Preparation and crystallographic studies of a new mercuric salicylaldimine complex for fabrication of microscaled and nanoscaled mercuric sulfide as antimicrobial agents against human pathogenic yeasts and filamentous fungi

2020 ◽  
Author(s):  
Ahmed B.M. Ibrahim ◽  
Ghada Abd‐Elmonsef Mahmoud ◽  
Florian Meurer ◽  
Michael Bodensteiner
Keyword(s):  
Filamentous Fungi ◽  
Antimicrobial Agents ◽  
Mercuric Sulfide

scholarly journals Biosynthesis of Silver Nanoparticles Mediated by Entomopathogenic Fungi: Antimicrobial Resistance, Nanopesticides, and Toxicity

Antibiotics ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 852
Author(s):  
Tárcio S. Santos ◽  
Tarcisio M. Silva ◽  
Juliana C. Cardoso ◽  
Ricardo L. C. de Albuquerque-Júnior ◽  
Aleksandra Zielinska ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Filamentous Fungi ◽  
Entomopathogenic Fungi ◽  
Antimicrobial Agents ◽  
Insect Pests ◽  
Insect Control ◽  
Biological Synthesis ◽  
Biological Methods ◽  
Potential Use

Silver nanoparticles are widely used in the biomedical and agri-food fields due to their versatility. The use of biological methods for the synthesis of silver nanoparticles has increased considerably due to their feasibility and high biocompatibility. In general, microorganisms have been widely explored for the production of silver nanoparticles for several applications. The objective of this work was to evaluate the use of entomopathogenic fungi for the biological synthesis of silver nanoparticles, in comparison to the use of other filamentous fungi, and the possibility of using these nanoparticles as antimicrobial agents and for the control of insect pests. In addition, the in vitro methods commonly used to assess the toxicity of these materials are discussed. Several species of filamentous fungi are known to have the ability to form silver nanoparticles, but few studies have been conducted on the potential of entomopathogenic fungi to produce these materials. The investigation of the toxicity of silver nanoparticles is usually carried out in vitro through cytotoxicity/genotoxicity analyses, using well-established methodologies, such as MTT and comet assays, respectively. The use of silver nanoparticles obtained through entomopathogenic fungi against insects is mainly focused on mosquitoes that transmit diseases to humans, with satisfactory results regarding mortality estimates. Entomopathogenic fungi can be employed in the synthesis of silver nanoparticles for potential use in insect control, but there is a need to expand studies on toxicity so to enable their use also in insect control in agriculture.

Studies on the aerobic deterioration of whole-crop cereal silages

1982 ◽  
Vol 98 (3) ◽  
pp. 529-535 ◽  
Author(s):  
M. K. Woolford ◽  
K. K. Bolsen ◽  
Lesley A. Peartt
Keyword(s):  
Filamentous Fungi ◽  
Butyric Acid ◽  
Dry Matter ◽  
Antimicrobial Agents ◽  
Matter Content ◽  
Dry Matter Content ◽  
Antimicrobial Effects ◽  
High Dry Matter ◽  
Proteolytic Bacteria ◽  
Barley Silage

SUMMARYAs a result of the treatment of made whole-crop barley silage with antimicrobial agents which are specifically inhibitory to fungi or bacteria, it was shown that the subsequent aerobic deterioration was essentially caused by yeasts. These microorganisms were instrumental in the rise in pH, the increase in temperature and the loss of dry matter observed. The filamentous fungi, like one group of bacteria (the streptomycetes), apparently had no part in the process. Bacteria, such as the lactobacilli and particularly proteolytic bacteria, may have had a role in the terminal stages of deterioration, although it was considered more likely that the yeasts again were involved.The whole-crop wheat silage employed in this work was stable in air, a factor attributed to the combined antimicrobial effects of butyric acid present and the relatively high dry-matter content.

scholarly journals Structure and Synthesis of Antifungal Disulfide β-Strand Proteins from Filamentous Fungi

2018 ◽  
Vol 7 (1) ◽  
pp. 5 ◽  
Author(s):  
Györgyi Váradi ◽  
Gábor Tóth ◽  
Gyula Batta
Keyword(s):  
Filamentous Fungi ◽  
Disulfide Bonds ◽  
Antimicrobial Agents ◽  
Tertiary Structure ◽  
Fungal Infections ◽  
Recombinant Expression ◽  
Antifungal Protein ◽  
Significant Group ◽  
Antifungal Proteins ◽  
Neosartorya Fischeri

The discovery and understanding of the mode of action of new antimicrobial agents is extremely urgent, since fungal infections cause 1.5 million deaths annually. Antifungal peptides and proteins represent a significant group of compounds that are able to kill pathogenic fungi. Based on phylogenetic analyses the ascomycetous, cysteine-rich antifungal proteins can be divided into three different groups: Penicillium chrysogenum antifungal protein (PAF), Neosartorya fischeri antifungal protein 2 (NFAP2) and “bubble-proteins” (BP) produced, for example, by P. brevicompactum. They all dominantly have β-strand secondary structures that are stabilized by several disulfide bonds. The PAF group (AFP antifungal protein from Aspergillus giganteus, PAF and PAFB from P. chrysogenum, Neosartorya fischeri antifungal protein (NFAP)) is the best characterized with their common β-barrel tertiary structure. These proteins and variants can efficiently be obtained either from fungi production or by recombinant expression. However, chemical synthesis may be a complementary aid for preparing unusual modifications, e.g., the incorporation of non-coded amino acids, fluorophores, or even unnatural disulfide bonds. Synthetic variants up to ca. 6–7 kDa can also be put to good use for corroborating structure determination. A short overview of the structural peculiarities of antifungal β-strand disulfide bridged proteins will be given. Here, we describe the structural propensities of some known antifungal proteins from filamentous fungi which can also be prepared with modern synthetic chemistry methods.

Essential oil from Zanthoxylum tingoassuiba loaded into multilamellar liposomes useful as antimicrobial agents

2009 ◽  
pp. 1-8 ◽  
Author(s):  
C. B. Detoni ◽  
E. C. M. Cabral-Albuquerque ◽  
S. V. A. Hohlemweger ◽  
C. Sampaio ◽  
T. F. Barros ◽  
...  
Keyword(s):  
Essential Oil ◽  
Antimicrobial Agents ◽  
Multilamellar Liposomes

Anticancer drug discovery from filamentous fungi

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
NH Oberlies ◽  
A Sy ◽  
TN Graf ◽  
DJ Kroll ◽  
Y Nakanishi ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Filamentous Fungi ◽  
Anticancer Drug ◽  
Anticancer Drug Discovery

The search for new antibiotic substances from filamentous fungi

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
KS Svahn ◽  
U Göransson ◽  
A Strömstedt ◽  
H El-Seedi ◽  
L Bohlin ◽  
...  
Keyword(s):  
Filamentous Fungi
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