Molecular structure, molecular docking, thermal, spectroscopic and biological activity studies of bis-Schiff base ligand and its metal complexes

2017 ◽  
Vol 32 (1) ◽  
pp. e3952 ◽  
Author(s):  
Ehab M. Zayed ◽  
Ahmed M.M. Hindy ◽  
Gehad G. Mohamed
Keyword(s):  
Molecular Structure ◽  
Biological Activity ◽  
Schiff Base ◽  
Molecular Docking ◽  
Metal Complexes ◽  
Schiff Base Ligand

scholarly journals Metal Complexes of Macrocyclic Schiff-Base Ligand: Preparation, Characterisation, and Biological Activity

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Riyadh M. Ahmed ◽  
Enaam I. Yousif ◽  
Hasan A. Hasan ◽  
Mohamad J. Al-Jeboori
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Condensation Reaction ◽  
Free Ligand ◽  
Inhibition Zone ◽  
Square Planar ◽  
Planar Geometries ◽  
Macrocyclic Schiff Base

A new macrocyclic multidentate Schiff-base ligand Na4L consisting of two submacrocyclic units (10,21-bis-iminomethyl-3,6,14,17-tricyclo[17.3.1.18,12]tetracosa-1(23),2,6,8,10,12(24),13,17,19,21,-decaene-23,24-disodium) and its tetranuclear metal complexes with Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) are reported. Na4L was prepared via a template approach, which is based on the condensation reaction of sodium 2,4,6-triformyl phenolate with ethylenediamine in mole ratios of 2 : 3. The tetranuclear macrocyclic-based complexes were prepared from the reaction of the corresponding metal chloride with the ligand. The mode of bonding and overall geometry of the compounds were determined through physicochemical and spectroscopic methods. These studies revealed tetrahedral geometries about Mn, Co, and Zn atoms. However, square planar geometries have been suggested for NiIIand CuIIcomplexes. Biological activity of the ligand and its metal complexes against Gram positive bacterial strainStaphylococcus aureusand Gram negative bacteriaEscherichia colirevealed that the metal complexes become more potentially resistive to the microbial activities as compared to the free ligand. However, these metal complexes do not exhibit any effects on the activity ofPseudomonas aeruginosabacteria. There is therefore no inhibition zone.

Sign in / Sign up

Export Citation Format

Share Document