Spectroscopic, thermal, biological activity, molecular docking and density functional theoretical investigation of novel bis Schiff base complexes

2018 ◽  
Vol 32 (7) ◽  
pp. e4375 ◽  
Author(s):  
Ehab M. Zayed ◽  
Gehad G. Mohamed ◽  
Walid M.I. Hassan ◽  
Asmaa K. Elkholy ◽  
H. Moustafa
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Molecular Docking ◽  
Theoretical Investigation ◽  
Density Functional ◽  
Schiff Base Complexes

Synthesis, Spectroscopic, Biological Activity, Molecular Docking and Density Functional Theoretical Investigations of Novel Tellurium(IV) Schiff Base Complexes

2021 ◽  
Vol 6 (23) ◽  
pp. 5778-5790
Author(s):  
Manish Kumar ◽  
Poonam Jangra Darolia ◽  
Sonu Chauhan ◽  
Meena Sindhu ◽  
K. K. Verma ◽  
...  
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Molecular Docking ◽  
Density Functional ◽  
Schiff Base Complexes ◽  
Theoretical Investigations

scholarly journals Utilization and simulation of innovative new binuclear Co(ii), Ni(ii), Cu(ii), and Zn(ii) diimine Schiff base complexes in sterilization and coronavirus resistance (Covid-19)

2021 ◽  
Vol 19 (1) ◽  
pp. 772-784
Author(s):  
Moamen S. Refat ◽  
Ahmed Gaber ◽  
Walaa F. Alsanie ◽  
Mohamed I. Kobeasy ◽  
Rozan Zakaria ◽  
...  
Keyword(s):  
Schiff Base ◽  
Molecular Docking ◽  
Metal Ions ◽  
Free Ligand ◽  
Schiff Base Complexes ◽  
Hydroxyl Groups ◽  
Binuclear Complexes ◽  
Central Metal ◽  
H Nmr ◽  
Biological Studies

Abstract This article aimed at the synthesis and molecular docking assessment of new diimine Schiff base ligand, namely 2-((E)-(2-((Z)-2-(4-chlorophenyl)-2-hydroxyvinyl)hydrazono) methyl)-6-methoxyphenol (methoxy-diim), via the condensation of 1-(4-chloro-phenyl)-2-hydrazino-ethenol compound with 2-((E)-(2-((Z)-2-(4-chlorophenyl)-2-hydroxy vinyl) hydrazono)methyl)-6-methoxyphenol in acetic acid as well as the preparation of new binuclear complexes of Co(ii), Ni(ii), Cu(ii), and Zn(ii). The following synthesized complexes were prepared in a ratio of 2:1 (metal/ligand). The 1H-NMR, UV-Vis, and FTIR spectroscopic data; molar conductivity measurements; and microanalytical, XRD, TGA/DTG, and biological studies were carried out to determine the molecular structure of these complexes. According to the spectroscopic analysis, the two central metal ions were coordinated with the diamine ligand via the nitrogen of the hydrazine and oxygen of the hydroxyl groups for the first metal ions and via the nitrogen of the hydrazine and oxygen of the phenol group for the second metal ions. Molecular docking for the free ligand was carried out against the breast cancer 3hb5-oxidoreductase and the 4o1v-protein binding kidney cancer and COVID-19 protease, and good results were obtained.

scholarly journals Physical properties, ligand substitution reactions, and biological activity of Co(iii)-Schiff base complexes

2019 ◽  
Vol 48 (18) ◽  
pp. 5987-6002 ◽  
Author(s):  
A. Paden King ◽  
Hendryck A. Gellineau ◽  
Samantha N. MacMillan ◽  
Justin J. Wilson
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Physical Properties ◽  
Ligand Exchange ◽  
Ligand Substitution ◽  
Schiff Base Complexes ◽  
Substitution Reactions ◽  
Anticancer Properties ◽  
Ligand Substitution Reactions

A subset of fluorinated Co(iii) Schiff base complexes was synthesized, and their structural, ligand exchange, and anticancer properties were investigated.

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