Structure‐cytotoxicity relationship for apoptotic inducers organotin(IV) derivatives of mandelic acid and L‐proline and their mixed ligand complexes having enhanced cytotoxicity

2018 ◽  
pp. e4663 ◽  
Author(s):  
Mala Nath ◽  
Partha Roy ◽  
Rutusmita Mishra ◽  
Mridula Thakur
Keyword(s):  
Mandelic Acid ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Derivatives Of

scholarly journals Silver derivatives of multi-donor heterocyclic thioamides as antimicrobial/anticancer agents: unusual bio-activity against methicillin resistantS. aureus,S. epidermidis, andE. faecalisand human bone cancerMG63cell line

RSC Advances ◽  
2019 ◽  
Vol 9 (27) ◽  
pp. 15470-15487 ◽  
Author(s):  
Jaspreet K. Aulakh ◽  
Tarlok S. Lobana ◽  
Henna Sood ◽  
Daljit S. Arora ◽  
Raminderjit Kaur ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Anticancer Agents ◽  
Mixed Ligand ◽  
Human Bone ◽  
Mixed Ligand Complexes ◽  
Line P ◽  
Derivatives Of ◽  
Heterocyclic Thioamides

A series of biosafe mixed-ligand complexes of silver with heterocyclic thioamides have been studied for their antimicrobial/anticancer activity.

Fully Fluorinated Alkoxides. Part VI. Derivatives of Hydroxyhexafluoroisobutyric Acid

1972 ◽  
Vol 50 (6) ◽  
pp. 939-945 ◽  
Author(s):  
J. T. Price ◽  
A. J. Tomlinson ◽  
C. J. Willis
Keyword(s):  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Tridentate Ligand ◽  
Phosphorus Containing ◽  
Fluorinated Alkoxides ◽  
Derivatives Of ◽  
Spectrochemical Series

Hydroxyhexafluoroisobutyric acid, HOC(CF3)2COOH, H2(HHIB), gives complexes with a variety of metals, acting as a chelating, dinegative ligand. Derivatives prepared include [B(HHIB)2]−, [M(HHIB)2]2− (M = Ni, Cu, Co), [M(HHIB)3]3− (M = Al, Cr, Mn, Fe), and mixed ligand complexes of Cu and Ni with HHIB and nitrogen- or phosphorus-containing ligands. In some cases, the HHIB anion appears to act as a tridentate ligand through carboxylate bridging. HHIB is close to water in the spectrochemical series.

Synthesis and Spectroscopic, Thermal and Electrochemical Studies of Mixed-ligand Complexes of Silver(I) with Derivatives of Benzoyltrifluoroacetonate and 4,4ʹ-Bipyridine, Including the Crystal Structure of [Ag(4,4ʹ-bpy)(tfcpb)]n

2012 ◽  
Vol 67 (5) ◽  
pp. 465-472 ◽  
Author(s):  
Farzin Marandi ◽  
Afsaneh Marandi ◽  
Ingo Pantenburg ◽  
Gerd Meyer
Keyword(s):  
Crystal Structure ◽  
Nmr Spectroscopy ◽  
Weak Interactions ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Electrochemical Studies ◽  
One Dimensional ◽  
H Nmr ◽  
Elemental Analyses ◽  
Derivatives Of

Three new mixed-ligand complexes of silver(I) with 4,4ʹ-bipyridine and derivates of benzoyltrifluoroacetone (Htfpb: 4,4,4-trifluoro-1-phenyl-1,3-butandione, Htfcpb: 4,4,4-trifluoro-1-(4- chlorophenyl)-1,3-butandione and Htfmpb: 4,4,4-trifluoro-1-(4-methoxyphenyl)-1,3-butandione) were synthesized and characterized by elemental analyses and 1H NMR spectroscopy. Thermal and electrochemical properties were also studied. The single-crystal structure of [Ag(4,4ʹ-bpy)(tfcpb)]n shows a one-dimensional coordination polymer as a result of 4,4ʹ-bpy bridging. The four-coordinate Ag(I) ions are linked into double chains by Ag...O contacts, which are extended into a 3D supramolecular structure through abundant weak interactions, such as μ...μ, C-H...F, C-H...O, C-H...Cl and F...F contacts.

scholarly journals Synthesis and characterisation of some mixed ligand complexes of thallium (i) metal with isonitrosoethylmethyl ketone

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Kumari Seema ◽  
◽  
Rajneesh Kumar ◽  
Keyword(s):  
Complex Formation ◽  
General Formula ◽  
Mixed Ligand Complex ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Aminobenzoic Acid ◽  
Ligand Complex ◽  
Ambidentate Ligand ◽  
Derivatives Of

