Isoxazole derivatives of silatrane: synthesis, characterization, in silico ADME profile, prediction of potential pharmacological activity and evaluation of antimicrobial action

2020 ◽  
Vol 34 (12) ◽  
Author(s):  
Sergey N. Adamovich ◽  
Evgeniy V. Kondrashov ◽  
Igor A. Ushakov ◽  
Nina S. Shatokhina ◽  
Elizaveta N. Oborina ◽  
...  
Keyword(s):  
Pharmacological Activity ◽  
In Silico ◽  
Antimicrobial Action ◽  
Adme Profile ◽  
Derivatives Of ◽  
Isoxazole Derivatives

Synthesis and pharmacological activity of derivatives of quinoline and condensed quinolines

1978 ◽  
Vol 12 (7) ◽  
pp. 881-886 ◽  
Author(s):  
V. G. Granik ◽  
A. M. Zhidkova ◽  
S. S. Kiselev ◽  
R. G. Glushkov ◽  
A. I. Polezhaeva ◽  
...  
Keyword(s):  
Pharmacological Activity ◽  
Derivatives Of

Synthesis and pharmacological activity of some derivatives of 3, 5?-BI-1H-indole

1979 ◽  
Vol 13 (4) ◽  
pp. 385-389
Author(s):  
L. G. Chilikin ◽  
N. V. Gorelova ◽  
G. Ya. Shvarts ◽  
N. N. Suvorov
Keyword(s):  
Pharmacological Activity ◽  
Derivatives Of

Synthesis and Pharmacological Activity of Urea and Thiourea Derivatives of 4-Azatricyclo[5.2.2.02,6]undec-8-ene-3,5-dione.

ChemInform ◽  
2007 ◽  
Vol 38 (45) ◽  
Author(s):  
Marta Struga ◽  
Jerzy Kossakowski ◽  
Ewa Kedzierska ◽  
Sylwia Fidecka ◽  
Joanna Stefanska
Keyword(s):  
Pharmacological Activity ◽  
Thiourea Derivatives ◽  
Derivatives Of

Derivatives of the alkaloid convolvine and their pharmacological activity

2011 ◽  
Vol 47 (4) ◽  
pp. 608-611 ◽  
Author(s):  
A. M. Gapparov ◽  
I. I. Okhunov ◽  
S. F. Aripova ◽  
A. Nabiev ◽  
V. U. Khuzhaev
Keyword(s):  
Pharmacological Activity ◽  
Derivatives Of

Synthesis and pharmacological activity of derivatives of 1-(3-amino-2-hydroxypropyl)-5-methoxyindole

1988 ◽  
Vol 22 (8) ◽  
pp. 631-633
Author(s):  
E. K. Panisheva ◽  
T. K. Trubitsina ◽  
A. A. Cherkasova
Keyword(s):  
Pharmacological Activity ◽  
Derivatives Of

scholarly journals Screening of Chloroquine, Hydroxychloroquine and Its Derivatives for Their Binding Affinity to Multiple SARS-CoV-2 Protein Drug Targets

2020 ◽  
Author(s):  
Mallikarjuna Nimgampalle ◽  
Vasudharani Devanthan ◽  
Ambrish Saxena
Keyword(s):  
Binding Affinity ◽  
In Silico ◽  
Drug Targets ◽  
Therapeutic Potential ◽  
Viral Proteins ◽  
Protein Drug ◽  
Potential Treatment ◽  
Health Authorities ◽  
Derivatives Of

Recently Chloroquine and its derivative Hydroxychloroquine have garnered enormous interest amongst the clinicians and health authorities’ world over as a potential treatment to contain COVID-19 pandemic. The present research aims at investigating the therapeutic potential of Chloroquine and its potent derivative Hydroxychloroquine against SARS-CoV-2 viral proteins. At the same time we have screened some chemically synthesized derivatives of Chloroquine and compared their binding efficacy with chemically synthesized Chloroquine derivatives through <i>in silico</i>approaches. For the purpose of the study, we have selected some essential viral proteins and enzymes implicated in SARS-CoV-2 replication and multiplication as putative drug targets.<br>

scholarly journals Synthesis and Prognosis of Anti-inflammatory Activity of 2-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3h)-one

2021 ◽  
Vol 7 (12) ◽  
pp. 25-33
Author(s):  
A. Chiriapkin ◽  
I. Kodonidi ◽  
A. Ivchenko ◽  
L. Smirnova
Keyword(s):  
Acetic Acid ◽  
Biological Activity ◽  
Dimethyl Sulfoxide ◽  
In Silico ◽  
Glacial Acetic Acid ◽  
Inflammatory Activity ◽  
Modified Method ◽  
Anti Inflammatory ◽  
Catalytic Addition ◽  
Derivatives Of

The article presents a modified method for the synthesis of 2-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3H)-one and the predict of their anti-inflammatory activity. The proposed method for obtaining tetrahydrothienopyrimidine derivatives is preparatively effective and simple. Their synthesis was carried out by heterocyclization of azomethine derivatives of 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide in the medium of glacial acetic acid with the catalytic addition of dimethyl sulfoxide. Preliminary prognosis of anti-inflammatory activity in silico method allowed us to identify the most promising compounds. Of these, the 4b structure containing a 2-hydroxyphenyl fragment in the second position of pyrimidine-4(3H)-one may be of the greatest interest. It seems appropriate to further study the spectrum of biological activity of the studied compounds.

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