Chemoselective hydrogenation of nitriles to primary amines catalyzed by water-soluble transition metal catalysts

2018 ◽  
Vol 32 (9) ◽  
pp. e4481 ◽  
Author(s):  
Abdelaziz Nait Ajjou ◽  
André Robichaud
Keyword(s):  
Transition Metal ◽  
Metal Catalysts ◽  
Transition Metal Catalysts ◽  
Water Soluble ◽  
Primary Amines ◽  
Chemoselective Hydrogenation ◽  
Hydrogenation Of Nitriles

scholarly journals Selective Heterogeneous Catalytic Hydrogenation of Nitriles to Primary Amines

2018 ◽  
Vol 62 (4) ◽  
Author(s):  
Krisztina Lévay ◽  
László Hegedűs
Keyword(s):  
Transition Metal ◽  
Catalytic Hydrogenation ◽  
Reaction Pathway ◽  
Selective Reduction ◽  
Metal Catalysts ◽  
Transition Metal Catalysts ◽  
Primary Amines ◽  
Heterogeneous Catalytic ◽  
Hydrogenation Of Nitriles ◽  
Heterogeneous Catalytic Hydrogenation

Primary amines are important intermediates, especially in the area of pharmaceutical, plastic and agrochemical industry. The heterogeneous catalytic hydrogenation of nitriles is one of the most frequently applied process for the synthesis of diverse amines. However, the control of the selectivity is a critical issue in this reaction. Over the past decade, many studies have been reported using heterogeneous transition metal catalysts for the selective reduction of nitriles to the corresponding primary amines. The type of the catalysts, especially, the chemical nature of metals in the catalysts is one of the most important factors to influence the selectivity, the reaction rate, and possibly also the reaction pathway and the deactivation of the catalyst. Thus, this review focuses on the heterogeneous transition metal catalysts and summarizes the recent developments achieved in the selective catalytic hydrogenation of nitriles to primary amines.

Recent Achievements in the Hydrogenation of Nitriles Catalyzed by Transitional Metals

2019 ◽  
Vol 23 (18) ◽  
pp. 1881-1900 ◽  
Author(s):  
Krisztina Lévay ◽  
László Hegedűs
Keyword(s):  
Transition Metal ◽  
Homogeneous Catalysis ◽  
Catalytic Hydrogenation ◽  
Selective Reduction ◽  
Metal Catalysts ◽  
Transition Metal Catalysts ◽  
Transitional Metals ◽  
Heterogeneous Catalytic ◽  
Hydrogenation Of Nitriles ◽  
Heterogeneous Catalytic Hydrogenation

Amines are important and valuable intermediates in the pharmaceutical, plastic and agrochemical industry. Hence, there is an increasing interest in developing improved process for the synthesis of amines. The heterogeneous catalytic hydrogenation of nitriles is one of the most frequently applied methods for the synthesis of diverse amines, but the homogeneous catalysis has also received a growing attention from the catalysis community. This mini-review provides an overview of the recent achievements in the selective reduction of nitriles using both homogeneous and heterogeneous transition metal catalysts.

Sulfur-Mediated Reactions through Sulfonium Salts and Ylides

Synlett ◽  
2021 ◽  
Author(s):  
Pingfan Li
Keyword(s):  
Transition Metal ◽  
Rational Design ◽  
Acid Catalysis ◽  
Metal Catalysts ◽  
Transition Metal Catalysts ◽  
Bronsted Acid ◽  
Proof Of Concept ◽  
Sulfonium Salts ◽  
Brönsted Acid ◽  
Sulfonium Ylides

AbstractThis Account discusses several new reaction methods developed in our group that utilize sulfur-mediated reactions through sulfonium salts and ylides, highlighting the interplay of rational design and serendipity. Our initial goal was to convert aliphatic C–H bonds into C–C bonds site-selectively, and without the use of transition-metal catalysts. While a proof-of-concept has been achieved, this target is far from being ideally realized. The unexpected discovery of an anti-Markovnikov rearrangement and subsequent studies on difunctionalization of alkynes were much more straightforward, and eventually led to the new possibility of asymmetric N–H insertion of sulfonium ylides through Brønsted acid catalysis.1 Introduction2 Allylic/Propargylic C–H Functionalization3 Anti-Markovnikov Rearrangement4 Difunctionalization of Alkynes5 Asymmetric N–H Insertion of Sulfonium Ylides6 Conclusion

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