent Pathways in G1 Checkpoint Arrest and Apoptosis

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2929
Author(s):  
Yi-Hua Sheng ◽  
Wohn-Jenn Leu ◽  
Ching-Nung Chen ◽  
Jui-Ling Hsu ◽  
Ying-Tung Liu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Mitochondrial Dysfunction ◽  
Anticancer Activity ◽  
Intracellular Signaling ◽  
G1 Phase ◽  
G1 Arrest ◽  
Ros Production ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant

Because conventional chemotherapy is not sufficiently effective against prostate cancer, various examinations have been performed to identify anticancer activity of naturally occurring components and their mechanisms of action. The (+)-brevipolide H, an α-pyrone-based natural compound, induced potent and long-term anticancer effects in human castration-resistant prostate cancer (CRPC) PC-3 cells. Flow cytofluorometric analysis with propidium iodide staining showed (+)-brevipolide H-induced G1 arrest of cell cycle and subsequent apoptosis through induction of caspase cascades. Since Akt/mTOR pathway has been well substantiated in participating in cell cycle progression in G1 phase, its signaling and downstream regulators were examined. Consequently, (+)-brevipolide H inhibited the signaling pathway of Akt/mTOR/p70S6K. The c-Myc inhibition and downregulation of G1 phase cyclins were also attributed to (+)-brevipolide H action. Overexpression of myristoylated Akt significantly rescued mTOR/p70S6K and downstream signaling under (+)-brevipolide H treatment. ROS and Ca2+, two key mediators in regulating intracellular signaling, were determined, showing that (+)-brevipolide H interactively induced ROS production and an increase of intracellular Ca2+ levels. The (+)-Brevipolide H also induced the downregulation of anti-apoptotic Bcl-2 family proteins (Bcl-2 and Bcl-xL) and loss of mitochondrial membrane potential, indicating the contribution of mitochondrial dysfunction to apoptosis. In conclusion, the data suggest that (+)-brevipolide H displays anticancer activity through crosstalk between ROS production and intracellular Ca2+ mobilization. In addition, suppression of Akt/mTOR/p70S6K pathway associated with downregulation of G1 phase cyclins contributes to (+)-brevipolide H-mediated anticancer activity, which ultimately causes mitochondrial dysfunction and cell apoptosis. The data also support the biological significance and, possibly, clinically important development of natural product-based anticancer approaches.

Anticancer Activity of Silver-N-Heterocyclic Carbene Complexes: Caspase-Independent Induction of Apoptosis via Mitochondrial Apoptosis-Inducing Factor (AIF)

ChemMedChem ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. 805-814 ◽  
Author(s):  
Laure Eloy ◽  
Anne-Sophie Jarrousse ◽  
Marie-Laure Teyssot ◽  
Arnaud Gautier ◽  
Laurent Morel ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Mitochondrial Apoptosis ◽  
Carbene Complexes ◽  
Induction Of Apoptosis ◽  
Apoptosis Inducing Factor

scholarly journals Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole

2008 ◽  
Vol 2008 ◽  
pp. 1-7 ◽  
Author(s):  
Doug A. Medvetz ◽  
Khadijah M. Hindi ◽  
Matthew J. Panzner ◽  
Andrew J. Ditto ◽  
Yang H. Yun ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Silver Complexes ◽  
Carbene Complexes ◽  
Human Cancer Cell Lines

A class of Ag(I) N-heterocyclic carbene silver complexes, 1–3, derived from 4,5-dichloro-1H-imidazole has been evaluated for their anticancer activity against the human cancer cell lines OVCAR-3 (ovarian), MB157 (breast), and Hela (cervical). Silver complexes 1–3 are active against the ovarian and breast cancer cell lines. A preliminary in vivo study shows 1 to be active against ovarian cancer in mice. The results obtained in these studies warrant further investigation of these compounds in vivo.

Adjusting the DNA Interaction and Anticancer Activity of Pt(II) N-Heterocyclic Carbene Complexes by Steric Shielding of the Trans Leaving Group

2015 ◽  
Vol 58 (15) ◽  
pp. 6283-6292 ◽  
Author(s):  
Julienne K. Muenzner ◽  
Tobias Rehm ◽  
Bernhard Biersack ◽  
Angela Casini ◽  
Inge A. M. de Graaf ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Dna Interaction ◽  
Carbene Complexes ◽  
Leaving Group
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