Tri- and diorganotin(IV) derivatives of non-steroidal anti-inflammatory drug sulindac: Characterization, electronic structures (DFT), DNA binding and plasmid cleavage studies

2017 ◽  
Vol 31 (8) ◽  
pp. e3661 ◽  
Author(s):  
Ranjana Kumari ◽  
Mala Nath
Keyword(s):  
Dna Binding ◽  
Electronic Structures ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Derivatives Of

Synthesis and anti-HIV Activity of New Benzimidazole, Benzothiazole and Carbohyrazide Derivatives of the anti-Inflammatory Drug Indomethacin

2011 ◽  
Vol 66 (9) ◽  
pp. 953-960 ◽  
Author(s):  
Najim A. Al-Masoudi ◽  
Nadhir N. A. Jafar ◽  
Layla J. Abbas ◽  
Sadiq J. Baqir ◽  
Christophe Pannecouque
Keyword(s):  
Phenyl Isothiocyanate ◽  
Reverse Transcriptase Inhibitors ◽  
Inflammatory Drug ◽  
Oxadiazole Derivatives ◽  
Anti Inflammatory ◽  
New Compounds ◽  
Further Development ◽  
Derivatives Of ◽  
Anti Hiv ◽  
Hiv 1

There is an urgent need for the design and development of new and safer drugs for the treatment of HIV infection, active against the currently resistant viral strains. New derivatives of the non-steroidal anti-inflammatory drug indomethacin bearing benzimidazoles, benzothiazole, purine and pyridine residues 8 - 13 were synthesized with the aim of developing new non-nucleoside reverse transcriptase inhibitors (NNRTIs).Alternatively, new imine analogs 16 - 20 were synthesized from condensation of indomethacinyl hydrazide 15, prepared from the ester 14, with various ketone precursors. Treatment of 15 with phenyl isothiocyanate or triethyl orthoformate afforded the phenylcarbonothioyl and the oxadiazole derivatives 21 and 22, respectively. The new compounds were assayed against HIV-1 and HIV-2 in MT-4 cells. Compounds 9 and 10 were the most active in inhibiting HIV-2 and HIV-1, respectively, with EC50 ≥ 17.60 μgmL−1 and > 1.15 μgmL−1 (therapeutic indexes (SI) of ≥ 3 and < 1, respectively), and are leading candidates for further development.

Synthesis and anti-HIV Activity of New Benzimidazole, Benzothiazole and Carbohyrazide Derivatives of the anti-Inflammatory Drug Indomethacin

2011 ◽  
Vol 66 ◽  
pp. 0953 ◽  
Author(s):  
N. A. Al-Masoudi ◽  
N. N. A. Jafar ◽  
L. J. Abbas ◽  
S. J. Baqir ◽  
C. Pannecouque
Keyword(s):  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Derivatives Of ◽  
Anti Hiv

1167-P: Safety and Efficacy of 52 Weeks' Therapy with Hydroxychloroquine (HCQ)—First Anti-inflammatory Drug Approved in India for T2D

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1167-P
Author(s):  
ANIL PAREEK ◽  
RAVI TEJRAJ MEHTA ◽  
SHRUTI DHARMADHIKARI ◽  
KUMAR BHASKAR NAIDU
Keyword(s):  
Safety And Efficacy ◽  
Inflammatory Drug ◽  
Anti Inflammatory
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