Biological evaluation, molecular docking, DNA interaction and thermal studies of new bioactive metal complexes of 2‐hydroxybenzaldehyde and fluorobenzamine Schiff base ligand

2020 ◽  
Author(s):  
Kavitha Bengi ◽  
Sravanthi Maddikayala ◽  
Saritha Reddy Pulimamidi
Keyword(s):  
Schiff Base ◽  
Molecular Docking ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Thermal Studies ◽  
Dna Interaction ◽  
Biological Evaluation

scholarly journals Synthesis, Spectroscopic Characterization, and Biological Evaluation Studies of 5-Bromo-3-(((hydroxy-2-methylquinolin-7-yl)methylene)hydrazono)indolin-2-one and Its Metal (II) Complexes

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Kuruba Siddappa ◽  
Nabiya Sultana Mayana
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Stability Constants ◽  
Dna Cleavage ◽  
Thermal Studies ◽  
Mixed Solvents ◽  
Free Ligand ◽  
Biological Evaluation ◽  
Spectral Studies ◽  
Ph Titration

The Schiff base ligand 5-bromo-3-(((8-hydroxy-2-methylquinolin-7-yl)methylene)hydrazono)indolin-2-one (BHMQMHI) was preparedviacondensation of 5-bromo-3-hydrazonoindolin-2-one and 7-formyl-8-hydroxy-2-methylquinoline and its Co(II), Ni(II), Cu(II), Zn(II), Cd(II), and Hg(II) complexes have been synthesized and characterized by elemental analysis, conductance data, magnetic susceptibility measurements, IR, UV-Vis, mass spectrometry,1H NMR, ESR, XRD, and thermal studies. By these spectral studies it is found that Co(II), Ni(II), and Cu(II) complexes have exhibited octahedral geometry whereas the Zn(II), Cd(II), and Hg(II) complexes have exhibited tetrahedral geometry. Potentiometric studies have been carried out on complexes of Schiff base (BHMQMHI) with Cu(II), Co(II), and Ni(II). Calvin-Bjerrum pH-titration technique as used by Irving and Rossotti has been applied to determine stability constants in mixed solvents at25 ± 1°C. The present study reports the protonation constants of this ligand and stability constants of its metal complexes in dioxane-water (50%, v/v) mixtures. Metal-ligand stability constants fall in the order of Cu(II) > Co(II) > Ni(II) which is in agreement with those reported by Irving stability order. The Schiff base (BHMQMHI) and its metal complexes have been screened for theirin vitroantibacterial and antifungal activities by minimum inhibitory concentration (MIC) method. The DNA cleavage activities of all the complexes were studied by agarose gel electrophoresis method. In addition, the free ligand along with its complexes has been studied for their antioxidant activity.

scholarly journals Cobalt (II) and Nickel (II) Complexes with Schiff Base Ligand Derived From 4-Amino Antipyrine: Synthesis, Spectral, Characterization and Thermal Studies

2018 ◽  
Vol 7 (4.37) ◽  
pp. 198
Author(s):  
Ahmed Razzaq Ibrahim Al-Faris ◽  
Wafaa Mahdi Sachit Alkoofee ◽  
. .
Keyword(s):  
Schiff Base ◽  
Melting Point ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Thermal Studies ◽  
Molar Conductance ◽  
Conductance Data ◽  
Elemental Analyses ◽  
Uv Visible ◽  
Chloride Salts

Metal complexes of the Schiff base ligand, synthesized via condensation p-dimethylamino benzaldehyde with Bis (4-aminoantipyrine) benzene 1, 4-diamine which has synthesized from condensation 1, 4-phenylene diamine and 4-aminoantipyrine, are synthesized from chloride salts of Co (II) and Ni(II) with ligand in ethanol. The metal complexes and ligand are characterized on the basis of elemental analyses, melting point, molar conductance, UV –Visible, FTIR and thermogravimetric analysis. The molar conductance data reveal that the metal chelates of the ligand with Co (II) and Ni (II) are electrolytes. The present results suggested that the Schiff base ligand as tetradentate is coordinated with metal ions through the four nitrogen atoms. 

