Harmless glucose‐modified ruthenium complexes suppressing cell migration of highly invasive cancer cell lines

2019 ◽  
Vol 34 (1) ◽  
Author(s):  
Martin Lamač ◽  
Michal Horáček ◽  
Lucie Červenková Šťastná ◽  
Jindřich Karban ◽  
Lucia Sommerová ◽  
...  
Keyword(s):  
Cell Migration ◽  
Cell Lines ◽  
Cancer Cell ◽  
Ruthenium Complexes ◽  
Cancer Cell Lines ◽  
Invasive Cancer ◽  
Invasive Cancer Cell

scholarly journals Potent Cytotoxicity of Four Cameroonian Plant Extracts on Different Cancer Cell Lines

2020 ◽  
Vol 13 (11) ◽  
pp. 357
Author(s):  
Ahmed Somaida ◽  
Imran Tariq ◽  
Ghazala Ambreen ◽  
Ahmed Mohamed Abdelsalam ◽  
Abdallah Mohamed Ayoub ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Migration ◽  
Cell Lines ◽  
Cancer Cell ◽  
Plant Extracts ◽  
Caspase 3 ◽  
Cancer Cell Lines ◽  
Imperata Cylindrica ◽  
Tumor Cell Death ◽  
Genetic Toxicity

In this study, the potential cytotoxicity of four plant extracts originated from Cameroon: Xylopia aethiopica (XA), Imperata cylindrica (IC), Echinops giganteus (EG) and Dorstenia psilurus (DP) were examined in vitro. We tested the anti-proliferative activity of the methanolic extracts of these compounds using MTT assay on seven different human cancer cell lines: HeLa, MDA-MB-231, A549, HepG2, U-87, SK-OV-3 and HL60. Induction of cell death was assessed by cell cycle analysis, apoptosis was determined by Annexin V-FITC binding and caspase 3/7 activity. As well, changes in mitochondrial membrane potential (MMP) and cell migration were tested. The genetic toxicity, using the alkaline comet assay, was evaluated. The studied extracts inhibited the cell proliferation of all tested cancer cell lines with concentration dependent effect over time. All of these extracts mainly induced apoptosis of HeLa cells by the accumulation of hypodiploid cells in the sub-G0/G1 phase and increasing the activity of caspase 3/7, as well they showed potential MMP disturbance and expressed a marked inhibitory effect on cell migration. Assessment of probable genetic toxicity by these extracts revealed no or minimum incidence of genetic toxicity. Therefore, the studied plant extracts are exhibiting potent anticancer activity based upon marked induction of tumor-cell death.

LncRNA SNHG1 enhances cell proliferation, migration, and invasion in cervical cancer

2018 ◽  
Vol 96 (1) ◽  
pp. 38-43 ◽  
Author(s):  
Yang Liu ◽  
Yanling Yang ◽  
Lei Li ◽  
Yuan Liu ◽  
Peng Geng ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Proliferation ◽  
Cell Migration ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Cervical Cancer Cell ◽  
Knock Down ◽  
Cervical Cancer Cells

Objective: This study investigated the effects of lncRNA SNHG1 on the proliferation, migration, and invasiveness of cervical cancer cells. Methods: Three pairs of cervical cancer tissue samples and their corresponding adjacent samples were analyzed using Human LncRNA Microarray V3.0 chip for differential analysis. The expression of SNHG1 in cervical cancer cell lines was verified by qRT–PCR. CCK8 assays and colony formation assays were used to study the changes in cell proliferation. Cell migration and Transwell assays were used to study changes in cell migration and invasiveness. Results: SNHG1 was highly expressed in cervical cancer tissues and cervical cancer cell lines. SNHG1 siRNA could knock-down the expression level of SNHG1 in cervical cancer cell lines HeLa and C33-A. After knock-down of SNHG1, cell proliferation and migration as well as invasiveness in HeLa and C-33A cells decreased. Conclusion: LncRNA SNHG1 promotes the development of cervical cancer cells.

scholarly journals Effects of Resveratrol in Cell Migration and Invasion by Studying the CXCR4‐CXCL12 axis in Breast Cancer Cell Lines

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Gerardo Antonio Arroyo‐Martinez ◽  
Maria Figueroa ◽  
Kevin Muñoz‐Forti ◽  
Geralin Trossi ◽  
Jose Robles ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Migration And Invasion ◽  
Breast Cancer Cell Lines ◽  
Cell Migration And Invasion

scholarly journals Increased cell migration and plasticity in Nrf2-deficient cancer cell lines

Oncogene ◽  
2010 ◽  
Vol 29 (25) ◽  
pp. 3703-3714 ◽  
Author(s):  
G Rachakonda ◽  
K R Sekhar ◽  
D Jowhar ◽  
P C Samson ◽  
J P Wikswo ◽  
...  
Keyword(s):  
Cell Migration ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines
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