The present investigation has been undertaken to examine complex formation by thallium (I) derivatives of 2-nitro phenol (ONP), 2,4-dinitrophenol (DNP), 2,4,6-trinitrophenol (TNP), 1-nitroso-2-naphthol (1N2N), 8-hydroxyquinoline (8HQ), and 2-aminobenzoic acid (OABA) with Isonitrosoethylmethyl Ketone. They have general formula [ML (HL′)], where M = Tl (I), L = deprotonated ONP, DNP, TNP, 8-HQ, 1N2N and OABA and L′ = Isonitrosoethylmethyl Ketone. Isonitrosoethylmethyl Ketone is ambidentate ligand and can donate through oxygen or nitrogen or both. The preparation of mixed ligand complex with the thallium (I) salt of 2,4-dinitrophenol and 2,4,6-trinitrophenol with the Isonitrosoethylmethyl Ketone (INEMK) have very low yield.

Mixed ligand-metal Complexes of 2-(butan-2-ylidene) hydrazinecarbothioamide- Synthesis, Characterization, Computer Aided Drug Character Evaluation and in vitro Biological Activity Assessment

2019 ◽  
Vol 15 ◽  
Author(s):  
Tahmeena Khan ◽  
Rumana Ahmad ◽  
Iqbal Azad ◽  
Saman Raza ◽  
Seema Joshi ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Metal Complexes ◽  
Condensation Reaction ◽  
Dose Range ◽  
Biological Significance ◽  
Mixed Ligand ◽  
Binding Energies ◽  
Mixed Ligand Complexes ◽  
E Coli ◽  
Topo Ii

Background: Mixed ligand-metal complexes are efficient chelating agents because of flexible donor ability. Mixed ligand complexes containing hetero atoms sulphur, nitrogen and oxygen have been probed for their biological significance. Objective: Nine mixed ligand-metal complexes of 2-(butan-2-ylidene) hydrazinecarbothioamide (2-butanone thiosemicarbazone) and pyridine, bipyridine or 2-picoline as co-ligands were synthesized with Cu, Fe and Zn. The complexes were tested against MDA-MB231 (MDA) and A549 cell lines. Antibacterial activity was tested against S. aureus and E. coli. The drug character of the complexes was evaluated on several parameters viz. physicochemical properties, bioactivity scores, toxicity assessment and absorption, distribution, metabolism, excretion and toxicity (ADMET) profile assessment using various automated softwares. Molecular docking of the complexes was also performed with two target proteins. Method and Results: The mixed ligand-metal complexes were synthesized by condensation reaction for 4-5 h. The characterization was done by elemental analysis, 1H-NMR, FT-IR, molar conductance and UV spectroscopies. Molecular docking was performed against ribonucleotide reductase (RR) and topoisomerase II (topo II). [Cu(C5H11N3S)(py)2(CH3COO)2], [Zn(C5H11N3S)(bpy)(SO4)] and [Zn(C5H11N3S)(2-pic)2(SO4)] displayed the lowest binding energies with respect to RR. Against topo II [Cu(C5H11N3S)(py)2(CH3COO)2], [Cu(C5H11N3S)(bpy)(CH3COO)2] and [Zn(C5H11N3S)(2-pic)2(SO4)] had the lowest energies. The druglikness assessment was done using Leadlikeness and Lipinski’s rules. Against topo II [Cu(C5H11N3S)(py)2(CH3COO)2], [Cu(C5H11N3S)(bpy)(CH3COO)2] and [Zn(C5H11N3S)(2-pic)2(SO4)] had the lowest energies. Not more than two violations were obtained in case of each filtering rule showing drug like character of the mixed ligand complexes. Several of the complexes exhibited positive bioactivity scores and almost all the complexes were predicted to be safe with no hazardous effects. All the complexes were predicted to have no mutagenic character as shown by the Ames test [Zn(C5H11N3S)(py)2(SO4)] showed potential activity against MDA. [Co(C5H11N3S(bpy)(Cl)2] was also active against MDA. [Cu(C5H11N3S)(2-pic)2(CH3COO)2] also showed 27.6% cell viability at 100 µM against MDA. Against A549 [Co(C5H11N3S)(py)2(Cl)2], [Cu(C5H11N3S)(py)2(CH3COO)2] and [Co(C5H11N3S(bpy)(Cl)2] were active. [Co(C5H11N3S)(bpy)(Cl)2] and [Cu(C5H11N3S)(2-pic)2(CH3COO)2] were active against S. aureus. [Co(C5H11N3S)(2-pic)2(Cl)2] and [Zn(C5H11N3S)(2-pic)2(SO4)] were active at lower concentrations against S.aureus. Against E. coli, [Zn(C5H11N3S)(2-pic)2(SO4)] showed activity at 18-20mg dose range.

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