Spectroscopic and electrochemical study for evaluating DNA interaction activity of 4‐(3‐halophenyl)‐6‐(pyridin‐2‐yl)pyrimidin‐2‐amine based piano stool Cp* Rh (III) and Ir (III) complexes

2019 ◽  
Vol 33 (10) ◽  
Author(s):  
Pankajkumar A. Vekariya ◽  
Parag S. Karia ◽  
Bhupesh S. Bhatt ◽  
Mohan N. Patel
Keyword(s):  
Dna Interaction ◽  
Electrochemical Study

Electrochemical Study of Naringenin-DNA Interaction on Modified DNA-PAH-MPA Gold Electrode

2017 ◽  
Vol 15 (6) ◽  
pp. 492-497 ◽  
Author(s):  
Ferdaous Maâtouk ◽  
MounaMaâtouk ◽  
Houcine Barhoumi ◽  
Nicole Jaffrezic
Keyword(s):  
Gold Electrode ◽  
Dna Interaction ◽  
Electrochemical Study ◽  
Modified Dna

An electrochemical study of neutral red–DNA interaction

2005 ◽  
Vol 51 (6) ◽  
pp. 1108-1116 ◽  
Author(s):  
H. Heli ◽  
S.Z. Bathaie ◽  
M.F. Mousavi
Keyword(s):  
Dna Interaction ◽  
Neutral Red ◽  
Electrochemical Study

Protamine-DNA interaction

1978 ◽  
Vol 36 (2) ◽  
pp. 200-201
Author(s):  
D.P. Bazett-Jones ◽  
F.P. Ottensmeyer
Keyword(s):  
Small Volume ◽  
Double Helix ◽  
Dna Interaction ◽  
Dark Field ◽  
Sperm Head ◽  
Nuclear Proteins ◽  
Field Electron Microscopy ◽  
Dark Field Electron ◽  
Dna Double Helix ◽  
Positively Charged

Dark field electron microscopy has been used for the study of the structure of individual macromolecules with a resolution to at least the 5Å level. The use of this technique has been extended to the investigation of structure of interacting molecules, particularly the interaction between DNA and fish protamine, a class of basic nuclear proteins of molecular weight 4,000 daltons.Protamine, which is synthesized during spermatogenesis, binds to chromatin, displaces the somatic histones and wraps up the DNA to fit into the small volume of the sperm head. It has been proposed that protamine, existing as an extended polypeptide, winds around the minor groove of the DNA double helix, with protamine's positively-charged arginines lining up with the negatively-charged phosphates of DNA. However, viewing protamine as an extended protein is inconsistent with the results obtained in our laboratory.

Computational and Experimental Binding Mechanism of DNA-drug Interactions

2019 ◽  
Vol 24 (32) ◽  
pp. 3739-3757 ◽  
Author(s):  
Chandrabose Selvaraj ◽  
Sanjeev K. Singh
Keyword(s):  
Small Molecules ◽  
Self Assembly ◽  
Genetic Material ◽  
Dna Interaction ◽  
Significant Feature ◽  
Drug Molecules ◽  
Potential Applications ◽  
Novel Drug ◽  
Groove Binders ◽  
Molecular Docking And Dynamics

Nucleic acid is the key unit and a predominant genetic material for interpreting the fundamental basis of genetic information in an organism and now it is used for the evolution of a novel group of therapeutics. To identify the potential impact on the biological science, it receives high recognition in therapeutic applications. Due to its selective recognition of molecular targets and pathways, DNA significantly imparts tremendous specificity of action. Examining the properties of DNA holds numerous advantages in assembly, interconnects, computational elements, along with potential applications of DNA self-assembly and scaffolding include nanoelectronics, biosensors, and programmable/autonomous molecular machines. The interaction of low molecular weight, small molecules with DNA is a significant feature in pharmacology. Based on the mode of binding mechanisms, small molecules are categorized as intercalators and groove binders having a significant role in target-based drug development. The understanding mechanism of drug-DNA interaction plays an important role in the development of novel drug molecules with more effective and lesser side effects. This article attempts to outline those interactions of drug-DNA with both experimental and computational advances, including ultraviolet (UV) -visible spectroscopy, fluorescent spectroscopy, circular dichroism, nuclear magnetic resonance (NMR), molecular docking and dynamics, and quantum mechanical applications.

Impact of the donor substituent on the optoelectrochemical properties of 6H-indolo[2,3-b]quinoxaline amine derivatives

2019 ◽  
Vol 43 (48) ◽  
pp. 19379-19396 ◽  
Author(s):  
Pooja S. Singh ◽  
Purav M. Badani ◽  
Rajesh M. Kamble
Keyword(s):  
Electrochemical Study ◽  
Donor Substituent

An opto-electrochemical study of D–A based indolo-quinoxaline amine derivatives was performed by varying the strength of the amine substituent.

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