scholarly journals Synthesis, Characterization and Biological Evaluation of New Schiff Base Ligand derived from 3-hydroxy-benzaldehyde and p-toluidine and its Divalent Metal Ions

2020 ◽  
Vol 71 (4) ◽  
pp. 47-58
Author(s):  
Noreen Mazhar ◽  
Mehwish Aftab ◽  
Tariq Mahmud ◽  
Muhammadasim Raza Basra ◽  
Mansoor Akhtar ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Protein Denaturation ◽  
Condensation Reaction ◽  
Free Ligand ◽  
Biological Evaluation ◽  
Divalent Metal ◽  
Anti Inflammatory

A new Schiff base ligand (L) and its transition divalent metal complexes were prepared by the condensation reaction; Reaction was carried out at 70-80 oC by refluxing equimolar ratio of toluidine and aldehyde by continuous stirring for 5-6 hours. Synthesized ligand and Ni(II), Fe(II), Co(II), Mn(II) and Zn(II) bimetallic complexes were characterized by using FT-IR, UV-visible spectroscopy, AAS, Single crystal X-ray analysis, 1H-NMR, molar conductance. Compounds were screened against two fungus Candida glabrata and Candida albicans by agar tube dilution protocol. In vivo anti-inflammatory activity via induced paw edema method and in vitro results by heat induced protein denaturation method were checked. Synthesized compounds were also showed antioxidant activity by using DPPH (diphenylpicrylhydrazyl) and Trolox was used as standard. These studies show that ligand and almost all metal complexes are reactive towards biological assays against reported standard drugs. Zn-L indicates more activeness for antioxidant activity and free ligand while Co-L recognized as more effective anti-inflammatory drug.

scholarly journals Molecular Docking, DFT Calculations, Effect of High Energetic Ionizing Radiation, and Biological Evaluation of Some Novel Metal (II) Heteroleptic Complexes Bearing the Thiosemicarbazone Ligand

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5851
Author(s):  
Ehab M. Abdalla ◽  
Safaa S. Hassan ◽  
Hussein H. Elganzory ◽  
Samar A. Aly ◽  
Heba Alshater
Keyword(s):  
Molecular Docking ◽  
Metal Complexes ◽  
Density Functional ◽  
Thermal Studies ◽  
Antimicrobial Activities ◽  
Biological Evaluation ◽  
In Vitro Cytotoxicity ◽  
Γ Irradiation ◽  
Before And After

New Pb(II), Mn(II), Hg(II), and Zn(II) complexes, derived from 4-(4-chlorophenyl)-1-(2-(phenylamino)acetyl)thiosemicarbazone, were synthesized. The compounds with general formulas, [Pb(H2L)2(OAc)2]ETOH.H2O, [Mn(H2L)(HL)]Cl, [Hg2(H2L)(OH)SO4], and [Zn(H2L)(HL)]Cl, were characterized by physicochemical and theoretical studies. X-ray diffraction studies showed a decrease in the crystalline size of compounds that were exposed to gamma irradiation (γ-irradiation). Thermal studies of the synthesized complexes showed thermal stability of the Mn(II) and Pb(II) complexes after γ-irradiation compared to those before γ–irradiation, while no changes in the Zn(II) and Hg(II) complexes were observed. The optimized geometric structures of the ligand and metal complexes are discussed regarding density functional theory calculations (DFT). The antimicrobial activities of the ligand and metal complexes against several bacterial and fungal stains were screened before and after irradiation. The Hg(II) complex has shown excellent antibacterial activity before and after γ-irradiation. In vitro cytotoxicity screening of the ligand and the Mn(II) and Zn(II) complexes before and after γ-irradiation disclosed that both the ligand and Mn(II) complex exhibited higher activity against human liver (Hep-G2) than Zn(II). Molecular docking was performed on the active site of MK-2 and showed good results.

Sign in / Sign up

Export Citation Format

Share Document