Insight on Ni(II) and Cu(II) complexes of biguanide derivatives developed as effective antimicrobial and antitumour agents

2021 ◽  
Author(s):  
Mihaela Badea ◽  
Maria Nicoleta Grecu ◽  
Mariana Carmen Chifiriuc ◽  
Coralia Bleotu ◽  
Marcela Popa ◽  
...  
Keyword(s):  
Antitumour Agents

New designs in cyclophosphazenes as antitumour agents

1980 ◽  
Vol 77 ◽  
pp. 85-89 ◽  
Author(s):  
Jean-François Labarre ◽  
Francois Lahana ◽  
Françoise Sournies ◽  
Suzy Cros ◽  
Georgette François
Keyword(s):  
Antitumour Agents

Plant antitumour agents.

1973 ◽  
Vol 14 (47) ◽  
pp. 4675-4678 ◽  
Author(s):  
M.C. Wani ◽  
H.L. Taylor ◽  
M.E. Wall
Keyword(s):  
Antitumour Agents

Design, synthesis and apoptosis inducing effect of novel (Z)-3-(3′-methoxy-4′-(2-amino-2-oxoethoxy)-benzylidene)indolin-2-ones as potential antitumour agents

2016 ◽  
Vol 118 ◽  
pp. 34-46 ◽  
Author(s):  
Kishna Ram Senwar ◽  
T. Srinivasa Reddy ◽  
Dinesh Thummuri ◽  
Pankaj Sharma ◽  
V.G.M. Naidu ◽  
...  
Keyword(s):  
Design Synthesis ◽  
Antitumour Agents

Induction of apoptosis and/or necrosis following exposure to antitumour agents in a melanoma cell line, probably through modulation of Bcl-2 family proteins

2003 ◽  
Vol 13 (5) ◽  
pp. 457-464 ◽  
Author(s):  
Hirofumi Shibuya ◽  
Yukihiko Kato ◽  
Masuyoshi Saito ◽  
Tamaki Isobe ◽  
Ryoji Tsuboi ◽  
...  
Keyword(s):  
Cell Line ◽  
Melanoma Cell ◽  
Melanoma Cell Line ◽  
Antitumour Agents ◽  
Induction Of Apoptosis

Synthesis of isoquinolines and tetrahydroisoquinolines as potential antitumour agents

Tetrahedron ◽  
2001 ◽  
Vol 57 (39) ◽  
pp. 8297-8303 ◽  
Author(s):  
A.S Capilla ◽  
M Romero ◽  
M.D Pujol ◽  
D.H Caignard ◽  
P Renard
Keyword(s):  
Antitumour Agents

scholarly journals HUMANIZED MICE: CREATION, MODELS AND USE IN EXPERIMENTAL ONCOLOGY (REVIEW)

Biomeditsina ◽  
2019 ◽  
pp. 67-81
Author(s):  
O. I. Kit ◽  
A. Yu. Maksimov ◽  
T. P. Protasova ◽  
A. S. Goncharova ◽  
D. S. Kutilin ◽  
...  
Keyword(s):  
Cancer Biology ◽  
Human Cancer ◽  
Transgenic Animals ◽  
Humanized Mice ◽  
Humanized Mouse ◽  
Antitumour Agents ◽  
Human Genes ◽  
Oncology Review ◽  
Wide Range ◽  
Humanized Mouse Models

Research laboratories in various countries are constantly endeavouring to improve the existing and to create new biological objects to simulate various human diseases. Immunodefi cient mice with transplanted human functional cells and tissues, as well as transgenic animals with the relevant human genes integrated in their genome — i. e. humanized mice — are increasingly used as test systems in biomedical studies. Humanized mouse models are constantly being improved to fi nd application in studies investigating human biological reactions and identifying the pathogenetic mechanisms behind a wide range of diseases, or as preclinical tools for medicine testing. In particular, such animals play an increasingly important role both in studies of human-specifi c infectious agents, cancer biology research and in the development of new antitumour agents. In addition, humanized mice are increasingly used as translational models in many areas of clinical research, including transplantology, immunology and oncology. Ultimately, the use of humanized animals can lead to the introduction of a truly personalized medicine into clinical practice. In this review, we discuss modern advances in the creation and use of humanized mice, emphasizing their usefulness for the pathogenesis study, as well as the development of new methods for human cancer treatment.

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